Association between Lower Extremity Skeletal Muscle Mass and Impaired Cognitive Function in Type 2 Diabetes
| العنوان: | Association between Lower Extremity Skeletal Muscle Mass and Impaired Cognitive Function in Type 2 Diabetes |
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| المؤلفون: | Tavintharan Subramaniam, Jiexun Wang, Angela Moh, Pek Yee Kwan, Su Chi Lim, Chin Leong Lim, Tze Pin Ng, Keven Ang, Serena Low, Su Fen Ang, Kiat Sern Goh, Chee Fang Sum, Wern Ee Tang |
| المساهمون: | Lee Kong Chian School of Medicine (LKCMedicine) |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Repeatable Battery for the Assessment of Neuropsychological Status, Sarcopenia, lcsh:Medicine, Type 2 diabetes, Neuropsychological Tests, Article, 03 medical and health sciences, 0302 clinical medicine, Cognition, Internal medicine, medicine, Electric Impedance, Humans, Medicine [Science], Cognitive Dysfunction, 030212 general & internal medicine, Effects of sleep deprivation on cognitive performance, Association (psychology), lcsh:Science, Muscle, Skeletal, Aged, Singapore, Multidisciplinary, business.industry, lcsh:R, Skeletal muscle, Middle Aged, Skeletal muscle mass, medicine.disease, Type 2 Diabetes, medicine.anatomical_structure, Cross-Sectional Studies, Neurology, Diabetes Mellitus, Type 2, Lower Extremity, Cardiology, Body Composition, lcsh:Q, Female, business, Bioelectrical impedance analysis, 030217 neurology & neurosurgery |
| الوصف: | Lower extremity skeletal muscle mass (LESM) in Type 2 Diabetes (T2D) has been linked to adverse clinical events, but it is not known whether it is associated with cognitive difficulties. We conducted a cross-sectional study on 1,235 people (mean age 61.4 ± 8.0 years) with T2D under primary and secondary care in Singapore. Bioelectrical impedance analyses (BIA) measures of upper extremity skeletal muscle mass (UESM), LESM and appendicular skeletal muscle index (SMI) were related to the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) measures of cognition, in multiple linear regression. In multivariable models, tertile 1 LESM (b = −2.62 (−3.92 to −1.32)) and tertile 2 LESM (b = −1.73 (−2.73 to −0.73)), referenced to tertile 3) were significantly associated with decreased RBANS total score. Significant associations of LESM with cognitive domain performances were observed for tertile 1 (b = −3.75 (−5.98 to −1.52)) and tertile 2 (b = −1.98 (−3.69 to −0.27)) with immediate memory, and for tertile 1 (b = −3.05 (−4.86 to −1.24)) and tertile 2 (b = −1.87 (−3.25 to −0.48)) with delayed memory, and for tertile 1 (b = −2.99 (−5.30 to −0.68)) with visuospatial/constructional ability. Tertile 1 SMI (b = −1.94 (−3.79 to −0.08) and tertile 2 SMI (b = −1.75 (−3.14 to −0.37)) were also associated with delayed memory. There were no associations between UESM with cognitive performance. Lower LESM may be a useful marker of possible co-occuring cognitive dysfunction. Ministry of Health (MOH) National Medical Research Council (NMRC) Published version This study was supported by the Singapore Ministry of Health’s National Medical Research Council under CS-IRG (MOH-000066) and NMRC/CIRG/1398/2014. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dce1f2a4751d91e5e6dd69d93755e4dTest http://europepmc.org/articles/PMC7031513Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0dce1f2a4751d91e5e6dd69d93755e4d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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