Microstructure of the retinal pigment epithelium near-infrared autofluorescence in healthy young eyes and in patients with AMD
| العنوان: | Microstructure of the retinal pigment epithelium near-infrared autofluorescence in healthy young eyes and in patients with AMD |
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| المؤلفون: | Ethan A. Rossi, Kunal K. Dansingani, Kari V. Vienola, Min Zhang, Valerie Snyder, José-Alain Sahel |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, genetic structures, Visual Acuity, lcsh:Medicine, Retinal Pigment Epithelium, 01 natural sciences, Article, 010309 optics, Macular Degeneration, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Optical coherence tomography, Ophthalmology, 0103 physical sciences, Humans, Medicine, In patient, Optical techniques, Fluorescein Angiography, lcsh:Science, Multidisciplinary, Retinal pigment epithelium, medicine.diagnostic_test, business.industry, lcsh:R, Retinal, Middle Aged, Macular degeneration, medicine.disease, Retinal diseases, Healthy Volunteers, eye diseases, Scanning laser ophthalmoscopy, Autofluorescence, medicine.anatomical_structure, chemistry, Case-Control Studies, Retinal Cone Photoreceptor Cells, 030221 ophthalmology & optometry, Female, lcsh:Q, sense organs, business, Biomedical engineering, Tomography, Optical Coherence, Visual phototransduction |
| الوصف: | Retinal pigmented epithelial (RPE) cells are essential for maintaining normal visual function, especially in their role in the visual cycle, and are thought to be one of the first cell classes affected by age-related macular degeneration (AMD). Clinical imaging systems routinely evaluate the structure of the RPE at the tissue level, but cellular level information may provide valuable RPE biomarkers of health, aging and disease. In this exploratory study, participants were imaged with 795 nm excitation in adaptive optics scanning laser ophthalmoscopy (AOSLO) to observe the microstructure of the near-infrared autofluorescence (AO-IRAF) from the RPE layer in healthy retinas and patients with AMD. The expected hexagonal mosaic of RPE cells was only sometimes seen in normal eyes, while AMD patients exhibited highly variable patterns of altered AO-IRAF. In some participants, AO-IRAF structure corresponding to cones was observed, as we have demonstrated previously. In some AMD patients, marked alterations in the pattern of AO-IRAF could be seen even in areas where the RPE appeared relatively normal in clinical imaging modalities, such as spectral domain optical coherence tomography (SD-OCT). AO-IRAF imaging using AOSLO offers promise for better detection and understanding of early RPE changes in the course of AMD, potentially before clinical signs appear. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbd0f1f9ab22fa7304a907d1ff779f9Test http://link.springer.com/article/10.1038/s41598-020-66581-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bcbd0f1f9ab22fa7304a907d1ff779f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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