نتائج البحث

1

Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African Americans than Caucasians

المؤلفون: Jørgen Rungby, J K Lauridsen, Agnete Larsen, Joel E. Kleinman, Thomas M. Hyde, J Vendelbo, Rasmus H. Olesen

المصدر: The Pharmacogenomics Journal
Nielsen, J V, Olesen, R H, Lauridsen, J K, Rungby, J, Kleinmann, J, Hyde, T & Larsen, A 2016, ' Increasing BMI is associated with reduced expression of P-glycoprotein (ABCB1 gene) in the human brain with a stronger association in African-Americans than Caucasians ', The Pharmacogenomics Journal . https://doi.org/10.1038/tpj.2016.74Test

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, ATP Binding Cassette Transporter, Subfamily B, Adolescent, Pharmacology, Biology, Weight Gain, White People, Body Mass Index, Excretion, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Genetics, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, Obesity, Polymorphism, Genetic, Microarray analysis techniques, Brain, Human brain, Methylation, DNA Methylation, Middle Aged, medicine.disease, Black or African American, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, Blood-Brain Barrier, DNA methylation, Molecular Medicine, Original Article, Female, medicine.symptom, Weight gain, Body mass index, 030217 neurology & neurosurgery, Antipsychotic Agents

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b7059200fbf19a4716aa36fa5c7b1caTest
http://europepmc.org/articles/PMC5817387Test

2

A parallel-arm phase I trial of the humanised anti-IGF-1R antibody dalotuzumab in combination with the AKT inhibitor MK-2206, the mTOR inhibitor ridaforolimus, or the NOTCH inhibitor MK-0752, in patients with advanced solid tumours

المؤلفون: Jonathan D. Cheng, Lainie P. Martin, J. Fiorica, Raanan Berger, Paul Haluska, William S. Dalton, M. B. Jones, Shannon N. Westin, Lillian L. Siu, Talia Golan, J. Stephenson, Jhanelle E. Gray, Khaldoun Almhanna, R. M. Wenham, P. Hanjani, Alexandra Gunchenko, Daniel M. Sullivan, J. Edenfield, Irene Brana

المصدر: British Journal of Cancer

مصطلحات موضوعية: Male, Cancer Research, Akt inhibitor, Pharmacology, Receptor, IGF Type 1, Cohort Studies, chemistry.chemical_compound, MK-0752, Neoplasms, Antineoplastic Combined Chemotherapy Protocols, Benzene Derivatives, Medicine, Tissue Distribution, Sulfones, Randomized Controlled Trials as Topic, Aged, 80 and over, biology, Receptors, Notch, TOR Serine-Threonine Kinases, Antibodies, Monoclonal, Middle Aged, Discovery and development of mTOR inhibitors, Prognosis, ovarian cancer, Oncology, MK-2206, Female, Antibody, Heterocyclic Compounds, 3-Ring, Adult, colorectal cancer, Antibodies, Monoclonal, Humanized, Ridaforolimus, Clinical Trials, Phase II as Topic, ridaforolimus, Biomarkers, Tumor, Humans, In patient, Aged, Neoplasm Staging, dalotuzumab, Sirolimus, business.industry, Dalotuzumab, chemistry, Clinical Trials, Phase III as Topic, biology.protein, Clinical Study, Propionates, business, Proto-Oncogene Proteins c-akt, Follow-Up Studies

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f49b7b9125e9a40ceec15ef2e49d7c9Test
http://europepmc.org/articles/PMC4229637Test

3

Effect of everolimus on the immunomodulation of the human neutrophil inflammatory response and activation

المؤلفون: Damien Vitiello, Martin G. Sirois, Michel White, Paul-Eduard Neagoe

المصدر: Cellular and Molecular Immunology

مصطلحات موضوعية: Adult, Male, Vascular Endothelial Growth Factor A, Intimal hyperplasia, Neutrophils, medicine.medical_treatment, Anti-Inflammatory Agents, immunosuppressive drugs, Neovascularization, Physiologic, Pharmacology, immunology, Immunomodulation, chemistry.chemical_compound, Young Adult, Immune system, medicine, Cell Adhesion, Immunology and Allergy, Humans, human, Everolimus, Cells, Cultured, Aged, Inflammation, Sirolimus, business.industry, Myocardium, Interleukin-8, Middle Aged, medicine.disease, Coronary Vessels, cytokines, Vascular endothelial growth factor, Transplantation, Interleukin 1 Receptor Antagonist Protein, Infectious Diseases, Cytokine, chemistry, CD18 Antigens, Heart Transplantation, Tumor necrosis factor alpha, Drug Therapy, Combination, Female, business, medicine.drug, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd60db5e546021afcb8f5e6521fba86bTest
http://europepmc.org/articles/PMC4654366Test

4

ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder

المؤلفون: den Johan Boer, Pierre M. Bet, Harold Snieder, O. de Klerk, Witte J.G. Hoogendijk, Fokko J. Bosker, Ilja M. Nolte, Brenda W.J.H. Penninx, Richard Bruggeman

المساهمون: Neuroscience Campus Amsterdam - Neurobiology of Mental Health, EMGO+ - Mental Health, Perceptual and Cognitive Neuroscience (PCN), Life Course Epidemiology (LCE), Public Health, Psychiatry, Clinical pharmacology and pharmacy, NCA - Neurobiology of mental health, EMGO - Mental health

المصدر: de Klerk, O L, Nolte, I M, Bet, P M, Bosker, F J, Snieder, H, den Boer, J A, Bruggeman, R, Hoogendijk, W J G & Penninx, B W J H 2013, ' ABCB1 gene variants influence tolerance to selective serotonin reuptake inhibitors in a large sample of Dutch cases with major depressive disorder ', Pharmacogenomics Journal, vol. 13, no. 4, pp. 349-353 . https://doi.org/10.1038/tpj.2012.16Test
Pharmacogenomics Journal, 13(4), 349-353. Nature Publishing Group
Pharmacogenomics journal, 13(4), 349-353. Nature Publishing Group

مصطلحات موضوعية: Male, IMPACT, Genome-wide association study, Pharmacology, Bioinformatics, SSRI, BRAIN, Netherlands, adverse drug reactions, P-GLYCOPROTEIN, ABCB1, Middle Aged, single-nucleotide polymorphism, Antidepressive Agents, Molecular Medicine, Antidepressant, Major depressive disorder, Anxiety, Female, medicine.symptom, Selective Serotonin Reuptake Inhibitors, Adult, Serotonin, ATP Binding Cassette Transporter, Subfamily B, Drug-Related Side Effects and Adverse Reactions, Single-nucleotide polymorphism, Biology, Serotonergic, Polymorphism, Single Nucleotide, MDR1 GENE, SDG 3 - Good Health and Well-being, Genetics, medicine, Humans, ATP Binding Cassette Transporter, Subfamily B, Member 1, GENOME-WIDE ASSOCIATION, Adverse effect, Genetic Association Studies, POLYMORPHISMS, Depressive Disorder, Major, DISPOSITION, major depressive disorder, Haplotype, medicine.disease, TRANSPORTERS, Haplotypes, ANTIDEPRESSANT RESPONSE, PENETRATION

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf82128f2eeb527c2ae0ad3d03c7d2f7Test
https://doi.org/10.1038/tpj.2012.16Test

5

Association of a complement receptor 1 gene variant with baseline erythrocyte sedimentation rate levels in patients starting anti-TNF therapy in a UK rheumatoid arthritis cohort: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

المؤلفون: James Bluett, John Isaacs, Steven Young-Min, Nicholas Hopkinson, Wan-Fai Ng, Karim Raza, William Dixon, Ann Morgan, Fraser Birrell, Anne Barton, Hector Chinoy, Jon Packham, Kimme Hyrich, Raj Sengupta

المصدر: The Pharmacogenomics Journal

مصطلحات موضوعية: musculoskeletal diseases, rheumatoid arthritis, Adult, Male, Complement receptor 1, Single-nucleotide polymorphism, Immunogenetics, Blood Sedimentation, Polymorphism, Single Nucleotide, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, tumour necrosis factor-alpha, Genotype, Genetics, medicine, Humans, 030212 general & internal medicine, skin and connective tissue diseases, Aged, 030203 arthritis & rheumatology, Pharmacology, medicine.diagnostic_test, biology, business.industry, Tumor Necrosis Factor-alpha, C-reactive protein, Genomics, Middle Aged, medicine.disease, 3. Good health, immunogenetics, Europe, C-Reactive Protein, Treatment Outcome, Erythrocyte sedimentation rate, Rheumatoid arthritis, Immunology, Cohort, biology.protein, Receptors, Complement 3b, Molecular Medicine, Original Article, Female, biology.gene, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84b1b1b97af86d343fa4bdda5b68572fTest
http://europepmc.org/articles/PMC3965567Test

6

Safety, tolerability, pharmacokinetics and pharmacodynamics of AZD8055 in advanced solid tumours and lymphoma

المؤلفون: Razelle Kurzrock, Udai Banerji, Carol Aghajanian, David Olmos, Stan B. Kaye, Elisabeth Oelmann, Aung Naing, William L Burke, Robert H Taylor, Gary G Schwartz, Lynda Grinsted, Eric Raymond

المصدر: British Journal of Cancer

مصطلحات موضوعية: Drug, Adult, Male, Cancer Research, medicine.medical_specialty, mTOR inhibitors, Lymphoma, Maximum Tolerated Dose, media_common.quotation_subject, Morpholines, Mechanistic Target of Rapamycin Complex 2, Pharmacology, Mechanistic Target of Rapamycin Complex 1, Gastroenterology, Drug Administration Schedule, Cohort Studies, Stable Disease, Pharmacokinetics, Internal medicine, Neoplasms, Medicine, Humans, Dosing, Adverse effect, media_common, Aged, Dose-Response Relationship, Drug, business.industry, TOR Serine-Threonine Kinases, AZD8055, phase I, Middle Aged, medicine.disease, Oncology, Tolerability, Multiprotein Complexes, Elevated transaminases, Female, business, Translational Therapeutics

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9a485a49be57a5c43fcb8ae4edd16f1Test
http://europepmc.org/articles/PMC3461162Test

7

Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD

المساهمون: Clinical Child and Family Studies, Clinical Neuropsychology, LEARN! - Brain, learning and development, Department of Psychology, Education and Child Studies

المصدر: Neuropsychopharmacology, 35, 656-664. Nature Publishing Group
Neuropsychopharmacology, 35, 656-64
Neuropsychopharmacology
Neuropsychopharmacology, 35, 3, pp. 656-64
Boonstra, A M, Franke, B, Vasquez, A A, Johansson, S, Hoogman, M, Romanos, J & Boreatti-Hümmer, A 2010, ' Multicenter Analysis of the SLC6A3/DAT1 VNTR Haplotype in Persistent ADHD Suggests Differential Involvement of the Gene in Childhood and Persistent ADHD ', Neuropsychopharmacology, vol. 35, pp. 656-664 . https://doi.org/10.1038/npp.2009.170Test

مصطلحات موضوعية: Adult, Male, Internationality, Adolescent, Neurogenetics, Single-nucleotide polymorphism, Aetiology, screening and detection [ONCOL 5], Minisatellite Repeats, behavioral disciplines and activities, Genomic disorders and inherited multi-system disorders [IGMD 3], Young Adult, Genotype, mental disorders, Perception and Action [DCN 1], Humans, Allele, Child, Aged, Retrospective Studies, Dopamine transporter, Genetic association, Pharmacology, Genetics, Mental Health [NCEBP 9], Dopamine Plasma Membrane Transport Proteins, biology, Haplotype, Age Factors, Middle Aged, Psychiatry and Mental health, Variable number tandem repeat, Haplotypes, Evaluation of complex medical interventions [NCEBP 2], Attention Deficit Disorder with Hyperactivity, biology.protein, Female, Original Article, Psychology, Functional Neurogenomics [DCN 2]