Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level; a study on hCG overexpressing transgenic mice
| العنوان: | Fetal but not adult Leydig cells are susceptible to adenoma formation in response to persistently high hCG level; a study on hCG overexpressing transgenic mice |
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| المؤلفون: | Susana B Rulli, Jorma Toppari, Ilpo Huhtaniemi, Ramin Shariatmadari, Matti Poutanen, Lauri J. Pelliniemi, Petteri Ahtiainen |
| المصدر: | CONICET Digital (CONICET) Consejo Nacional de Investigaciones Científicas y Técnicas instacron:CONICET |
| بيانات النشر: | Nature Publishing Group, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Male, Cancer Research, Testicle, Human chorionic gonadotropin, Mice, Testis, Fetal Leydig Cell, Chorionic Gonadotropin, beta Subunit, Human, Tumor, biology, Leydig cell, Hcg, Gene Expression Regulation, Developmental, Leydig Cells, purl.org/becyt/ford/3.1 [https], Lipocalins, Up-Regulation, Gene Expression Regulation, Neoplastic, Intramolecular Oxidoreductases, Medicina Básica, medicine.anatomical_structure, Phenotype, purl.org/becyt/ford/3 [https], Gonadotropin, Luteinizing hormone, hormones, hormone substitutes, and hormone antagonists, Adenoma, medicine.medical_specialty, endocrine system, CIENCIAS MÉDICAS Y DE LA SALUD, 3-Hydroxysteroid Dehydrogenases, medicine.drug_class, Inmunología, Mice, Transgenic, Adult Leydig Cell, Prostaglandin-D synthase, Fetus, Internal medicine, Genetics, medicine, Animals, Humans, Molecular Biology, medicine.disease, Endocrinology, Glycoprotein Hormones, alpha Subunit, biology.protein, Thrombospondins |
| الوصف: | We have previously demonstrated that male transgenic (TG) mice overexpressing human chorionic gonadotropin (hCG+) develop reproductive organ defects, but no tumors, in adult age. In this study, the effects of persistently elevated hCG were followed in TG males between day 5 postpartum and adulthood. Leydig cell (LC) adenomas were found in prepubertal mice, most prominently at the age of 10 days, but not in adult age. Serum testosterone concentrations were significantly increased in TG males at all ages studied. The phenotype of the prepubertal hCG+ males resembled that found in boys upon expression of constitutively activating luteinizing hormone (LH) receptor mutations. The temporal expression patterns of the fetal LC marker gene, thrombospondin 2, and those of adult LCs, hydroxysteroid dehydrogenase-6, delta5-3-beta and prostaglandin D synthase, were similar in wild-type and hCG+ males. Hence, the postnatal adenomas resemble functionally fetal LCs, and only these cells are susceptible to hCG-induced tumorigenesis. Our findings demonstrate a novel intriguing difference between the fetal and adult LC populations and provide further insight into the potential tumorigenic effects of gonadotropins. Fil: Ahtianen, Petteri. University of Turku; Finlandia Fil: Rulli, Susana Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina Fil: Shariatmadari, Ramin. University of Turku; Finlandia Fil: Pelliniemi, Lauri J.. University of Turku; Finlandia Fil: Toppari, Jorma. University of Turku; Finlandia Fil: Poutanen, Matti. University of Turku; Finlandia Fil: Huhtaniemi, Ilpo T.. University of Turku; Finlandia. Imperial College London; Reino Unido |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e375463560cddc22e2bed8e5a7f1c5e3Test https://www.nature.com/articles/1208893Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e375463560cddc22e2bed8e5a7f1c5e3 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |