Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients
| العنوان: | Autoimmune disease associated IFIH1 single nucleotide polymorphism related with IL-18 serum levels in Chinese systemic lupus erythematosus patients |
|---|---|
| المؤلفون: | Hengxu Wu, Junlong Zhang, Bin Yang, Yongkang Wu, Yanming Meng, Lanlan Wang, Xinle Liu |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, China, Interferon-Induced Helicase, IFIH1, endocrine system diseases, lcsh:Medicine, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Granzymes, Article, Pathogenesis, 03 medical and health sciences, Genotype, medicine, Humans, Lupus Erythematosus, Systemic, Allele, skin and connective tissue diseases, lcsh:Science, Autoimmune disease, Multidisciplinary, business.industry, lcsh:R, Interleukin-18, Middle Aged, medicine.disease, Type I interferon production, Granzyme B, 030104 developmental biology, Immunology, Female, Interleukin 18, lcsh:Q, business |
| الوصف: | Systemic lupus erythematosus (SLE) has heterogeneous clinical manifestations. IFIH1 (interferon induced with helicase C domain 1) as one of antiviral helicase genes mediating type I interferon production, plays an essential role in the pathogenesis of SLE. The gene variants in IFIH1 could abnormally activate antiviral defenses and increased type I interferon signaling. The present study aimed to validate associations between single nucleotide polymorphisms (SNP) in IFIH1 and the pathogenesis of SLE. In total, rs1990760, rs3747517 and rs10930046 in IFIH1 are genotyped in 400 SLE patients and 659 health controls in Chinese cohort by an improved multiplex ligation detection reaction (iMLDR) technique. Significant associations were observed between alleles of IFIH1 (rs1990760 C > T, P = 0.005, OR = 1.36, 95%CI = 1.10–1.69; rs3747517 T > C, P = 0.004, OR = 1.31, 95%CI = 1.09–1.58, respectively) and SLE susceptibility. IFIH1 rs1990760 TT genotype carriers had lower serum levels of IL-18 (P |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8df457700451dfda20d0f288cd3cdd3fTest http://link.springer.com/article/10.1038/s41598-018-27782-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8df457700451dfda20d0f288cd3cdd3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
|---|