Clinicopathological and molecular characteristics of synchronous gastric adenocarcinoma and gastrointestinal stromal tumors
| العنوان: | Clinicopathological and molecular characteristics of synchronous gastric adenocarcinoma and gastrointestinal stromal tumors |
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| المؤلفون: | Fa-Long Cao, Siqing Ma, Chen Meng, Yichun Wang, Jian-Guo Xin, Shao-Hua Peng, Guirong Wang, Hong-Ling Gao, Sara Javidiparsijani, Shukun Zhang, Li-Jun Lin, Meng-Lan Zhang, Junming Luo |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
| بيانات النشر: | Nature Publishing Group UK, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Mutation rate, Gastrointestinal Stromal Tumors, CD34, lcsh:Medicine, Adenocarcinoma, Article, Neoplasms, Multiple Primary, 03 medical and health sciences, Exon, 0302 clinical medicine, Stomach Neoplasms, medicine, Humans, Stromal tumor, lcsh:Science, neoplasms, Aged, Multidisciplinary, biology, GiST, Base Sequence, CD117, lcsh:R, DNA, Neoplasm, Oncogenes, Middle Aged, medicine.disease, digestive system diseases, 3. Good health, 030220 oncology & carcinogenesis, Mutation, biology.protein, Cancer research, Immunohistochemistry, 030211 gastroenterology & hepatology, lcsh:Q, Female |
| الوصف: | Synchronous gastric tumors that consist of both gastrointestinal stromal tumor (GIST) and adenocarcinoma are rare. We studied the clinicopathological and molecular characteristics of six cases containing both gastric adenocarcinoma and GIST. By means of immunohistochemical analysis, all GIST cells expressed CD117, CD34 and Dog1 in all six synchronous gastric adenocarcinomas with GIST, and in GIST alone. Sequencing analysis demonstrated that exon 11 c-kit mutations were present in two of six synchronous tumors and four of five GISTs. One of the two exon 11 c-kit mutations in synchronous adenocarcinomas with GISTs was an uncommon mutation of CTT > CCA at amino acid 576, and the other was a GTT deletion at amino acid 560. The mutation was a homozygous A > G mutation in exon 12 (amino acid 567) of PDGFR-α. We concluded that the exon 11 mutations were the most important in both cases of synchronous gastric adenocarcinoma with GIST and GIST alone. The mutation rate was higher in GIST alone than in synchronous adenocarcinoma with GIST. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0823934269aaea36f47eed5aa25f90c4Test http://europepmc.org/articles/PMC5635104Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0823934269aaea36f47eed5aa25f90c4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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