دورية أكاديمية
Genome-wide association study identifies multiple susceptibility loci for multiple myeloma.
| العنوان: | Genome-wide association study identifies multiple susceptibility loci for multiple myeloma. |
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| المؤلفون: | Mitchell, JS, Li, N, Weinhold, N, Försti, A, Ali, M, van Duin, M, Thorleifsson, G, Johnson, DC, Chen, B, Halvarsson, B-M, Gudbjartsson, DF, Kuiper, R, Stephens, OW, Bertsch, U, Broderick, P, Campo, C, Einsele, H, Gregory, WA, Gullberg, U, Henrion, M, Hillengass, J, Hoffmann, P, Jackson, GH, Johnsson, E, Jöud, M, Kristinsson, SY, Lenhoff, S, Lenive, O, Mellqvist, U-H, Migliorini, G, Nahi, H, Nelander, S, Nickel, J, Nöthen, MM, Rafnar, T, Ross, FM, da Silva Filho, MI, Swaminathan, B, Thomsen, H, Turesson, I, Vangsted, A, Vogel, U, Waage, A, Walker, BA, Wihlborg, A-K, Broyl, A, Davies, FE, Thorsteinsdottir, U, Langer, C, Hansson, M, Kaiser, M, Sonneveld, P, Stefansson, K, Morgan, GJ, Goldschmidt, H, Hemminki, K, Nilsson, B, Houlston, RS |
| المساهمون: | Li, Ni, Johnson, David, Broderick, Peter, Kaiser, Martin, Houlston, Richard |
| بيانات النشر: | NATURE PUBLISHING GROUP |
| سنة النشر: | 2017 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Humans, Multiple Myeloma, Genetic Predisposition to Disease, Ubiquitin-Protein Ligases, Adaptor Proteins, Signal Transducing, Guanine Nucleotide Exchange Factors, Transcription Factors, Case-Control Studies, Cyclin-Dependent Kinase Inhibitor p16, Cyclin-Dependent Kinase Inhibitor p18, Genome-Wide Association Study, Polycomb Repressive Complex 2, RNA, Long Noncoding, Autophagy-Related Protein 5 |
| الوصف: | Multiple myeloma (MM) is a plasma cell malignancy with a significant heritable basis. Genome-wide association studies have transformed our understanding of MM predisposition, but individual studies have had limited power to discover risk loci. Here we perform a meta-analysis of these GWAS, add a new GWAS and perform replication analyses resulting in 9,866 cases and 239,188 controls. We confirm all nine known risk loci and discover eight new loci at 6p22.3 (rs34229995, P=1.31 × 10(-8)), 6q21 (rs9372120, P=9.09 × 10(-15)), 7q36.1 (rs7781265, P=9.71 × 10(-9)), 8q24.21 (rs1948915, P=4.20 × 10(-11)), 9p21.3 (rs2811710, P=1.72 × 10(-13)), 10p12.1 (rs2790457, P=1.77 × 10(-8)), 16q23.1 (rs7193541, P=5.00 × 10(-12)) and 20q13.13 (rs6066835, P=1.36 × 10(-13)), which localize in or near to JARID2, ATG5, SMARCD3, CCAT1, CDKN2A, WAC, RFWD3 and PREX1. These findings provide additional support for a polygenic model of MM and insight into the biological basis of tumour development. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic; ?; application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | Nature communications, 2016, 7 pp. 12050 - ?; https://repository.icr.ac.uk/handle/internal/396Test |
| DOI: | 10.1038/ncomms12050 |
| الإتاحة: | https://doi.org/10.1038/ncomms12050Test https://repository.icr.ac.uk/handle/internal/396Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.7BA8E5F8 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/ncomms12050 |