Author Correction: Characterizing rare and low-frequency height-associated variants in the Japanese population
| العنوان: | Author Correction: Characterizing rare and low-frequency height-associated variants in the Japanese population |
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| المؤلفون: | Masahiro Kanai, Naoko Minegishi, Kazuyoshi Ishigaki, Masayuki Yamamoto, Masato Akiyama, Kozo Tanno, Mariko Naito, Atsushi Hozawa, Kenji Wakai, Yukinori Okada, Yukihide Momozawa, Atsushi Shimizu, Shiro Ikegawa, Yoichiro Kamatani, Sadao Suzuki, Momoko Horikoshi, Saori Sakaue, Michiaki Kubo, Yoshinori Murakami, Koichi Matsuda, Makoto Hirata, Taiki Yamaji, Daisuke Matsui, Atsushi Takahashi, Norie Sawada, Shoichiro Tsugane, Makoto Sasaki, Motoki Iwasaki |
| المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-1 (2020) Nature Communications |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, Genotype, Science, Quantitative Trait Loci, MEDLINE, General Physics and Astronomy, Biology, Quantitative trait, Genome-wide association studies, Polymorphism, Single Nucleotide, General Biochemistry, Genetics and Molecular Biology, Asian People, Gene Frequency, Japan, Humans, Author Correction, lcsh:Science, Multidisciplinary, Published Erratum, Genetic Variation, Rare variants, General Chemistry, Retinoic Acid 4-Hydroxylase, Japanese population, Fatty Acid Transport Proteins, Body Height, Phenotype, Heritable quantitative trait, Female, lcsh:Q, Genome-Wide Association Study, Demography |
| الوصف: | Human height is a representative phenotype to elucidate genetic architecture. However, the majority of large studies have been performed in European population. To investigate the rare and low-frequency variants associated with height, we construct a reference panel (N = 3,541) for genotype imputation by integrating the whole-genome sequence data from 1,037 Japanese with that of the 1000 Genomes Project, and perform a genome-wide association study in 191,787 Japanese. We report 573 height-associated variants, including 22 rare and 42 low-frequency variants. These 64 variants explain 1.7% of the phenotypic variance. Furthermore, a gene-based analysis identifies two genes with multiple height-increasing rare and low-frequency nonsynonymous variants (SLC27A3 and CYP26B1; P |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d890c5197964274a3c72acc8806eaacbTest http://link.springer.com/article/10.1038/s41467-020-15202-2Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d890c5197964274a3c72acc8806eaacb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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