Effect of High Intensity Interval Training on Matrix Metalloproteinases in Women with Breast Cancer Receiving Anthracycline-Based Chemotherapy
| العنوان: | Effect of High Intensity Interval Training on Matrix Metalloproteinases in Women with Breast Cancer Receiving Anthracycline-Based Chemotherapy |
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| المؤلفون: | Irene Kang, Wendy J. Mack, George J. Salem, Joanne E. Mortimer, Christina M. Dieli-Conwright, Kyuwan Lee, Fred R. Sattler |
| المصدر: | Scientific Reports, Vol 10, Iss 1, Pp 1-7 (2020) Scientific Reports |
| بيانات النشر: | Nature Publishing Group, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Oncology, medicine.medical_specialty, Anthracycline, Physiology, medicine.medical_treatment, Cardiology, lcsh:Medicine, Antineoplastic Agents, Breast Neoplasms, High-Intensity Interval Training, 030204 cardiovascular system & hematology, Matrix metalloproteinase, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Breast cancer, Matrix Metalloproteinase 10, Randomized controlled trial, law, Diabetes mellitus, Internal medicine, Humans, Medicine, Anthracyclines, lcsh:Science, Tissue Inhibitor of Metalloproteinase-2, Chemotherapy, Tissue Inhibitor of Metalloproteinase-1, Multidisciplinary, business.industry, lcsh:R, Health care, Repeated measures design, medicine.disease, Matrix Metalloproteinases, Matrix Metalloproteinase 9, Risk factors, Matrix Metalloproteinase 7, 030220 oncology & carcinogenesis, Matrix Metalloproteinase 2, Female, lcsh:Q, Matrix Metalloproteinase 1, business, High-intensity interval training |
| الوصف: | Anthracycline chemotherapy is commonly used to treat breast cancer yet may increase the level of matrix metalloproteinases (MMP) -2 and -9, which increase the risk of atherosclerosis. While exercise has been shown to reduce the level of MMP in patients with diabetes, high intensity interval training (HIIT) has not been utilized to improve level of MMP in women with breast cancer receiving anthracycline chemotherapy. Thirty women were randomized to either 8-week HIIT or control (CON) group. The CON group was offered the HIIT intervention after 8 weeks. MMP-1, -2 -7, -9, tissue inhibitor of MMP (TIMP) -1, and-2 were measured at baseline and post-intervention. Repeated measures ANCOVA and paired t-test were performed to assess changes in MMP and TIMP. Post-intervention, no significant between-group differences were observed for MMP and TIMP. However, within-group decrease in MMP-9 was observed in the HIIT group [104.3(51.9) to 65.2(69.1); P = 0.01]. MMP-9 in the CON group was not significantly changed [115.5(47.2) to 90.4(67.9);]. MMP-2 significantly increased in both the HIIT group [76.6(11.2) to 83.2(13.1); P = 0.007) and the CON group [69.0(8.9) to 77.6(11.1) P = 0.003). It is unclear whether an 8-week HIIT intervention influences MMP-9 in breast cancer patients undergoing anthracycline chemotherapy. Additional investigations are required to understand the exercise-induced changes in MMP-2 and -9 in women undergoing anthracycline chemotherapy. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3cc9848316dfd3cf0c820b086f93c3fTest http://link.springer.com/article/10.1038/s41598-020-61927-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3cc9848316dfd3cf0c820b086f93c3f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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