An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis
| العنوان: | An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis |
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| المؤلفون: | Jennifer A. Smith, Andrea A. Baccarelli, Jordana T. Bell, James B. Meigs, James S. Pankow, Jun Liu, Ayse Demirkan, Marjolein J. Peters, Jerome I. Rotter, Elias Salfati, Bertha Hidalgo, Audrey Y. Chu, André G. Uitterlinden, Luigi Ferrucci, Pooja R. Mandaviya, Nona Sotoodehnia, Eric A. Whitsel, Liesbeth Duijts, Marie-France Hivert, Elena Carnero-Montoro, Eric J.G. Sijbrands, Ann Zenobia Moore, Janine F. Felix, Jenny van Dongen, Najaf Amin, Tim D. Spector, Oscar H. Franco, Harald Grallert, Tiphaine Martin, Ivana Nedeljkovic, Josée Dupuis, Aaron Isaacs, Themistocles L. Assimes, Pei-Chien Tsai, Cornelia M. van Duijn, Lifang Hou, Daniel Levy, Ko Willems van Dijk, Rahul Gondalia, Samantha Lent, Abbas Dehghan, Rozenn N. Lemaitre, Jan Bressler, Christian Herder, Min A. Jhun, Symen Ligthart, Dorret I. Boomsma, Gonneke Willemsen, Toshiko Tanaka, Rick Jansen, Joyce B. J. van Meurs, Shih-Jen Hwang, Vincent W. V. Jaddoe, Donna K. Arnett, Eco J. C. de Geus, Henning Tiemeier, Stefania Bandinelli |
| المساهمون: | Pediatric surgery, Epidemiology and Data Science, Biological Psychology, APH - Mental Health, APH - Personalized Medicine, APH - Methodology, Epidemiology, Internal Medicine, Pediatrics, Erasmus MC other, Child and Adolescent Psychiatry / Psychology, RS: CARIM - R1 - Thrombosis and haemostasis, RS: FHML MaCSBio, Biochemie, RS: Carim - B01 Blood proteins & engineering |
| المصدر: | Liu, Jun; Carnero-Montoro, Elena; van Dongen, Jenny; Lent, Samantha; Nedeljkovic, Ivana; Ligthart, Symen; Tsai, Pei-Chien; Martin, Tiphaine C; Mandaviya, Pooja R; Jansen, Rick; Peters, Marjolein J; Duijts, Liesbeth; Jaddoe, Vincent W V; Tiemeier, Henning; Felix, Janine F; Willemsen, Gonneke; de Geus, Eco J C; Chu, Audrey Y; Levy, Daniel; Hwang, Shih-Jen; ... (2019). An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis. Nature communications, 10(1), p. 2581. Nature Publishing Group 10.1038/s41467-019-10487-4 <http://dx.doi.org/10.1038/s41467-019-10487-4Test> Nature Communications, 10(1):2581. Nature Publishing Group Liu, J, Carnero-Montoro, E, van Dongen, J, Lent, S, Nedeljkovic, I, Ligthart, S, Tsai, P-C, Martin, T C, Mandaviya, P R, Jansen, R, Peters, M J, Duijts, L, Jaddoe, V W V, Tiemeier, H, Felix, J F, Willemsen, G, de Geus, E J C, Chu, A Y, Levy, D, Hwang, S-J, Bressler, J, Gondalia, R, Salfati, E L, Herder, C, Hidalgo, B A, Tanaka, T, Moore, A Z, Lemaitre, R N, Jhun, M A, Smith, J A, Sotoodehnia, N, Bandinelli, S, Ferrucci, L, Arnett, D K, Grallert, H, Assimes, T L, Hou, L, Baccarelli, A, Whitsel, E A, van Dijk, K W, Amin, N, Uitterlinden, A G, Sijbrands, E J G, Franco, O H, Dehghan, A, Spector, T D, Dupuis, J, Hivert, M-F, Rotter, J I, Meigs, J B, Pankow, J S, van Meurs, J B J, Isaacs, A, Boomsma, D I, Bell, J T, Demirkan, A & van Duijn, C M 2019, ' An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis ', Nature Communications, vol. 10, no. 1, 2581, pp. 2581 . https://doi.org/10.1038/s41467-019-10487-4Test Nature Communications, 10. NATURE PUBLISHING GROUP Nature Communications, 10:2581. Nature Publishing Group Liu, J, Carnero-Montoro, E, van Dongen, J, Lent, S, Nedeljkovic, I, Ligthart, S, Tsai, P C, Martin, T C, Mandaviya, P R, Jansen, R, Peters, M J, Duijts, L, Jaddoe, V W V, Tiemeier, H, Felix, J F, Willemsen, G, de Geus, E J C, Chu, A Y, Levy, D, Hwang, S J, Bressler, J, Gondalia, R, Salfati, E L, Herder, C, Hidalgo, B A, Tanaka, T, Moore, A Z, Lemaitre, R N, Jhun, M A, Smith, J A, Sotoodehnia, N, Bandinelli, S, Ferrucci, L, Arnett, D K, Grallert, H, Assimes, T L, Hou, L, Baccarelli, A, Whitsel, E A, van Dijk, K W, Amin, N, Uitterlinden, A G, Sijbrands, E J G, Franco, O H, Dehghan, A, Spector, T D, Dupuis, J, Hivert, M F, Rotter, J I, Meigs, J B, Pankow, J S, van Meurs, J B J, Isaacs, A, Boomsma, D I, Bell, J T, Demirkan, A & van Duijn, C M 2019, ' An integrative cross-omics analysis of DNA methylation sites of glucose and insulin homeostasis ', Nature Communications, vol. 10, 2581, pp. 1-11 . https://doi.org/10.1038/s41467-019-10487-4Test Nature Communications, 10:2581, 1-11. Nature Publishing Group Nat. Commun. 10:2581 (2019) Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019) Nature Communications |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Epigenomics, Male, Netherlands Twin Register (NTR), medicine.medical_treatment, General Physics and Astronomy, 02 engineering and technology, Type 2 diabetes, UP-REGULATION, Epigenesis, Genetic, Glucose homeostasis, Homeostasis, Insulin, lcsh:Science, Genetics, Aged, 80 and over, Multidisciplinary, Middle Aged, 021001 nanoscience & nanotechnology, 3. Good health, Multidisciplinary Sciences, DNA methylation, Science & Technology - Other Topics, Epigenetics, Female, 0210 nano-technology, WAIST CIRCUMFERENCE, Metabolic Networks and Pathways, Adult, EXPRESSION, Science, 610 Medicine & health, Biology, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Young Adult, TYPE-2, SDG 3 - Good Health and Well-being, 360 Social problems & social services, Diabetes mellitus, medicine, GLYCEMIC TRAITS, Humans, Computer Simulation, Obesity, Transcriptomics, Aged, EPIGENOME-WIDE ASSOCIATION, Science & Technology, Gene Expression Profiling, DIABETES-MELLITUS, General Chemistry, DNA Methylation, medicine.disease, GENE, IRS2, BODY-MASS INDEX, 030104 developmental biology, Glucose, Diabetes Mellitus, Type 2, Gene Expression Regulation, lcsh:Q, CpG Islands, Genome-Wide Association Study, FASTING GLUCOSE |
| الوصف: | Despite existing reports on differential DNA methylation in type 2 diabetes (T2D) and obesity, our understanding of its functional relevance remains limited. Here we show the effect of differential methylation in the early phases of T2D pathology by a blood-based epigenome-wide association study of 4808 non-diabetic Europeans in the discovery phase and 11,750 individuals in the replication. We identify CpGs in LETM1, RBM20, IRS2, MAN2A2 and the 1q25.3 region associated with fasting insulin, and in FCRL6, SLAMF1, APOBEC3H and the 15q26.1 region with fasting glucose. In silico cross-omics analyses highlight the role of differential methylation in the crosstalk between the adaptive immune system and glucose homeostasis. The differential methylation explains at least 16.9% of the association between obesity and insulin. Our study sheds light on the biological interactions between genetic variants driving differential methylation and gene expression in the early pathogenesis of T2D. Our understanding of the functional link between differential DNA methylation and type 2 diabetes and obesity remains limited. Here the authors present a blood-based EWAS of fasting glucose and insulin among 4808 non-diabetic Europeans and identify nine CpGs not previously implicated in glucose, insulin homeostasis and diabetes. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1c4c694350da37c4a64da57355aac00Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....e1c4c694350da37c4a64da57355aac00 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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