Impact of erroneous meal insulin bolus with dual-hormone artificial pancreas using a simplified bolus strategy - A randomized controlled trial
| العنوان: | Impact of erroneous meal insulin bolus with dual-hormone artificial pancreas using a simplified bolus strategy - A randomized controlled trial |
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| المؤلفون: | Charlotte Cameli, Laurent Legault, Véronique Gingras, Virginie Messier, Martin Ladouceur, Rémi Rabasa-Lhoret, Mohamed Raef Smaoui |
| المصدر: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) |
| بيانات النشر: | Nature Publishing Group UK, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, Pancreas, Artificial, medicine.medical_treatment, lcsh:Medicine, 030209 endocrinology & metabolism, Hypoglycemia, Artificial pancreas, Glucagon, Article, 03 medical and health sciences, 0302 clinical medicine, Bolus (medicine), Insulin Infusion Systems, medicine, Humans, Hypoglycemic Agents, Insulin, 030212 general & internal medicine, lcsh:Science, Type 1 diabetes, Meal, Multidisciplinary, business.industry, lcsh:R, digestive, oral, and skin physiology, Middle Aged, medicine.disease, Postprandial Period, Postprandial, Diabetes Mellitus, Type 1, Anesthesia, lcsh:Q, Female, business |
| الوصف: | Postprandial glucose control remains challenging for patients with type 1 diabetes (T1D). A simplified meal bolus approach with a dual-hormone (insulin and glucagon) closed-loop system (DH-CLS) has been tested; yet, the impact of categorization errors with this strategy is unknown. The objective was to compare, in a randomized controlled inpatient trial, DH-CLS with the simplified meal bolus approach for two different meals properly categorized or overestimated. We tested, in patients with T1D, the simplified strategy with two standardized breakfasts (n = 10 per meal) adequately categorized or overestimated: (1) 75 g and (2) 45 g of carbohydrate. No difference was observed for percentage of time in silico with comparable results. These results suggest that the DH-CLS with a simplified meal bolus calculation is probably able to avoid hypoglycemia in the event of meal size misclassification. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db4380867818802312c7cf9e9b2bd27bTest http://europepmc.org/articles/PMC5805693Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db4380867818802312c7cf9e9b2bd27b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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