Neopterin and biopterin levels and tryptophan degradation in patients with diabetes
| العنوان: | Neopterin and biopterin levels and tryptophan degradation in patients with diabetes |
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| المؤلفون: | Terken Baydar, Gözde Girgin, Bilge Kilicarslan, Belgin Efe, Goknur Yorulmaz, Sinem Gurcu |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020) |
| بيانات النشر: | Nature Publishing Group UK, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, endocrine system diseases, Physiology, lcsh:Medicine, Type 2 diabetes, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, immune system diseases, Medicine, Insulin, Vildagliptin, lcsh:Science, Kynurenine, Aged, 80 and over, Multidisciplinary, Biological techniques, Tryptophan, Neopterin, Middle Aged, Metformin, 030220 oncology & carcinogenesis, Female, medicine.drug, Adult, medicine.medical_specialty, Adolescent, Urinary system, Immunology, Biopterin, Article, 03 medical and health sciences, Young Adult, Internal medicine, Diabetes mellitus, Humans, Hypoglycemic Agents, Aged, business.industry, lcsh:R, nutritional and metabolic diseases, medicine.disease, 030104 developmental biology, Diabetes Mellitus, Type 1, chemistry, Diabetes Mellitus, Type 2, lcsh:Q, business, Health occupations |
| الوصف: | This study aimed to evaluate the possible changes of neopterin, biopterin levels and tryptophan degradation in diabetes and to compare the results within diabetes groups and with healthy subjects. Diabetes mellitus patients and healthy controls were recruited the study. Patients were further subgrouped according to their drug therapy. Serum neopterin concentrations were detected by ELISA. Urinary neopterin, biopterin, serum tryptophan (Trp) and kynurenine (Kyn) levels were detected by HPLC. There was no difference between controls and diabetes patients in serum neopterin, urinary neopterin and biopterin levels (p > 0.05, all). Serum Trp and Kyn levels were significantly different in type 1 diabetes (T1DM) patients compared to controls (p |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d014715d03bbfdb20a5231e8383a0fTest http://europepmc.org/articles/PMC7552423Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....15d014715d03bbfdb20a5231e8383a0f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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