Human T-lymphotropic virus 1 and 2 among people who used illicit drugs in the state of Pará, northern Brazil
| العنوان: | Human T-lymphotropic virus 1 and 2 among people who used illicit drugs in the state of Pará, northern Brazil |
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| المؤلفون: | Ricardo Ishak, Andreia Polliana Castro de Souza, Aldemir B. Oliveira-Filho, Emil Kupek, Luisa Caricio Martins, Gláucia C. Silva-Oliveira, Luiz Fernando Almeida Machado, José Alexandre Rodrigues de Lemos, Camila Moraes Gomes, Antonio Carlos Rosário Vallinoto, Benedikt Fischer, Ana Paula Sousa Araújo |
| المصدر: | Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, medicine.medical_specialty, Adolescent, Epidemiology, viruses, 030106 microbiology, Population, Unprotected sex, lcsh:Medicine, Article, Virus, Drug Users, Young Adult, 03 medical and health sciences, Health services, Environmental health, Prevalence, Humans, Medicine, education, lcsh:Science, High rate, Human T-lymphotropic virus 1, education.field_of_study, Multidisciplinary, High prevalence, biology, Illicit Drugs, business.industry, Human T-lymphotropic virus 2, lcsh:R, HTLV, biology.organism_classification, HTLV-I Infections, Cross-Sectional Studies, 030104 developmental biology, Risk factors, Viral infection, HTLV-II Infections, Female, lcsh:Q, business, Brazil |
| الوصف: | People who used illicit drugs (PWUDs) represent an important population group for acquisition and viral dispersion. In Brazil, high rates of the human T lymphotropic virus 1 (HTLV-1) and 2 (HTLV-2) have been reported in epidemiological studies. However, the epidemiological scenario of HTLV-1/2 infections in PWUDs is still poorly understood. Thus, this cross-sectional study determined the prevalence, frequency of subtypes and factors associated with HTLV-1/2 infections among PWUDs in the Brazilian state of Pará, an area considered endemic for this virus and with poor health services. Among 826 PWUDs, 53 (6.4%) presented anti-HTLV-1/2 antibodies by EIA and 44 (5.3%) presented proviral DNA by PCR. HTLV-1 and HTLV-2 were detected in 25 (3.0%) and 19 (2.3%) PWUDs, respectively. Subtypes 1a (25/44), transcontinental (23/44) and Japanese subgroups (2/44), 2b (6/44) and 2c (13/44) were identified. Involvement in illicit/criminal activity, daily use of illicit drugs, illicit drug use over 12 years, unprotected sex with other PWUDs, changes in genitalia (including ulcers and wounds), and more than 12 sexual partners were associated with HTLV-1/2 in PWUDs. This high prevalence and intense circulation of subtypes and subgroups of HTLV-1/2 is very worrying, and indicate the need for urgent actions for its control, prevention and treatment. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c209f3f25161845b7d27205b27abb7aTest http://link.springer.com/article/10.1038/s41598-019-51383-7Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7c209f3f25161845b7d27205b27abb7a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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