CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia
| العنوان: | CorMatrix Wrapped Around the Adventitia of the Arteriovenous Fistula Outflow Vein Attenuates Venous Neointimal Hyperplasia |
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| المؤلفون: | Sanjay Misra, Evelyn Nieves Torres, Akshaar Brahmbhatt, Edward B. Leof, Binxia Yang, Sreenivasulu Kilari, Debabrata Mukhopadhyay, Deborah McCall |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Neointima, medicine.medical_specialty, Adventitia, medicine.medical_treatment, 030232 urology & nephrology, Lumen (anatomy), Arteriovenous fistula, lcsh:Medicine, Apoptosis, Mice, Transgenic, 030204 cardiovascular system & hematology, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Renal Dialysis, Internal medicine, Jugular vein, medicine, Leukocytes, Animals, cardiovascular diseases, Renal Insufficiency, Chronic, Myofibroblasts, lcsh:Science, Cell Proliferation, Neointimal hyperplasia, Multidisciplinary, Hyperplasia, Tissue Scaffolds, business.industry, Tumor Necrosis Factor-alpha, Macrophages, lcsh:R, Fibroblasts, medicine.disease, Extracellular Matrix, medicine.anatomical_structure, Carotid Arteries, Arteriovenous Fistula, Models, Animal, Cardiology, cardiovascular system, lcsh:Q, Hemodialysis, Jugular Veins, business, Myofibroblast |
| الوصف: | Venous neointimal hyperplasia (VNH) at the outflow vein of hemodialysis AVF is a major factor contributing to failure. CorMatrix is an extracellular matrix that has been used in cardiovascular procedures primarily as scaffolding during surgery. In the present study, we sought to determine whether CorMatrix wrapped around the outflow vein of arteriovenous fistula (AVF) at the time of creation could reduce VNH. In mice, the carotid artery to the ipsilateral jugular vein was connected to create an AVF, and CorMatrix scaffold was wrapped around the outflow vein compared to control mice that received no scaffolding. Immunohistochemistry, Western blot, and qRT-PCR were performed on the outflow vein at 7 and 21 days after AVF creation. In outflow veins treated with CorMatrix, there was an increase in the mean lumen vessel area with a decrease in the ratio of neointima area/media + adventitia area (P P Tnf-α gene expression (P |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f44aa67627d7249603d9fc23c7102e12Test http://link.springer.com/article/10.1038/s41598-017-14696-zTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f44aa67627d7249603d9fc23c7102e12 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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