دورية أكاديمية
Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy
| العنوان: | Inhibiting bacterial cooperation is an evolutionarily robust anti-biofilm strategy |
|---|---|
| المؤلفون: | Dieltjens L., Appermans K., Lissens M., Lories B., Kim W., Foster K.R., Steenackers H.P., Van Der Eycken E.V. |
| المصدر: | Nature Communications |
| بيانات النشر: | Nature Publishing Group |
| المجموعة: | RUDN University Open Repository (RUOR) |
| مصطلحات موضوعية: | 2 cyclopentenyl 5 (4 chlorophenyl) 2 aminoimidazole, bacterial protein, ciprofloxacin, crystal violet, curlin, hydrogen peroxide, imidazole derivative, spectinomycin, unclassified drug, antimicrobial activity, bacterium, biofilm, cell, experimental study, inhibition, inhibitor, polymer, antibiofilm activity, antibiotic resistance, antibiotic sensitivity, Article, bacterial colonization, bacterial growth, bacterium adherence, bacterium culture, biofilm matrix, biomass, biomass production, cell adhesion, colony formation |
| الوصف: | Bacteria commonly form dense biofilms encased in extracellular polymeric substances (EPS). Biofilms are often extremely tolerant to antimicrobials but their reliance on shared EPS may also be a weakness as social evolution theory predicts that inhibiting shared traits can select against resistance. Here we show that EPS of Salmonella biofilms is a cooperative trait whose benefit is shared among cells, and that EPS inhibition reduces both cell attachment and antimicrobial tolerance. We then compare an EPS inhibitor to conventional antimicrobials in an evolutionary experiment. While resistance against conventional antimicrobials rapidly evolves, we see no evolution of resistance to EPS inhibition. We further show that a resistant strain is outcompeted by a susceptible strain under EPS inhibitor treatment, explaining why resistance does not evolve. Our work suggests that targeting cooperative traits is a viable solution to the problem of antimicrobial resistance. © 2020, The Author(s). |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1038/s41467-019-13660-xTest; https://repository.rudn.ru/records/article/record/56489Test/ |
| الإتاحة: | https://doi.org/10.1038/s41467-019-13660-xTest https://repository.rudn.ru/records/article/record/56489Test/ |
| رقم الانضمام: | edsbas.DACEFC0A |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |