Correlations between gut microbiota community structures of Tibetans and geography
| العنوان: | Correlations between gut microbiota community structures of Tibetans and geography |
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| المؤلفون: | Xianrong Xiong, Cai Huang, Mei Fu, Jiangjiang Zhu, Tserang Donko Mipam, Chen Yabing, Dawei Zhang, Daoliang Lan, Zhixin Cai, Wenhui Ji, Ying Li, Baoshan Lin, Yi Ai, Jian Li, Bo Zeng |
| المصدر: | Scientific Reports, Vol 7, Iss 1, Pp 1-9 (2017) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Operational taxonomic unit, Adolescent, Firmicutes, lcsh:Medicine, Gut flora, Tibet, Article, Body Mass Index, Actinobacteria, Feces, 03 medical and health sciences, Prevotella, Humans, Child, Author Correction, lcsh:Science, Principal Component Analysis, Multidisciplinary, biology, Ecology, Altitude, lcsh:R, Age Factors, Infant, Newborn, Infant, Bacteroidetes, Middle Aged, biology.organism_classification, Gastrointestinal Microbiome, 030104 developmental biology, Child, Preschool, Female, lcsh:Q, Proteobacteria, Ruminococcaceae |
| الوصف: | Microbial communities of human gut directly influence health and bear adaptive potential to different geography environment and lifestyles. However, knowledge about the influences of altitude and geography on the gut microbiota of Tibetans is currently limited. In this study, fecal microbiota from 208 Tibetans across six different locations were analyzed by MiSeq sequencing; these locations included Gannan, Gangcha, Tianzhu, Hongyuan, Lhasa and Nagqu, with altitudes above sea level ranging from 2800 m to 4500 m across the Tibetan plateau. Significant differences were observed in microbial diversity and richness in different locations. At the phylum level, gut populations of Tibetans comprised Bacteroidetes (60.00%), Firmicutes (29.04%), Proteobacteria (5.40%), and Actinobacteria (3.85%) and were marked by a low ratio (0.48) of Firmicutes to Bacteroidetes. Analysis based on operational taxonomic unit level revealed that core microbiotas included Prevotella, Faecalibacterium, and Blautia, whereas Prevotella predominated all locations, except Gangcha. Four community state types were detected in all samples, and they mainly belong to Prevotella, Bacteroides, and Ruminococcaceae. Principal component analysis and related correspondence analysis results revealed that bacterial profiles in Tibetan guts varied significantly with increasing altitude, BMI, and age, and facultative anaerobes were rich in Tibetan guts. Gut microbiota may play important roles in regulating high-altitude and geographical adaptations. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde9071b9166aef7c9abd00eedf38ea6Test http://link.springer.com/article/10.1038/s41598-017-17194-4Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dde9071b9166aef7c9abd00eedf38ea6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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