دورية أكاديمية
Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice
| العنوان: | Kindlin-2 loss in condylar chondrocytes causes spontaneous osteoarthritic lesions in the temporomandibular joint in mice |
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| المؤلفون: | Yumei Lai, Wei Zheng, Minghao Qu, Christopher C. Xiao, Sheng Chen, Qing Yao, Weiyuan Gong, Chu Tao, Qinnan Yan, Peijun Zhang, Xiaohao Wu, Guozhi Xiao |
| المصدر: | International Journal of Oral Science, Vol 14, Iss 1, Pp 1-10 (2022) |
| بيانات النشر: | Nature Publishing Group, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Dentistry |
| مصطلحات موضوعية: | Dentistry, RK1-715 |
| الوصف: | Abstract The progressive destruction of condylar cartilage is a hallmark of the temporomandibular joint (TMJ) osteoarthritis (OA); however, its mechanism is incompletely understood. Here, we show that Kindlin-2, a key focal adhesion protein, is strongly detected in cells of mandibular condylar cartilage in mice. We find that genetic ablation of Kindlin-2 in aggrecan-expressing condylar chondrocytes induces multiple spontaneous osteoarthritic lesions, including progressive cartilage loss and deformation, surface fissures, and ectopic cartilage and bone formation in TMJ. Kindlin-2 loss significantly downregulates the expression of aggrecan, Col2a1 and Proteoglycan 4 (Prg4), all anabolic extracellular matrix proteins, and promotes catabolic metabolism in TMJ cartilage by inducing expression of Runx2 and Mmp13 in condylar chondrocytes. Kindlin-2 loss decreases TMJ chondrocyte proliferation in condylar cartilages. Furthermore, Kindlin-2 loss promotes the release of cytochrome c as well as caspase 3 activation, and accelerates chondrocyte apoptosis in vitro and TMJ. Collectively, these findings reveal a crucial role of Kindlin-2 in condylar chondrocytes to maintain TMJ homeostasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1674-2818 2049-3169 |
| العلاقة: | https://doaj.org/toc/1674-2818Test; https://doaj.org/toc/2049-3169Test |
| DOI: | 10.1038/s41368-022-00185-1 |
| الوصول الحر: | https://doaj.org/article/e511152728c54ceb868b6aafe19d408fTest |
| رقم الانضمام: | edsdoj.511152728c54ceb868b6aafe19d408f |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 16742818 20493169 |
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| DOI: | 10.1038/s41368-022-00185-1 |