Lactobacillus reuteri HCM2 protects mice against Enterotoxigenic Escherichia coli through modulation of gut microbiota
| العنوان: | Lactobacillus reuteri HCM2 protects mice against Enterotoxigenic Escherichia coli through modulation of gut microbiota |
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| المؤلفون: | Yayong Liu, Xin Zhang, Kunling Teng, Min Zhang, Gang Liu, Jin Zhong, Jie Zhang, Yong Tao, Tianwei Wang |
| المصدر: | Scientific Reports Scientific Reports, Vol 8, Iss 1, Pp 1-14 (2018) |
| بيانات النشر: | Nature Publishing Group UK, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, Limosilactobacillus reuteri, lcsh:Medicine, Gut flora, medicine.disease_cause, digestive system, Bacterial Adhesion, Article, Microbiology, Jejunum, 03 medical and health sciences, Mice, fluids and secretions, Bacterial Proteins, Enterotoxigenic Escherichia coli, medicine, Animals, Intestinal Mucosa, lcsh:Science, Gastrointestinal tract, Multidisciplinary, biology, lcsh:R, food and beverages, medicine.disease, biology.organism_classification, bacterial infections and mycoses, Lactobacillus reuteri, Gastrointestinal Microbiome, Diarrhea, 030104 developmental biology, medicine.anatomical_structure, lcsh:Q, medicine.symptom, Dysbiosis, Bacteria |
| الوصف: | Enterotoxigenic Escherichia coli (ETEC) is a leading cause of infectious diarrhea in children and postweaning piglets. ETEC infection results in induced pro-inflammatory responses in intestinal epithelial cells and dysbiosis of intestinal microbiota. Here, a Lactobacillus reuteri strain, HCM2, isolated from a healthy piglet showed a high survival rate in the harsh gastrointestinal tract environment and inhibited the growth of ETEC and its adherence to intestinal epithelial cells. Pre-supplementation with L. reuteri HCM2 for 14 days reduced the ETEC load in the jejunum of ETEC-infected mice and prevented the disruption of intestinal morphology by ETEC. The colonic microbiota of mice with or without HCM2 pre-supplementation were analyzed, and this analysis revealed that HCM2 could prevent dysbiosis caused by ETEC infection by stabilizing the relative abundance of dominant bacteria. These results indicate that L. reuteri HCM2 has the potential to attenuate the effect of ETEC on the colonic microbiota in infected mice. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6728b35ceaa0a7cc847b347c2db18745Test http://europepmc.org/articles/PMC6269427Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6728b35ceaa0a7cc847b347c2db18745 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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