المؤلفون: Kim, Daehong, Park, Giljun, Huuhtanen, Jani, Lundgren, Sofie, Khajuria, Rajiv K., Hurtado, Ana M., Muñoz-Calleja, Cecilia, Cardeñoso, Laura, Gómez-García de Soria, Valle, Chen-Liang, Tzu Hua, Eldfors, Samuli, Ellonen, Pekka, Hannula, Sari, Kankainen, Matti, Bruck, Oscar, Kreutzman, Anna, Salmenniemi, Urpu, Lönnberg, Tapio, Jerez, Andrés, Itälä-Remes, Maija, Myllymäki, Mikko, Keränen, Mikko A.I., Mustjoki, Satu

المساهمون: UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

مصطلحات موضوعية: Hematopoietic stem cell transplantation (HSCT), Mutations, Alteration and activation, Apoptosis, Resistance to mTOR inhibitors, Medicina

وصف الملف: application/pdf

العلاقة: Nature Communications; https://doi.org/10.1038/s41467-020-16115-wTest; Nature Communications 11.1 (2020): 2246; http://hdl.handle.net/10486/695180Test; 2246-1; 2246-17; 11

الإتاحة: https://doi.org/10.1038/s41467-020-16115-wTest
http://hdl.handle.net/10486/695180Test

المؤلفون: Geuna, E, Roda, D, Rafii, S, Jimenez, B, Capelan, M, Rihawi, K, Montemurro, F, Yap, T A, Kaye, S B, De Bono, J S, Molife, L R, Banerji, U

المصدر: British Journal of Cancer

مصطلحات موضوعية: Adult, Blood Glucose, Male, mTOR inhibitors, Adolescent, Antineoplastic Agents, Severity of Illness Index, Young Adult, Risk Factors, Neoplasms, Hyperglycaemia, Humans, Hypoglycemic Agents, Protein Kinase Inhibitors, Aged, Phosphoinositide-3 Kinase Inhibitors, Retrospective Studies, Aged, 80 and over, Clinical Trials, Phase I as Topic, metabolic complications, TOR Serine-Threonine Kinases, AKT inhibitors, PI3K inhibitors, Middle Aged, Case-Control Studies, Hyperglycemia, Clinical Study, PI3K–AKT–mTOR pathway, Female, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::fae21ccd41a8d0c04c35fbb9721a2e35Test
http://europepmc.org/articles/PMC4705886Test

المؤلفون: Jonathan D. Cheng, Lainie P. Martin, J. Fiorica, Raanan Berger, Paul Haluska, William S. Dalton, M. B. Jones, Shannon N. Westin, Lillian L. Siu, Talia Golan, J. Stephenson, Jhanelle E. Gray, Khaldoun Almhanna, R. M. Wenham, P. Hanjani, Alexandra Gunchenko, Daniel M. Sullivan, J. Edenfield, Irene Brana

المصدر: British Journal of Cancer

مصطلحات موضوعية: Male, Cancer Research, Akt inhibitor, Pharmacology, Receptor, IGF Type 1, Cohort Studies, chemistry.chemical_compound, MK-0752, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Benzene Derivatives, Medicine, Tissue Distribution, Sulfones, Randomized Controlled Trials as Topic, Aged, 80 and over, biology, Receptors, Notch, TOR Serine-Threonine Kinases, Antibodies, Monoclonal, Middle Aged, Discovery and development of mTOR inhibitors, Prognosis, ovarian cancer, Oncology, MK-2206, Female, Antibody, Heterocyclic Compounds, 3-Ring, Adult, colorectal cancer, Antibodies, Monoclonal, Humanized, Ridaforolimus, Clinical Trials, Phase II as Topic, ridaforolimus, Biomarkers, Tumor, Humans, In patient, Aged, Neoplasm Staging, dalotuzumab, Sirolimus, business.industry, Dalotuzumab, chemistry, Clinical Trials, Phase III as Topic, biology.protein, Clinical Study, Propionates, business, Proto-Oncogene Proteins c-akt, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f49b7b9125e9a40ceec15ef2e49d7c9Test
http://europepmc.org/articles/PMC4229637Test

المؤلفون: Mohamad A. Zaini, Jeanette Reinshagen, Tobias Ackermann, Cornelis F. Calkhoven, Ole Pless, Gertrud Kortman, Christine Müller

المساهمون: Publica

المصدر: Scientific Reports
Scientific Reports, 7:42603. Nature Publishing Group

مصطلحات موضوعية: 0301 basic medicine, EXPRESSION, Calorie restriction, Genetic Vectors, PROTEIN, Gene Expression, RE-INITIATION, mTORC1, Biology, Article, Cell Line, CONTROL REPORTER SYSTEM, 03 medical and health sciences, Genes, Reporter, Enhancer binding, Upstream open reading frame, Drug Discovery, Gene Order, Protein biosynthesis, Humans, RNA, Messenger, Transcription factor, IMPROVES METABOLIC HEALTH, Caloric Restriction, Regulation of gene expression, Multidisciplinary, MTOR INHIBITORS, CCAAT-Enhancer-Binding Protein-beta, Reproducibility of Results, Translation (biology), CANCER, Cell biology, High-Throughput Screening Assays, MICE, stomatognathic diseases, 030104 developmental biology, Biochemistry, Gene Expression Regulation, MAMMALIAN LIFE-SPAN, Protein Biosynthesis, MESSENGER-RNA

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05625b2186ea195c2e46c4118f18ee97Test
http://europepmc.org/articles/PMC5309760Test

المؤلفون: Razelle Kurzrock, Udai Banerji, Carol Aghajanian, David Olmos, Stan B. Kaye, Elisabeth Oelmann, Aung Naing, William L Burke, Robert H Taylor, Gary G Schwartz, Lynda Grinsted, Eric Raymond

المصدر: British Journal of Cancer

مصطلحات موضوعية: Drug, Adult, Male, Cancer Research, medicine.medical_specialty, mTOR inhibitors, Lymphoma, Maximum Tolerated Dose, media_common.quotation_subject, Morpholines, Mechanistic Target of Rapamycin Complex 2, Pharmacology, Mechanistic Target of Rapamycin Complex 1, Gastroenterology, Drug Administration Schedule, Cohort Studies, Stable Disease, Pharmacokinetics, Internal medicine, Neoplasms, Medicine, Humans, Dosing, Adverse effect, media_common, Aged, Dose-Response Relationship, Drug, business.industry, TOR Serine-Threonine Kinases, AZD8055, phase I, Middle Aged, medicine.disease, Oncology, Tolerability, Multiprotein Complexes, Elevated transaminases, Female, business, Translational Therapeutics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a485a49be57a5c43fcb8ae4edd16f1Test
http://europepmc.org/articles/PMC3461162Test

المؤلفون: Kaymakcalan, M D, Je, Y, Sonpavde, G, Galsky, M, Nguyen, P L, Heng, D Y C, Richards, C J, Choueiri, T K

مصطلحات موضوعية: renal cell carcinoma, mTOR inhibitors, temsirolimus, everolimus, infections, meta-analysis

وصف الملف: application/pdf

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3694254/pdfTest/; British Journal of Cancer; Kaymakcalan, M D, Y Je, G Sonpavde, M Galsky, P L Nguyen, D Y C Heng, C J Richards, and T K Choueiri. 2013. “Risk of infections in renal cell carcinoma (RCC) and non-RCC patients treated with mammalian target of rapamycin inhibitors.” British Journal of Cancer 108 (12): 2478-2484. doi:10.1038/bjc.2013.278. http://dx.doi.org/10.1038/bjc.2013.278Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406778Test

الإتاحة: https://doi.org/10.1038/bjc.2013.278Test
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12406778Test