دورية أكاديمية
Critical assessment of protein intrinsic disorder prediction
| العنوان: | Critical assessment of protein intrinsic disorder prediction |
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| المؤلفون: | Necci, Marco, Piovesan, Damiano, Hoque, Md Tamjidul, Walsh, Ian, Iqbal, Sumaiya, Vendruscolo, Michele, Sormanni, Pietro, Wang, Chen, Raimondi, Daniele, Sharma, Ronesh, Zhou, Yaoqi, Litfin, Thomas, Galzitskaya, Oxana Valerianovna, Lobanov, Michail Yu., Vranken, Wim, Wallner, Björn, Mirabello, Claudio, Malhis, Nawar, Dosztányi, Zsuzsanna, Erdős, Gábor, Mészáros, Bálint, Gao, Jianzhao, Wang, Kui, Hu, Gang, Wu, Zhonghua, Sharma, Alok, Hanson, Jack, Paliwal, Kuldip, Callebaut, Isabelle, Bitard-Feildel, Tristan, Orlando, Gabriele, Peng, Zhenling, Xu, Jinbo, Wang, Sheng, Jones, David T., Cozzetto, Domenico, Meng, Fanchi, Yan, Jing, Gsponer, Jörg, Cheng, Jianlin, Wu, Tianqi, Kurgan, Lukasz, Promponas, Vasilis J., Tamana, Stella, Marino, Cristina Ester, Martinez Perez, Elizabeth, Chasapi, Anastasia, Ouzounis, Christos, Dunker, A. Keith, Kajava, Andrey V., Leclercq, Jeremy Y., Aykac-Fas, Burcu, Lambrughi, Matteo, Maiani, Emiliano, Papaleo, Elena, Chemes, Lucia Beatriz, Álvarez, Lucía, González Foutel, Nicolás Sebastián, Iglesias, Valentin, Pujols, Jordi, Ventura, Salvador, Palopoli, Nicolás, Benítez, Guillermo Ignacio, Parisi, Gustavo Daniel, Bassot, Claudio, Elofsson, Arne, Govindarajan, Sudha, Lamb, John, Salvatore, Marco, Hatos, András, Monzon, Alexander Miguel, Bevilacqua, Martina, Mi?eti?, Ivan, Minervini, Giovanni, Paladin, Lisanna, Quaglia, Federica, Leonardi, Emanuela, Davey, Norman, Horvath, Tamas, Kovacs, Orsolya Panna, Murvai, Nikoletta, Pancsa, Rita, Schad, Eva, Szabo, Beata, Tantos, Agnes, Macedo Ribeiro, Sandra, Manso, Jose Antonio, Pereira, Pedro José Barbosa, Davidović, Radoslav, Veljkovic, Nevena, Hajdu Soltész, Borbála, Pajkos, Mátyás, Szaniszló, Tamás, Guharoy, Mainak, Lazar, Tamas, Macossay Castillo, Mauricio, Tompa, Peter, Tosatto, Silvio C. E. |
| بيانات النشر: | Nature Publishing Group |
| المجموعة: | CONICET Digital (Consejo Nacional de Investigaciones Científicas y Técnicas) |
| مصطلحات موضوعية: | Intrinsically disordered proteins, disorder, CAID, disorder prediction, https://purl.org/becyt/ford/1.7Test, https://purl.org/becyt/ford/1Test |
| الوصف: | Intrinsically disordered proteins, defying the traditional protein structure–function paradigm, are a challenge to study experimentally. Because a large part of our knowledge rests on computational predictions, it is crucial that their accuracy is high. The Critical Assessment of protein Intrinsic Disorder prediction (CAID) experiment was established as a community-based blind test to determine the state of the art in prediction of intrinsically disordered regions and the subset of residues involved in binding. A total of 43 methods were evaluated on a dataset of 646 proteins from DisProt. The best methods use deep learning techniques and notably outperform physicochemical methods. The top disorder predictor has Fmax = 0.483 on the full dataset and Fmax = 0.792 following filtering out of bona fide structured regions. Disordered binding regions remain hard to predict, with Fmax = 0.231. Interestingly, computing times among methods can vary by up to four orders of magnitude. ; Fil: Necci, Marco. Università di Padova; Italia ; Fil: Piovesan, Damiano. Università di Padova; Italia ; Fil: Hoque, Md Tamjidul. University of New Orleans; Estados Unidos ; Fil: Walsh, Ian. No especifíca; ; Fil: Iqbal, Sumaiya. No especifíca; ; Fil: Vendruscolo, Michele. University of Cambridge; Estados Unidos ; Fil: Sormanni, Pietro. University of Cambridge; Estados Unidos ; Fil: Wang, Chen. Columbia University; Estados Unidos ; Fil: Raimondi, Daniele. Katholikie Universiteit Leuven; Bélgica ; Fil: Sharma, Ronesh. No especifíca; ; Fil: Zhou, Yaoqi. Griffith University; Australia ; Fil: Litfin, Thomas. Griffith University; Australia ; Fil: Galzitskaya, Oxana Valerianovna. No especifíca; ; Fil: Lobanov, Michail Yu. No especifíca; ; Fil: Vranken, Wim. No especifíca; ; Fil: Wallner, Björn. Linköping University; Suecia ; Fil: Mirabello, Claudio. Linköping University; Suecia ; Fil: Malhis, Nawar. No especifíca; ; Fil: Dosztányi, Zsuzsanna. Eötvös University; Hungría ; Fil: Erdős, Gábor. Eötvös University; Hungría ; Fil: Mészáros, Bálint. ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1548-7091 |
| العلاقة: | info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41592-021-01117-3Test; http://hdl.handle.net/11336/143754Test; Necci, Marco; Piovesan, Damiano; Hoque, Md Tamjidul; Walsh, Ian; Iqbal, Sumaiya; et al.; Critical assessment of protein intrinsic disorder prediction; Nature Publishing Group; Nature Methods; 18; 5; 4-2021; 472-481; CONICET Digital; CONICET |
| الإتاحة: | https://doi.org/10.1038/s41592-021-01117-3Test http://hdl.handle.net/11336/143754Test |
| حقوق: | info:eu-repo/semantics/openAccess ; https://creativecommons.org/licenses/by/2.5/arTest/ |
| رقم الانضمام: | edsbas.95F4A362 |
| قاعدة البيانات: | BASE |
| تدمد: | 15487091 |
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