Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci

التفاصيل البيبلوغرافية
العنوان: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
المؤلفون: Rosalind A. Eeles, Karina Dalsgaard Sørensen, Torben F. Ørntoft, Jeri Kim, Wayne D. Tilley, Ruth C. Travis, Lorelei A. Mucci, Jenny L Donovan, Kay-Tee Khaw, Edward Giovannucci, Christopher I. Amos, Soo Hwang Teo, Claire Aukim-Hastie, Gerald L. Andriole, Linda Steele, Martin Eklund, Guomin Wang, Michael Borre, Antonio Finelli, Liesel M. FitzGerald, Thérèse Truong, Robert N. Hoover, Sandeep Singhal, Radka Kaneva, Frank Claessens, Robert Szulkin, Javier Llorca, Dominika Wokołorczyk, Esther M. John, Daniel J. Schaid, Jyotsna Batra, Kathryn L. Penney, Børge G. Nordestgaard, Catharine M L West, Hermann Brenner, Sue A. Ingles, Markus Aly, Jonathan Tyrer, Thomas J. Schnoeller, Xin Guo, Peter Iversen, Olivier Cussenot, Laurence N. Kolonel, Henrik Grönberg, Ninghan Feng, Geraldine Cancel-Tassin, Christiane Maier, David E. Neal, Marija Gamulin, Ezequiel Anokian, Christopher J. Logothetis, Shannon K. McDonnell, Lovise Maehle, Anssi Auvinen, Antonio Gómez-Caamaño, Tomislav Kuliš, Manuel Luedeke, Teuvo L.J. Tammela, Brian D. Carter, Zan Sun, Jong Y. Park, Nawaid Usmani, Ian M. Thompson, Zuxi Cui, Johanna Schleutker, Bernd Holleczek, Davor Lessel, Katarina Cuk, Eli Marie Grindedal, Milan S. Geybels, Yuan Chun Ding, Phyllis J. Goodman, Jing Ma, Paul A. Townsend, Edward J. Saunders, Melissa C. Southey, Graham G. Giles, Robert J. Hamilton, Laura Fachal, Mitchell J. Machiela, Demetrius Albanes, Gert De Meerleer, Paula Paulo, Agnieszka Michael, Yves Akoli Koudou, Janet L. Stanford, Kim De Ruyck, Thomas Van den Broeck, Tokhir Dadaev, Clara Cieza-Borrella, Sonja I. Berndt, Artitaya Lophatananon, Brian E. Henderson, Niclas Håkansson, Christopher A. Haiman, Florence Menegaux, Xueying Mao, Jan Lubinski, Elio Riboli, Paul D.P. Pharoah, David J. Hunter, Loic Le Marchand, Stephen N. Thibodeau, Fredrik Wiklund, Tobias Nordström, Thomas A. Sellers, Chee Goh, Elaine A. Ostrander, Sune F. Nielsen, Neil E. Fleshner, Neil G. Burnet, Rasmus Bisbjerg, Manuela Gago Dominguez, Csilla Sipeky, Maria Elena Martinez, Susan L. Neuhausen, Stephen J. Chanock, Hui Yi Lin, Laura E. Beane Freeman, A. Siddiq, Alicja Wolk, Gemma Castaño-Vinyals, Lisa F. Newcomb, Catherine M. Tangen, Ana Vega, Peter Kraft, Chavdar Slavov, Daniel Leongamornlert, Lisa A. Cannon-Albright, Stella Koutros, Manuel R. Teixeira, Susan M. Gapstur, Federico Canzian, Sara Lindström, Maren Weischer, Bettina F. Drake, Lisa G. Horvath, Daniel W. Lin, Jose Esteban Castelao, Yong-Jie Lu, Xin Sheng, Vanio Mitev, Ron H.N. van Schaik, Monique J. Roobol, Zsofia Kote-Jarai, Leire Moya, Alison M. Dunning, Mahbubl Ahmed, Kenneth Muir, Douglas F. Easton, Suzanne K. Chambers, Hongwei Zhang, Jianfeng Xu, Jasmine Lim, Meir J. Stampfer, Guido Jenster, Ali Amin Al Olama, Victoria L. Stevens, Sara Benlloch, Mark N. Brook, Azad Hassan Abdul Razack, Marta Cardoso, Matthew Parliament, Gail P. Risbridger, Samantha E.T. Larkin, Fredrick R. Schumacher, Martin Andreas Røder, Harry Ostrer, Judith A. Clements, Manolis Kogevinas, Barry S. Rosenstein, Steven Joniau, Richard M. Martin, Constance Turman, Mariana C. Stern, Joe Dennis, David V. Conti, Sarah L. Kerns, Adam S. Kibel, Robert J. MacInnis, Stephanie J. Weinstein, Freddie C. Hamdy, Cezary Cybulski, Nora Pashayan, Timothy J. Key, Hardev Pandha, Piet Ost
المساهمون: Urology, Clinical Chemistry, Imperial College Trust, Schumacher, Fredrick R [0000-0002-3073-7463], Apollo - University of Cambridge Repository
المصدر: Schumacher, F R, Al Olama, A A, Berndt, S I, Benlloch, S, Ahmed, M, Saunders, E J, Dadaev, T, Leongamornlert, D, Anokian, E, Cieza-Borrella, C, Goh, C, Brook, M N, Sheng, X, Fachal, L, Dennis, J, Tyrer, J, Muir, K, Lophatananon, A, Stevens, V L, Gapstur, S M, Carter, B D, Tangen, C M, Goodman, P J, Thompson, I M, Batra, J, Chambers, S, Moya, L, Clements, J, Horvath, L, Tilley, W, Risbridger, G P, Gronberg, H, Aly, M, Nordström, T, Pharoah, P, Pashayan, N, Schleutker, J, Tammela, T L J, Sipeky, C, Auvinen, A, Albanes, D, Weinstein, S, Wolk, A, Sorensen, K D, Orntoft, T F, Borre, M & Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8Test
the Profile Study 2018, ' Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci ', Nature Genetics, vol. 50, no. 7, 8, pp. 928-936 . https://doi.org/10.1038/s41588-018-0142-8Test
Nature Genetics, 50(7), 928-+. Nature Publishing Group
بيانات النشر: Nature Publishing Group, 2018.
سنة النشر: 2018
مصطلحات موضوعية: 0301 basic medicine, Oncology, Male, PREDICTION, Cancer of the Prostate in Sweden (CAPS), Genome-wide association study, PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, VARIANTS, Australian Prostate Cancer BioResource (APCB), urologic and male genital diseases, DISEASE, FAMILY-HISTORY, PATHWAY, Prostate cancer, Prostate Cancer Genome-wide Association Study of Uncommon Susceptibility Loci (PEGASUS), 11 Medical and Health Sciences, Genetics & Heredity, RISK, education.field_of_study, Profile Study, IMPACT Study, 3. Good health, prostate cancer (PrCa)-susceptibility loci, Centre for Surgical Research, BIOLOGICAL PATHWAYS, ICEP, Life Sciences & Biomedicine, Medical Genetics, Risk, medicine.medical_specialty, Genotype, Population, Biology, Polymorphism, Single Nucleotide, 03 medical and health sciences, MULTIPLE LOCI, Breast and Prostate Cancer Cohort Consortium (BPC3), SDG 3 - Good Health and Well-being, Internal medicine, Genetic model, Genetics, medicine, Humans, Genetic Predisposition to Disease, GENOME-WIDE ASSOCIATION, education, Genotyping, METAANALYSIS, Medicinsk genetik, Genetic association, Canary PASS Investigators, Science & Technology, IDENTIFICATION, CONSORTIUM, Case-control study, Prostatic Neoplasms, 06 Biological Sciences, medicine.disease, GENE, Genetic Associations and Mechanisms in Oncology (GAME-ON)/Elucidating Loci Involved in Prostate Cancer Susceptibility (ELLIPSE) Consortium, 030104 developmental biology, Genetic Loci, Relative risk, Case-Control Studies, genotype, humans, male, Developmental Biology, Genome-Wide Association Study
الوصف: Genome-wide association studies (GWAS) and fine-mapping efforts to date have identified more than 100 prostate cancer (PrCa)-susceptibility loci. We meta-analyzed genotype data from a custom high-density array of 46,939 PrCa cases and 27,910 controls of European ancestry with previously genotyped data of 32,255 PrCa cases and 33,202 controls of European ancestry. Our analysis identified 62 novel loci associated (P < 5.0 × 10-8) with PrCa and one locus significantly associated with early-onset PrCa (≤55 years). Our findings include missense variants rs1800057 (odds ratio (OR) = 1.16; P = 8.2 × 10-9; G>C, p.Pro1054Arg) in ATM and rs2066827 (OR = 1.06; P = 2.3 × 10-9; T>G, p.Val109Gly) in CDKN1B. The combination of all loci captured 28.4% of the PrCa familial relative risk, and a polygenic risk score conferred an elevated PrCa risk for men in the ninetieth to ninety-ninth percentiles (relative risk = 2.69; 95% confidence interval (CI): 2.55-2.82) and first percentile (relative risk = 5.71; 95% CI: 5.04-6.48) risk stratum compared with the population average. These findings improve risk prediction, enhance fine-mapping, and provide insight into the underlying biology of PrCa 1 .
وصف الملف: application/pdf; text; application/vnd.openxmlformats-officedocument.wordprocessingml.document
تدمد: 1546-1718
1061-4036
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::440cb385cd9e0ed608a7b8e0cf8117c2Test
https://pure.eur.nl/en/publications/b6f972b4-fdcb-43dc-a43a-ac5dd4f050e6Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....440cb385cd9e0ed608a7b8e0cf8117c2
قاعدة البيانات: OpenAIRE