دورية أكاديمية
Comparative genomic analysis of three Leishmania species that cause diverse human disease.
| العنوان: | Comparative genomic analysis of three Leishmania species that cause diverse human disease. |
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| المؤلفون: | Peacock, Christopher S, Seeger, Kathy, Harris, David, Murphy, Lee, Peters, Nick, Adlem, Ellen, Tivey, Adrian, Aslett, Martin, Kerhornou, Arnaud, Ivens, Alasdair, Fraser, Audrey, Rajandream, Marie-Adele, Carver, Tim, Norbertczak, Halina, Chillingworth, Tracey, Hance, Zahra, Jagels, Kay, Moule, Sharon, Ormond, Doug, Rutter, Simon, Squares, Rob, Whitehead, Sally, Rabbinowitsch, Ester, Arrowsmith, Claire, White, Brian, Thurston, Scott, Bringaud, Frédéric, Baldauf, Sandra L, Faulconbridge, Adam, Jeffares, Daniel, Depledge, Daniel P, Oyola, Samuel O, Hilley, James D, Brito, Loislene O, Tosi, Luiz R O, Barrell, Barclay, Cruz, Angela K, Mottram, Jeremy C, Smith, Deborah F, Berriman, Matthew |
| المساهمون: | Microbiologie cellulaire et moléculaire et pathogénicité (MCMP), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Fogarty International Center, National Institutes of Health Bethesda (NIH), Department of Biology York, University of York York, UK |
| المصدر: | ISSN: 1061-4036. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2007 |
| المجموعة: | Archive ouverte HAL (Hyper Article en Ligne, CCSD - Centre pour la Communication Scientifique Directe) |
| مصطلحات موضوعية: | [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology |
| الوصف: | International audience ; Leishmania parasites cause a broad spectrum of clinical disease. Here we report the sequencing of the genomes of two species of Leishmania: Leishmania infantum and Leishmania braziliensis. The comparison of these sequences with the published genome of Leishmania major reveals marked conservation of synteny and identifies only approximately 200 genes with a differential distribution between the three species. L. braziliensis, contrary to Leishmania species examined so far, possesses components of a putative RNA-mediated interference pathway, telomere-associated transposable elements and spliced leader-associated SLACS retrotransposons. We show that pseudogene formation and gene loss are the principal forces shaping the different genomes. Genes that are differentially distributed between the species encode proteins implicated in host-pathogen interactions and parasite survival in the macrophage. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/17572675; hal-00169316; https://hal.archives-ouvertes.fr/hal-00169316Test; PUBMED: 17572675 |
| DOI: | 10.1038/ng2053 |
| الإتاحة: | https://doi.org/10.1038/ng2053Test https://hal.archives-ouvertes.fr/hal-00169316Test |
| رقم الانضمام: | edsbas.5EC806BA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/ng2053 |
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