The influence of the mating type on virulence of Mucor irregularis
| العنوان: | The influence of the mating type on virulence of Mucor irregularis |
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| المؤلفون: | Zhimin Long, Clement K. M. Tsui, Dongmei Li, Huan Mei, Guixia Lv, Yongnian Shen, Meihua Fu, Wenqi Xu, Qiong Wang, Jingwen Peng, Guanzhao Liang, Weida Liu |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Mucorales, Mating type, 030106 microbiology, Virulence, lcsh:Medicine, Locus (genetics), Biology, Article, Immunophenotyping, Pathogenesis, 03 medical and health sciences, Mice, T-Lymphocyte Subsets, Gene Order, Animals, Mucormycosis, Heterothallic, Allele, Promoter Regions, Genetic, lcsh:Science, Gene, reproductive and urinary physiology, Genetics, Multidisciplinary, lcsh:R, Dermis, Sequence Analysis, DNA, biology.organism_classification, Genes, Mating Type, Fungal, Mucor, behavior and behavior mechanisms, Cytokines, lcsh:Q, Biomarkers |
| الوصف: | Mucor irregularis is an emerging fungal pathogen that cause cutaneous infection and could cause death. However, little is known about its mechanism of pathogenesis. There is evidence suggesting virulence vary with mating types in fungi, including the Mucorales. Here, we characterized the mating type locus of M. irregularis and the mating type ratio of 17 clinical isolates in China. Genomic data indicated M. irregularis is heterothallic having two mating types – bearing either SexP or SexM allele. Also, we employed a mice model to study the inflammation and pathological effects of different mating types. The comparison of the inflammatory response, cytokine profiles and Th-1, Th-2 and Th-17 cells numbers in each mating type treated mice showed that the severity and disease progress were enhanced in (+) mating type treated mice. One (+/0) mutant strain, with multiple mutations at the mating locus, had defects in sexual mating ability but appeared to be more virulent than the (−) mating type. Although (+) mating type appeared to be more virulent, most of our clinical isolates presented belonged to (−) mating type. Our findings support the involvement of MAT genes in sexual fertility, and the influence of mating type on the severity of cutaneous infection. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16ed1a6ba6dd0850e21b0c5b880d7c74Test http://link.springer.com/article/10.1038/s41598-017-10954-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....16ed1a6ba6dd0850e21b0c5b880d7c74 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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