Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to high altitude
| العنوان: | Enhanced flow-motion complexity of skin microvascular perfusion in Sherpas and lowlanders during ascent to high altitude |
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| المؤلفون: | Geraldine F. Clough, Edward Gilbert-Kawai, Deborah Carey, Michael P.W. Grocott, Denny Z. H. Levett, Daniel Martin, Thomas W. Davies, Andrew J. Chipperfield, Michael G. Mythen, Marjola Thanaj, Kay Mitchell |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Acclimatization, lcsh:Medicine, 030204 cardiovascular system & hematology, Hypoxic exposure, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Hypoxia, lcsh:Science, Skin, Multidisciplinary, Chemistry, Altitude, Microcirculation, lcsh:R, Blood flow, Effects of high altitude on humans, Oxygen, Microvascular perfusion, Base camp, Tissue oxygenation, Microvascular Network, Cardiology, Female, Hypobaric hypoxia, lcsh:Q, Biomedical engineering, Perfusion, 030217 neurology & neurosurgery |
| الوصف: | An increased and more effective microvascular perfusion is postulated to play a key role in the physiological adaptation of Sherpa highlanders to the hypobaric hypoxia encountered at high altitude. To investigate this, we used Lempel-Ziv complexity (LZC) analysis to explore the spatiotemporal dynamics of the variability of the skin microvascular blood flux (BF) signals measured at the forearm and finger, in 32 lowlanders (LL) and 46 Sherpa highlanders (SH) during the Xtreme Everest 2 expedition. Measurements were made at baseline (BL) (LL: London 35 m; SH: Kathmandu 1300 m) and at Everest base camp (LL and SH: EBC 5,300 m). We found that BF signal content increased with ascent to EBC in both SH and LL. At both altitudes, LZC of the BF signals was significantly higher in SH, and was related to local slow-wave flow-motion activity over multiple spatial and temporal scales. In SH, BF LZC was also positively associated with LZC of the simultaneously measured tissue oxygenation signals. These data provide robust mechanistic information of microvascular network functionality and flexibility during hypoxic exposure on ascent to high altitude. They demonstrate the importance of a sustained heterogeneity of network perfusion, associated with local vaso-control mechanisms, to effective tissue oxygenation during hypobaric hypoxia. |
| وصف الملف: | text |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d74552643761fb2b883866edd87669fTest http://link.springer.com/article/10.1038/s41598-019-50774-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0d74552643761fb2b883866edd87669f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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