Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis
| العنوان: | Interleukin-26 activates macrophages and facilitates killing of Mycobacterium tuberculosis |
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| المؤلفون: | Hawerkamp, Heike C., van Geelen, Lasse, Korte, Jan, Di Domizio, Jeremy, Swidergall, Marc, Momin, Afaque A., Guzmán-Vega, Francisco J., Arold, Stefan T., Ernst, Joachim, Gilliet, Michel, Kalscheuer, Rainer, Homey, Bernhard, Meller, Stephan |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) Scientific reports, vol 10, iss 1 Scientific Reports Scientific Reports, vol. 10, no. 1 |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, THP-1 Cells, Mononuclear, Messenger, lcsh:Medicine, Inflammatory diseases, Article, Cell Line, Rare Diseases, Leukocytes, 2.1 Biological and endogenous factors, Humans, Tuberculosis, RNA, Messenger, Aetiology, lcsh:Science, Aged, Multidisciplinary, Tumor Necrosis Factor-alpha, Inflammatory and immune system, Macrophages, Interleukins, lcsh:R, Dendritic Cells, Mycobacterium tuberculosis, Middle Aged, Infectious Diseases, Good Health and Well Being, HEK293 Cells, Leukocytes, Mononuclear, HIV/AIDS, RNA, Cytokines, Female, lcsh:Q, Infection |
| الوصف: | Tuberculosis-causing Mycobacterium tuberculosis (Mtb) is transmitted via airborne droplets followed by a primary infection of macrophages and dendritic cells. During the activation of host defence mechanisms also neutrophils and T helper 1 (TH1) and TH17 cells are recruited to the site of infection. The TH17 cell-derived interleukin (IL)-17 in turn induces the cathelicidin LL37 which shows direct antimycobacterial effects. Here, we investigated the role of IL-26, a TH1- and TH17-associated cytokine that exhibits antimicrobial activity. We found that both IL-26 mRNA and protein are strongly increased in tuberculous lymph nodes. Furthermore, IL-26 is able to directly kill Mtb and decrease the infection rate in macrophages. Binding of IL-26 to lipoarabinomannan might be one important mechanism in extracellular killing of Mtb. Macrophages and dendritic cells respond to IL-26 with secretion of tumor necrosis factor (TNF)-α and chemokines such as CCL20, CXCL2 and CXCL8. In dendritic cells but not in macrophages cytokine induction by IL-26 is partly mediated via Toll like receptor (TLR) 2. Taken together, IL-26 strengthens the defense against Mtb in two ways: firstly, directly due to its antimycobacterial properties and secondly indirectly by activating innate immune mechanisms. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1e13041c6cc298ea4d8119cb98ba325bTest http://link.springer.com/article/10.1038/s41598-020-73989-yTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....1e13041c6cc298ea4d8119cb98ba325b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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