نتائج البحث

1

Identification of a novel CHN1 p.(Phe213Val) variant in a large Han Chinese family with congenital Duane retraction syndrome

المؤلفون: Li-Yun Guo, Xiao-Lin Fu, Min Hu, Zhou Yuan, Xiao-Fan Zhang, Jie Yin, Qin Zhu, Tai-Cheng Zhou, Wen-Hua Duan, Guang-Long Zhou, Xue-Jiao Li, Jie-Ying Zhang, Zhi-Juan Hua, Dongmei Yang

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)
Scientific Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43463564c722620dc1f9507d1dd242c0Test
http://link.springer.com/article/10.1038/s41598-020-73190Test-1

2

Baseline IFN-γ and IL-10 expression in PBMCs could predict response to PD-1 checkpoint inhibitors in advanced melanoma patients

المؤلفون: Davide Ciardiello, Teresa Troiani, Erika Martinelli, N. Zanaletti, Stefania Napolitano, P. Vitale, Giusi Barra, Raffaele De Palma, Vincenzo De Falco, M. Terminiello, Floriana Morgillo, Emilio Francesco Giunta, Giuseppe Argenziano, Fortunato Ciardiello

المساهمون: Giunta, Emilio Francesco, Barra, Giusi, De Falco, Vincenzo, Argenziano, Giuseppe, Napolitano, Stefania, Vitale, Pasquale, Zanaletti, Nicoletta, Terminiello, Marinella, Martinelli, Erika, Morgillo, Floriana, Ciardiello, Davide, De Palma, Raffaele, Ciardiello, Fortunato, Troiani, Teresa

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-11 (2020)
Scientific Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c64fa57985a2b5d76692b374d5b40dfTest
http://link.springer.com/article/10.1038/s41598-020-72711-2Test

3

Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia

المؤلفون: Sampada Kallol, Susana Contreras-Duarte, Jaime Gutiérrez, Andrea Leiva, Bárbara Fuenzalida, Lorena Carvajal, Christiane Albrecht, Valentina Pasten, Claudette Cantin

المصدر: Fuenzalida, Bárbara; Cantin, Claudette; Kallol, Sampada; Carvajal, Lorena; Pastén, Valentina; Contreras-Duarte, Susana; Albrecht, Christiane; Gutierrez, Jaime; Leiva, Andrea (2020). Cholesterol uptake and efflux are impaired in human trophoblast cells from pregnancies with maternal supraphysiological hypercholesterolemia. Scientific Reports, 10(1), p. 5264. Nature Publishing Group 10.1038/s41598-020-61629-4 <http://dx.doi.org/10.1038/s41598-020-61629-4Test>
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Apolipoprotein B, Placenta, lcsh:Medicine, 030204 cardiovascular system & hematology, chemistry.chemical_compound, 0302 clinical medicine, Pregnancy, lcsh:Science, 610 Medicine & health, Maternal-Fetal Exchange, Cells, Cultured, ATP Binding Cassette Transporter, Subfamily G, Member 1, Multidisciplinary, biology, medicine.diagnostic_test, Middle Aged, Fetal Blood, Trophoblasts, Cholesterol, medicine.anatomical_structure, ABCG1, embryonic structures, Female, lipids (amino acids, peptides, and proteins), ATP Binding Cassette Transporter 1, Adult, Endocrine reproductive disorders, medicine.medical_specialty, Lipoproteins, Hypercholesterolemia, Article, Young Adult, 03 medical and health sciences, Syncytiotrophoblast, Internal medicine, medicine, Humans, Triglycerides, Dyslipidaemias, Apolipoprotein A-I, business.industry, lcsh:R, Infant, Newborn, Trophoblast, nutritional and metabolic diseases, Biological Transport, Pregnancy Complications, 030104 developmental biology, Endocrinology, Receptors, LDL, chemistry, ABCA1, LDL receptor, biology.protein, 570 Life sciences, lcsh:Q, Lipid profile, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02fc3917882ccfda77e4b41df9170240Test

4

Upregulation of B7-H4 promotes tumor progression of intrahepatic cholangiocarcinoma

المؤلفون: Bi-Mang Fu, Qiang Kang, Zheng-Ji Song, Xuan Yang, Hai-Xiang Sun, Li-Xin Liu, Hao Zou, Peng-Fei Zhang, Nan Xie, Ying-Hao Shen, Ai-Wu Ke, Xiao-Yong Huang, Jia-Bin Cai, Dong-Mei Gao, Guo-Ming Shi, Jia-Cheng Lu, Lu Zhang, Xin-Yu Zhang, Chi Zhang

المصدر: Cell Death and Disease, Vol 8, Iss 12, Pp 1-13 (2017)
Cell Death & Disease

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Metastasis, Cholangiocarcinoma, 0302 clinical medicine, Medicine, Intrahepatic Cholangiocarcinoma, bcl-2-Associated X Protein, Mitogen-Activated Protein Kinase 1, Mitogen-Activated Protein Kinase 3, biology, Caspase 3, lcsh:Cytology, Middle Aged, Prognosis, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins c-bcl-2, Lymphatic Metastasis, 030220 oncology & carcinogenesis, Disease Progression, Female, Antibody, Signal Transduction, Adult, Epithelial-Mesenchymal Transition, Immunology, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, Downregulation and upregulation, Biomarkers, Tumor, Humans, Clinical significance, lcsh:QH573-671, Aged, Neoplasm Staging, Messenger RNA, business.industry, Cell Biology, V-Set Domain-Containing T-Cell Activation Inhibitor 1, medicine.disease, Survival Analysis, 030104 developmental biology, Bile Duct Neoplasms, Tumor progression, Cell culture, Cancer research, biology.protein, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6208afbf262b772f0b67b711b6d11283Test
http://link.springer.com/article/10.1038/s41419-017-0015-6Test

5

HCV-specific CD4+ T cells of patients with acute and chronic HCV infection display high expression of TIGIT and other co-inhibitory molecules

المؤلفون: Silke Kummer, William W. Kwok, Thomas Jacobs, Julian Schulze zur Wiesch, Ansgar W. Lohse, Sven Peine, Matthias Marget, Tobias Boettler, Christin Ackermann, Thomas Kuntzen, Robin Woost, Maike Smits, Johanna M. Eberhard

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

مصطلحات موضوعية: Adult, CD4-Positive T-Lymphocytes, Male, 0301 basic medicine, CD226, Programmed Cell Death 1 Receptor, BTLA, lcsh:Medicine, Hepacivirus, Immunological memory, Article, Young Adult, 03 medical and health sciences, 0302 clinical medicine, TIGIT, MHC class I, Humans, Medicine, Receptors, Immunologic, Receptor, lcsh:Science, Hepatitis A Virus Cellular Receptor 2, Aged, Multidisciplinary, biology, Hepatitis C virus, business.industry, T-cell receptor, lcsh:R, Histocompatibility Antigens Class II, virus diseases, Hepatitis C, Chronic, Middle Aged, Receptors, OX40, Hepatitis C, digestive system diseases, Chronic infection, 030104 developmental biology, Acute Disease, Immunology, biology.protein, Female, lcsh:Q, business, 030217 neurology & neurosurgery, CD8

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df54b52b1f824ed57f6415d962a118eaTest
http://link.springer.com/article/10.1038/s41598-019-47024-8Test

6

Hypoxia-induced ZEB1 promotes cervical cancer progression via CCL8-dependent tumour-associated macrophage recruitment

المؤلفون: Rui-Ming Yan, Wei Wang, Wen-Fei Wei, Luo-Jiao Liang, Mei Zhong, Sha Wu, Li Liang, Xiao-Jing Chen, Yan-Mei Zhang, Zi-Ci Wang, Yuan-Run Deng, Chen-Fei Zhou

المصدر: Cell Death and Disease, Vol 10, Iss 7, Pp 1-11 (2019)
Cell Death & Disease

مصطلحات موضوعية: Adult, Cancer microenvironment, 0301 basic medicine, Cancer Research, Chemokine, Blotting, Western, Immunology, Fluorescent Antibody Technique, Uterine Cervical Neoplasms, Enzyme-Linked Immunosorbent Assay, CCL8, Article, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Cell Line, Tumor, Tumor Microenvironment, medicine, Chemokine CCL8, Humans, Secretion, lcsh:QH573-671, Hypoxia, Cervical cancer, biology, Reverse Transcriptase Polymerase Chain Reaction, business.industry, lcsh:Cytology, Macrophages, NF-kappa B, Zinc Finger E-box-Binding Homeobox 1, Cell Biology, Middle Aged, Hypoxia (medical), medicine.disease, Immunohistochemistry, 030104 developmental biology, Checkpoint signalling, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, Disease Progression, Cancer research, biology.protein, Female, medicine.symptom, business, CD163

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::602504ef2b28a8d7887b9a6c45894da9Test
http://link.springer.com/article/10.1038/s41419-019-1748Test-1

7

Wwp2 maintains cartilage homeostasis through regulation of Adamts5

المؤلفون: Hiroshi Asahara, Yoshiaki Ito, Tokio Matsuzaki, Kohei Miyata, Tempei Sato, Martin Lotz, Ryo Nakamichi, Merissa Olmer, Eiji Sugiyama, Masafumi Inui, Sho Mokuda

المصدر: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Cartilage, Articular, CRISPR-Cas9 genome editing, Knee Joint, Ubiquitylation, General Physics and Astronomy, Core Binding Factor Alpha 1 Subunit, 02 engineering and technology, Osteoarthritis, Menisci, Tibial, Mice, Ubiquitin, lcsh:Science, Aged, 80 and over, Mice, Knockout, Multidisciplinary, biology, Cartilage homeostasis, Chemistry, Middle Aged, 021001 nanoscience & nanotechnology, musculoskeletal system, Ubiquitin ligase, Cell biology, RUNX2, medicine.anatomical_structure, miRNAs, 0210 nano-technology, Signal Transduction, Adult, musculoskeletal diseases, Ubiquitin-Protein Ligases, Science, WWP2, macromolecular substances, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Young Adult, Downregulation and upregulation, medicine, Animals, Humans, RNA, Messenger, Aged, Cartilage, Skull, Ubiquitination, General Chemistry, X-Ray Microtomography, medicine.disease, Arthritis, Experimental, Disease Models, Animal, 030104 developmental biology, biology.protein, lcsh:Q, ADAMTS5 Protein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f4c9bffffe46cfae2df3f937bdfb3f0Test
http://link.springer.com/article/10.1038/s41467-019-10177Test-1

8

Genetic Variants Associated with Episodic Ataxia in Korea

المؤلفون: Seo Young Choi, Sang-Ho Kim, Seung-Han Lee, Hyo Jung Kim, Kwang-Dong Choi, Kyung-Pil Park, Hyang-Sook Kim, Dae-Seong Kim, Ji Soo Kim, Ileok Jung, Seong-Hae Jeong, Dong Uk Kim, Jae-Hwan Choi, Jin-Hong Shin

المصدر: Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
SCIENTIFIC REPORTS(7)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Male, Candidate gene, DNA Mutational Analysis, lcsh:Medicine, CACNB4, medicine.disease_cause, 0302 clinical medicine, Child, lcsh:Science, Exome sequencing, Genetics, Mutation, Multidisciplinary, Middle Aged, Pedigree, Excitatory Amino Acid Transporter 1, Phenotype, Child, Preschool, Female, medicine.symptom, Adult, Adolescent, Ubiquitin-Protein Ligases, Biology, Article, 03 medical and health sciences, Young Adult, Republic of Korea, Exome Sequencing, medicine, Humans, Aged, Episodic ataxia, Cerebellar ataxia, Genetic heterogeneity, lcsh:R, medicine.disease, Cytoskeletal Proteins, 030104 developmental biology, biology.protein, Ataxia, Calmodulin-Binding Proteins, lcsh:Q, Calcium Channels, Kv1.1 Potassium Channel, 030217 neurology & neurosurgery, Biomarkers, Truncal ataxia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ead6df5e1f430599e747013afa45621Test
http://link.springer.com/article/10.1038/s41598-017-14254-7Test

9

DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer

المؤلفون: S Wang, Y Dong, Y Zhang, X Wang, L Xu, S Yang, X Li, H Dong, L Su, S S M Ng, Z Chang, J J Sung, X Zhang, J Yu

المصدر: Oncogene

مصطلحات موضوعية: Adult, Cancer Research, Beta-catenin, Colorectal cancer, Lymphoid Enhancer-Binding Factor 1, Nuclear Localization Signals, Active Transport, Cell Nucleus, Mutation, Missense, Mice, Nude, Disease-Free Survival, Mice, Genetics, medicine, Animals, Humans, Molecular Biology, Wnt Signaling Pathway, beta Catenin, Adaptor Proteins, Signal Transducing, Aged, Aged, 80 and over, Cell Nucleus, Mice, Inbred BALB C, biology, Cell growth, Tumor Suppressor Proteins, Wnt signaling pathway, Methylation, Middle Aged, medicine.disease, Cadherins, Molecular biology, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Survival Rate, HEK293 Cells, Amino Acid Substitution, Catenin, Colonic Neoplasms, biology.protein, Original Article, Signal transduction, Caco-2 Cells, Carrier Proteins, Lymphoid enhancer-binding factor 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::540e3517f9ace32d9fa109e0daa0b6baTest
http://europepmc.org/articles/PMC4761644Test

10

Endotoxins are associated with visceral fat mass in type 1 diabetes

المؤلفون: Mariann I. Lassenius, Aila J. Ahola, Valma Harjutsalo, Per-Henrik Groop, Markku Lehto, Carol Forsblom

المساهمون: Clinicum, Department of Medicine, Nefrologian yksikkö, Research Programs Unit, Diabetes and Obesity Research Program, Per Henrik Groop / Principal Investigator

المصدر: Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Lipopolysaccharides, Male, medicine.medical_specialty, Intra-Abdominal Fat, PROTEIN, 030209 endocrinology & metabolism, LIPOPOLYSACCHARIDE, DISEASE, Article, SERUM, 03 medical and health sciences, chemistry.chemical_compound, LIPOPROTEINS, 0302 clinical medicine, Insulin resistance, Diabetes mellitus, Internal medicine, medicine, Humans, Adiposity, RISK, Inflammation, Type 1 diabetes, INSULIN-RESISTANCE, Multidisciplinary, Triglyceride, biology, business.industry, C-reactive protein, Middle Aged, medicine.disease, Obesity, 3. Good health, 030104 developmental biology, Endocrinology, C-Reactive Protein, Diabetes Mellitus, Type 1, chemistry, OBESITY, 3121 General medicine, internal medicine and other clinical medicine, biology.protein, lipids (amino acids, peptides, and proteins), Female, business, Dyslipidemia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::10a9745abc64dc5b250d93e013b9a07eTest

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