المؤلفون: Smith, D., Eade, R., Andrews, M., Ayres, H., Clark, A., Chripko, S., Deser, C., Dunstone, N., García-Serrano, Javier, Gastineau, Guillaume, Graff, L., Hardiman, S., He, B., Hermanson, L., Jung, T., Knight, J., Levine, Xavier, Magnusdottir, G., Manzini, Elisa, Matei, Daniela, Mori, M., Msadek, Rym, Ortega, Pablo, Peings, Y., Scaife, A., Screen, J., Seabrook, M., Semmler, T., Sigmond, M., Streffing, J., Sun, L., Walsh, A.

المساهمون: Met Office Hadley Centre (MOHC), United Kingdom Met Office Exeter, Department of Meteorology Reading, University of Reading (UOR), Centre Européen de Recherche et de Formation Avancée en Calcul Scientifique (CERFACS), National Center for Atmospheric Research Boulder (NCAR), Universitat de Barcelona (UB), Océan et variabilité du climat (VARCLIM), Laboratoire d'Océanographie et du Climat : Expérimentations et Approches Numériques (LOCEAN), Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-École polytechnique (X)-Centre National d'Études Spatiales Toulouse (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-École normale supérieure - Paris (ENS-PSL), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales Toulouse (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Muséum national d'Histoire naturelle (MNHN)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut Pierre-Simon-Laplace (IPSL (FR_636)), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Centre National d'Études Spatiales Toulouse (CNES)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Norwegian Meteorological Institute Oslo (MET), Institute of Atmospheric Physics Beijing (IAP), Chinese Academy of Sciences Beijing (CAS), Alfred Wegener Institute Potsdam, Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung = Alfred Wegener Institute for Polar and Marine Research = Institut Alfred-Wegener pour la recherche polaire et marine (AWI), Helmholtz-Gemeinschaft = Helmholtz Association-Helmholtz-Gemeinschaft = Helmholtz Association, Barcelona Supercomputing Center - Centro Nacional de Supercomputacion (BSC-CNS), Department of Earth System Science Irvine (ESS), University of California Irvine (UC Irvine), University of California (UC)-University of California (UC), Max-Planck-Institut für Meteorologie (MPI-M), Max-Planck-Gesellschaft, Research Institute for Applied Mechanics Fukuoka (RIAM), Kyushu University, College of Engineering, Mathematics and Physical Sciences Exeter (EMPS), University of Exeter, Canadian Centre for Climate Modelling and Analysis (CCCma), Environment and Climate Change Canada (ECCC), Department of Atmospheric Science Fort Collins, Colorado State University Fort Collins (CSU), European Project: 727852,Blue-Action(2016), European Project: 727862,APPLICATE

المصدر: ISSN: 2041-1723.

مصطلحات موضوعية: [PHYS.PHYS.PHYS-GEO-PH]Physics [physics]/Physics [physics]/Geophysics [physics.geo-ph]

الوصف: International audience ; The possibility that Arctic sea ice loss weakens mid-latitude westerlies, promoting more severe cold winters, has sparked more than a decade of scientific debate, with apparent support from observations but inconclusive modelling evidence. Here we show that sixteen models contributing to the Polar Amplification Model Intercomparison Project simulate a weakening of mid-latitude westerlies in response to projected Arctic sea ice loss. We develop an emergent constraint based on eddy feedback, which is 1.2 to 3 times too weak in the models, suggesting that the real-world weakening lies towards the higher end of the model simulations. Still, the modelled response to Arctic sea ice loss is weak: the North Atlantic Oscillation response is similar in magnitude and offsets the projected response to increased greenhouse gases, but would only account for around 10% of variations in individual years. We further find that relationships between Arctic sea ice and atmospheric circulation have weakened recently in observations and are no longer inconsistent with those in models.

العلاقة: info:eu-repo/grantAgreement//727852/EU/Blue-Action: Arctic impact on weather and climat/Blue-Action; info:eu-repo/grantAgreement//727862/EU/Advanced Prediction in Polar regions and beyond: Modelling, observing system design and LInkages associated with ArctiC ClimATE change/APPLICATE; hal-03608281; https://hal.science/hal-03608281Test; https://hal.science/hal-03608281/documentTest; https://hal.science/hal-03608281/file/s41467-022-28283-y.pdfTest; PUBMEDCENTRAL: PMC8821642; WOS: 000752524300009

الإتاحة: https://doi.org/10.1038/s41467-022-28283-yTest
https://hal.science/hal-03608281Test
https://hal.science/hal-03608281/documentTest
https://hal.science/hal-03608281/file/s41467-022-28283-y.pdfTest

المؤلفون: Smith, D. M., Eade, R., Andrews, M. B., Ayres, Holly, Clark, A., Chripko, S., Deser, C., Dunstone, N. J., García-Serrano, J., Gastineau, G., Graff, L. S., Hardiman, S. C., He, B., Hermanson, L., Jung, T., Knight, T., Levine, X., Magnusdottir, G., Manzini, E., Matei, D., Mori, M., Msadek, R., Ortega, P., Peings, Y., Scaife, A. A., Seabrook, M., Semmler, T., Sigmond, M., Streffing, J., Sun, L., Walsh, A.

الوصف: The possibility that Arctic sea ice loss weakens mid-latitude westerlies, promoting more severe cold winters, has sparked more than a decade of scientific debate, with apparent support from observations but inconclusive modelling evidence. Here we show that sixteen models contributing to the Polar Amplification Model Intercomparison Project simulate a weakening of mid-latitude westerlies in response to projected Arctic sea ice loss. We develop an emergent constraint based on eddy feedback, which is 1.2 to 3 times too weak in the models, suggesting that the real-world weakening lies towards the higher end of the model simulations. Still, the modelled response to Arctic sea ice loss is weak: the North Atlantic Oscillation response is similar in magnitude and offsets the projected response to increased greenhouse gases, but would only account for around 10% of variations in individual years. We further find that relationships between Arctic sea ice and atmospheric circulation have weakened recently in observations and are no longer inconsistent with those in models.

وصف الملف: text

العلاقة: https://centaur.reading.ac.uk/103018/1/s41467-022-28283-y.pdfTest; Smith, D. M., Eade, R., Andrews, M. B., Ayres, H. orcid:0000-0003-0294-7620 , Clark, A., Chripko, S., Deser, C., Dunstone, N. J., García-Serrano, J., Gastineau, G., Graff, L. S., Hardiman, S. C., He, B., Hermanson, L., Jung, T., Knight, T., Levine, X., Magnusdottir, G., Manzini, E., Matei, D., Mori, M., Msadek, R., Ortega, P., Peings, Y., Scaife, A. A., Seabrook, M., Semmler, T., Sigmond, M., Streffing, J., Sun, L. and Walsh, A. (2022) Robust but weak winter atmospheric circulation response to future Arctic sea ice loss. Nature Communications, 13 (1). 727. ISSN 2041-1723 doi: https://doi.org/10.1038/s41467-022-28283-yTest

الإتاحة: https://doi.org/10.1038/s41467-022-28283-yTest
https://centaur.reading.ac.uk/103018Test/
https://centaur.reading.ac.uk/103018/1/s41467-022-28283-y.pdfTest
https://www.nature.com/articles/s41467-022-28283-yTest

المؤلفون: Cohen, J, Zhang, X, Francis, J, Jung, T, Kwok, R, Overland, J, Ballinger, TJ, Bhatt, US, Chen, HW, Coumou, D, Feldstein, S, Gu, H, Handorf, D, Henderson, G, Ionita, M, Kretschmer, M, Laliberte, F, Lee, S, Linderholm, HW, Maslowski, W, Peings, Y, Pfeiffer, K, Rigor, I, Semmler, T, Stroeve, J, Taylor, PC, Vavrus, S, Vihma, T, Wang, S, Wendisch, M, Wu, Y, Yoon, J

المصدر: Nature Climate Change , 10 (1) pp. 20-29. (2020)

مصطلحات موضوعية: Atmospheric science, Climate change, Cryospheric science

الوصف: The Arctic has warmed more than twice as fast as the global average since the late twentieth century, a phenomenon known as Arctic amplification (AA). Recently, there have been considerable advances in understanding the physical contributions to AA, and progress has been made in understanding the mechanisms that link it to midlatitude weather variability. Observational studies overwhelmingly support that AA is contributing to winter continental cooling. Although some model experiments support the observational evidence, most modelling results show little connection between AA and severe midlatitude weather or suggest the export of excess heating from the Arctic to lower latitudes. Divergent conclusions between model and observational studies, and even intramodel studies, continue to obfuscate a clear understanding of how AA is influencing midlatitude weather.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10094804/1/Cohen_Review_revised2.7_clean.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10094804Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10094804/1/Cohen_Review_revised2.7_clean.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10094804Test/

المؤلفون: Cohen, J., Zhang, X., Francis, J., Jung, T., Kwok, R., Overland, J., Ballinger, T. J., Bhatt, U. S., Chen, H. W., Coumou, D., Feldstein, S., Gu, H., Handorf, D., Henderson, G., Ionita, M., Kretschmer, M., Laliberte, F., Lee, S., Linderholm, H. W., Maslowski, W., Peings, Y., Pfeiffer, K., Rigor, I., Semmler, T., Stroeve, J., Taylor, P. C., Vavrus, S., Vihma, T., Wang, S., Wendisch, M., Wu, Y., Yoon, J.

المصدر: Nature Climate Change; 10, pp 20-29 (2020) ; ISSN: 1758-678X

مصطلحات موضوعية: Climate Research, Meteorology and Atmospheric Sciences

الوصف: The Arctic has warmed more than twice as fast as the global average since the late twentieth century, a phenomenon known as Arctic amplification (AA). Recently, there have been considerable advances in understanding the physical contributions to AA, and progress has been made in understanding the mechanisms that link it to midlatitude weather variability. Observational studies overwhelmingly support that AA is contributing to winter continental cooling. Although some model experiments support the observational evidence, most modelling results show little connection between AA and severe midlatitude weather or suggest the export of excess heating from the Arctic to lower latitudes. Divergent conclusions between model and observational studies, and even intramodel studies, continue to obfuscate a clear understanding of how AA is influencing midlatitude weather.

العلاقة: https://lup.lub.lu.se/record/16b82b99-0f95-451e-b5e4-10d307d8b121Test; http://dx.doi.org/10.1038/s41558-019-0662-yTest; scopus:85077169689

الإتاحة: https://doi.org/10.1038/s41558-019-0662-yTest
https://lup.lub.lu.se/record/16b82b99-0f95-451e-b5e4-10d307d8b121Test

المؤلفون: Shim, H B, Kim, Y D, Jung, T Y, Lee, J K, Ku, J H

مصطلحات موضوعية: Age Factors, Aged, 80 and over, Asian Continental Ancestry Group, Autonomic Nervous System/physiopathology, Biological Markers/blood, Case-Control Studies, Comorbidity, Cross-Sectional Studies, Gonadotropins/blood, Humans, Korea/epidemiology, Male, Middle Aged, Organ Size, Prospective Studies, Prostate/innervation/secretion/*ultrasonography, Prostate-Specific Antigen/*blood/secretion, Spinal Cord Injuries/*blood/*epidemiology/physiopathology, Statistics as Topic, Testosterone/blood/secretion

الوصف: STUDY DESIGN: Prospective, cross-sectional, case-control study. SETTING: Outpatient department in Seoul, Korea. OBJECTIVES: To assess prostate volume and serum prostate-specific antigen (PSA) levels in Korean men with spinal cord injury (SCI). METHODS: A total of 31 SCI patients with ages ranging between 45 and 81 years old (median age, 58 years) were studied. Thirty-one age-matched individuals without SCI were enrolled in the study as controls. We tested PSA levels and performed transrectal ultrasonographies on all enrolled patients. Of the patients with SCI, 20 were evaluated for testosterone, luteinizing hormone (LH), and follicle-stimulating hormone (FSH) levels. RESULTS: Serum PSA levels and prostate volume parameters in the two groups had similar values: the median (5th-95th percentiles) serum PSA level was 1.56 ng/ml (0.12-9.77) for SCI patients and 1.04 ng/ml (0.50-2.98) for controls (P=0.481), whereas the median (5th-95th percentiles) prostate volume was 18.33 ml (10.16-76.78) for SCI patients and 20.80 ml (14.23-41.22) for controls (P=0.072). No significant differences were found when serum PSA levels and prostate volumes were compared according to SCI patient injury characteristics. Testosterone levels were lower than the normal range in 7 SCI patients (35%), LH was higher than the normal range in 10 SCI patients (20%), and FSH was higher than the normal range in eight SCI patients (40%). We observed an age-related increase in FSH levels (r=0.634, P=0.004), although hormone levels did not correlate with serum PSA levels and prostate volume parameters. CONCLUSIONS: According to our results, serum PSA levels and prostate volume in Korean SCI patients are not different from those in uninjured men and are not affected by injury characteristics.

العلاقة: Spinal Cord. 2008; 46(1): 11-15; 1362-4393 (Print); http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17387315Test; http://www.nature.com/sc/journal/v46/n1/pdf/3102051a.pdfTest; https://hdl.handle.net/10371/67944Test

الإتاحة: https://doi.org/10.1038/sj.sc.3102051Test
https://hdl.handle.net/10371/67944Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=17387315Test
http://www.nature.com/sc/journal/v46/n1/pdf/3102051a.pdfTest

المؤلفون: Cohen, J., Zhang, X., Francis, J., Jung, T., Kwok, R., Overland, J., Ballinger, T. J., Bhatt, U. S., Chen, H. W., Coumou, D., Feldstein, S., Gu, H., Handorf, D., Henderson, G., Ionita, M., Kretschmer, Marlene, Laliberte, F., Lee, S., Linderholm, H. W., Maslowski, W., Peings, Y., Pfeiffer, K., Rigor, I., Semmler, T., Stroeve, J., Taylor, P. C., Vavrus, S., Vihma, T., Wang, S., Wendisch, M., Wu, Y., Yoon, J.

الوصف: The Arctic has warmed more than twice as fast as the global average since the late twentieth century, a phenomenon known as Arctic amplification (AA). Recently, there have been considerable advances in understanding the physical contributions to AA, and progress has been made in understanding the mechanisms that link it to midlatitude weather variability. Observational studies overwhelmingly support that AA is contributing to winter continental cooling. Although some model experiments support the observational evidence, most modelling results show little connection between AA and severe midlatitude weather or suggest the export of excess heating from the Arctic to lower latitudes. Divergent conclusions between model and observational studies, and even intramodel studies, continue to obfuscate a clear understanding of how AA is influencing midlatitude weather.

العلاقة: Cohen, J. orcid:0000-0002-7762-4482 , Zhang, X. orcid:0000-0001-5893-2888 , Francis, J., Jung, T. orcid:0000-0002-2651-1293 , Kwok, R., Overland, J., Ballinger, T. J. orcid:0000-0002-8722-1927 , Bhatt, U. S., Chen, H. W. orcid:0000-0002-8601-6024 , Coumou, D., Feldstein, S., Gu, H., Handorf, D., Henderson, G. orcid:0000-0001-6835-5658 , Ionita, M., Kretschmer, M. orcid:0000-0002-2756-9526 , Laliberte, F., Lee, S., Linderholm, H. W. orcid:0000-0002-1522-8919 , Maslowski, W., Peings, Y., Pfeiffer, K., Rigor, I., Semmler, T. orcid:0000-0002-2254-4901 , Stroeve, J., Taylor, P. C. orcid:0000-0002-8098-8447 , Vavrus, S., Vihma, T. orcid:0000-0002-6557-7084 , Wang, S. orcid:0000-0003-2009-2275 , Wendisch, M. orcid:0000-0002-4652-5561 , Wu, Y. and Yoon, J. (2019) Divergent consensuses on Arctic amplification influence on midlatitude severe winter weather. Nature Climate Change, 10 (1). pp. 20-29. ISSN 1758-678X doi: https://doi.org/10.1038/s41558-019-0662-yTest

الإتاحة: https://doi.org/10.1038/s41558-019-0662-yTest
https://centaur.reading.ac.uk/98538Test/

المؤلفون: Ziegelberger, G., Baum, C., Borkhardt, A., Cobaleda, C., Dasenbrock, C., Dehos, A., Grosche, B., Hauer, J., Hornhardt, S., Jung, T., Kammertoens, T., Lagroye, I., Lehrach, H., Lightfoot, T., Little, M.P., Rossig, C., Sanchez-Garcia, I., Schrappe, M., Schuez, J., Shalapour, S., Slany, R., Stanulla, M., Weiss, W.

المساهمون: Laboratoire de l'intégration, du matériau au système (IMS), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut Polytechnique de Bordeaux-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Bioélectromagnétisme, École Pratique des Hautes Études (EPHE), Université Paris Sciences et Lettres (PSL)-Université Paris Sciences et Lettres (PSL)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)

المصدر: ISSN: 2044-5385 ; Blood Cancer Journal ; https://hal.science/hal-00628014Test ; Blood Cancer Journal, 2011, pp.1-6. ⟨10.1038/bcj.2010.1⟩.

مصطلحات موضوعية: [SDV.BBM.BP]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Biophysics, [SDV.TOX]Life Sciences [q-bio]/Toxicology

الوصف: International audience

العلاقة: hal-00628014; https://hal.science/hal-00628014Test; PUBMEDCENTRAL: PMC3255247

الإتاحة: https://doi.org/10.1038/bcj.2010.1Test
https://hal.science/hal-00628014Test

المؤلفون: Hrabe de Angelis, M. H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock, T., Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, Andreas David, Schughart, K., Pfeffer, K., Wolf, E., Balling, Rudi

المصدر: Nature Genetics, 25 (4), 444-7 (2000)

مصطلحات موضوعية: Animals, Crosses, Genetic, Cryopreservation, Ethylnitrosourea/pharmacology, Female, Forelimb/abnormalities, Genome, Immunity/genetics/immunology, Immunoglobulin E/blood, Immunoglobulin G/blood, Immunoglobulin M/blood, Male, Mice, Inbred C3H, Inbred C57BL, Mutagenesis, Mutagens/pharmacology, Mutation/drug effects/genetics/immunology, Phenotype, Life sciences, Genetics & genetic processes, Sciences du vivant, Génétique & processus génétiques

الوصف: peer reviewed ; In the post-genome era, the mouse will have a major role as a model system for functional genome analysis. This requires a large number of mutants similar to the collections available from other model organisms such as Drosophila melanogaster and Caenorhabditis elegans. Here we report on a systematic, genome-wide, mutagenesis screen in mice. As part of the German Human Genome Project, we have undertaken a large-scale ENU-mutagenesis screen for dominant mutations and a limited screen for recessive mutations. In screening over 14,000 mice for a large number of clinically relevant parameters, we recovered 182 mouse mutants for a variety of phenotypes. In addition, 247 variant mouse mutants are currently in genetic confirmation testing and will result in additional new mutant lines. This mutagenesis screen, along with the screen described in the accompanying paper, leads to a significant increase in the number of mouse models available to the scientific community. Our mutant lines are freely accessible to non-commercial users (for information, see http://www.gsf.de/ieg/groups/enu-mouse.htmlTest).

العلاقة: urn:issn:1546-1718; https://orbilu.uni.lu/handle/10993/1551Test; info:hdl:10993/1551; scopus-id:2-s2.0-0034425715; info:pmid: 10932192; wos:000088615000023

الإتاحة: https://doi.org/10.1038/78146Test
https://orbilu.uni.lu/handle/10993/1551Test

المؤلفون: de Angelis, M.H., Flaswinkel, H., Fuchs, H., Rathkolb, B., Soewarto, D., Marschall, S., Heffner, S., Pargent, W., Wuensch, K., Jung, M., Reis, A., Richter, T., Alessandrini, F., Jakob, T., Fuchs, E., Kolb, H., Kremmer, E., Schaeble, K., Rollinski, B., Roscher, A., Peters, C., Meitinger, T., Strom, T., Steckler, T., Holsboer, F., Klopstock, T., Gekeler, F., Schindewolf, C., Jung, T., Avraham, K., Behrendt, H., Ring, J., Zimmer, A., Schughart, K., Pfeffer, K., Wolf, E., Balling, R.

العلاقة: Genome-wide, large-scale production of mutant mice by ENU mutagenesis. de Angelis, M.H. and Flaswinkel, H. and Fuchs, H. and Rathkolb, B. and Soewarto, D. and Marschall, S. and Heffner, S. and Pargent, W. and Wuensch, K. and Jung, M. and Reis, A. and Richter, T. and Alessandrini, F. and Jakob, T. and Fuchs, E. and Kolb, H. and Kremmer, E. and Schaeble, K. and Rollinski, B. and Roscher, A. and Peters, C. and Meitinger, T. and Strom, T. and Steckler, T. and Holsboer, F. and Klopstock, T. and Gekeler, F. and Schindewolf, C. and Jung, T. and Avraham, K. and Behrendt, H. and Ring, J. and Zimmer, A. and Schughart, K. and Pfeffer, K. and Wolf, E. and Balling, R. Nature Genetics 25 : 444-447. 1 August 2000

الإتاحة: https://doi.org/10.1038/78146Test
http://edoc.mdc-berlin.de/4529Test/
https://edoc.mdc-berlin.de/4529Test/