Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer
| العنوان: | Controlling Nutritional Status (CONUT) score is a prognostic factor in patients with resected breast cancer |
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| المؤلفون: | Yunfu Deng, Ting Wang, Dan Pu, Wen Li, Min Li, Qinghua Zhou, Zhenkun Liu, Guangzhi Ma, Qiang Wu, Xuejuan Liu |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, medicine.medical_specialty, Prognostic factor, Multivariate analysis, Neutrophils, Nutritional Status, lcsh:Medicine, Breast Neoplasms, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Internal medicine, Biomarkers, Tumor, medicine, Humans, In patient, Lymphocyte Count, Lymphocytes, lcsh:Science, Lymph node, Mastectomy, Serum Albumin, Survival analysis, Aged, Neoplasm Staging, Retrospective Studies, Cancer, Multidisciplinary, business.industry, lcsh:R, Nutritional status, Retrospective cohort study, Middle Aged, Prognosis, medicine.disease, Survival Analysis, Cholesterol, medicine.anatomical_structure, ROC Curve, Area Under Curve, Surgical oncology, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, lcsh:Q, Lymph Nodes, business |
| الوصف: | The present study aimed to determine the correlation between controlling nutritional status (CONUT) and prognosis in resected breast cancer patients. Totally, 861 breast cancer patients with surgical resection in West China Hospital of Sichuan University between 2007 and 2010 were included. The relationship between CONUT and various clinicopathological factors as well as prognosis was evaluated. The results showed that the optimal cutoff value for CONUT to predict the 5-year survival was 3 and CONUT had a higher area under the ROC curve (AUC) for 5-year disease free survival (DFS) and overall survival (OS) prediction compared with the neutrophil lymphocyte ratio (NLR) and prognostic nutritional index (PNI). High CONUT was significantly correlated with older age, lymph node involvement, advanced T-stage, and surgery type. In the multivariate analysis, CONUT-high patients had worse DFS and OS, when compared with CONUT-low patients. In conclusion, preoperative CONUT is a useful marker for predicting long term outcomes in breast cancer patients after curative resection. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e075b06dabb1d60678b67cd1bd732dcaTest http://link.springer.com/article/10.1038/s41598-020-63610-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e075b06dabb1d60678b67cd1bd732dca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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