Corporeal Compression at the Onset of Septic shock (COCOONs): a compression method to reduce fluid balance of septic shock patients
| العنوان: | Corporeal Compression at the Onset of Septic shock (COCOONs): a compression method to reduce fluid balance of septic shock patients |
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| المؤلفون: | Auguste Dargent, Audrey Large, Agnès Soudry-Faure, Jean-Marc Doise, Caroline Abdulmalak, Lysiane Jonval, Pascal Andreu, Jean-Baptiste Roudaut, Sébastien Prin, Pierre-Emmanuel Charles, Didier Payen, Jean-Pierre Quenot, The COCOONs study group |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-8 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Critical Care, medicine.medical_treatment, lcsh:Medicine, Pilot Projects, Therapeutics, Article, Phase II trials, law.invention, Sepsis, 03 medical and health sciences, Plateau pressure, 0302 clinical medicine, law, Compression Bandages, medicine, Clinical endpoint, Humans, Prospective Studies, Prospective cohort study, lcsh:Science, Aged, Mechanical ventilation, Multidisciplinary, business.industry, Septic shock, lcsh:R, Middle Aged, Water-Electrolyte Balance, medicine.disease, Respiration, Artificial, Shock, Septic, Intensive care unit, 030104 developmental biology, Anesthesia, Shock (circulatory), Female, lcsh:Q, medicine.symptom, business, 030217 neurology & neurosurgery |
| الوصف: | Fluid overload in septic intensive care unit (ICU) patients is common and strongly associated with poor outcome. There is currently no treatment for capillary leak, which is mainly responsible for high positive fluid balance (FB) in sepsis. We hypothesized that increasing interstitial pressure with extensive corporeal compression would reduce FB. The objective of this study was to evaluate the feasibility, efficacy, and safety of a compression treatment during sepsis. This pilot, two-center, single-arm trial enrolled critically ill, non-surgical, septic patients receiving mechanical ventilation. The therapeutic intervention was the early application of compression bandages on more than 80% of the body surface. The primary outcome was negative net FB on day 7. The primary endpoint was reached in 29 of 45 patients (64%) with available data, for a planned objective of 26. By day 4, cumulative FB was 7280 ml [3300–9700]. SOFA- and aged-matched patients from a historical cohort had a significantly higher FB at 1, 2 and 7 days. Tolerance was good, although low-stage pressure ulcers were observed in 16 patients (26%). No effect on intra-abdominal pressure or respiratory plateau pressure was observed. In conclusion, corporeal compression demonstrated potential efficacy in limiting FB during septic shock, with acceptable feasibility and tolerance. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::104b3fd97a11b34d480a2bc9440ba096Test http://link.springer.com/article/10.1038/s41598-019-47939-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....104b3fd97a11b34d480a2bc9440ba096 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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