دورية أكاديمية
Shared heritability and functional enrichment across six solid cancers
| العنوان: | Shared heritability and functional enrichment across six solid cancers |
|---|---|
| المؤلفون: | Jiang, Xia, Finucane, Hilary K., Schumacher, Fredrick R., Schmit, Stephanie L., Tyrer, Jonathan P., Han, Younghun, Michailidou, Kyriaki, Lesseur, Corina, Kuchenbaecker, Karoline B., Dennis, Joe, Conti, David V., Casey, Graham, Gaudet, Mia M., Huyghe, Jeroen R., Albanes, Demetrius, Aldrich, Melinda C., Andrew, Angeline S., Andrulis, Irene L., Anton-Culver, Hoda, Antoniou, Antonis C., Antonenkova, Natalia N., Arnold, Susanne M., Aronson, Kristan J., Arun, Banu K., Bandera, Elisa V., Barkardottir, Rosa B., Barnes, Daniel R., Batra, Jyotsna, Beckmann, Matthias W., Benitez, Javier, Benlloch, Sara, Berchuck, Andrew, Berndt, Sonja I., Bickeboeller, Heike, Bien, Stephanie A., Blomqvist, Carl, Boccia, Stefania, Bogdanova, Natalia V., Bojesen, Stig E., Bolla, Manjeet K., Brauch, Hiltrud, Brenner, Hermann, Brenton, James D., Brook, Mark N., Brunet, Joan, Brunnstrom, Hans, Buchanan, Daniel D., Burwinkel, Barbara, Butzow, Ralf, Cadoni, Gabriella, Caldes, Trinidad, Caligo, Maria A., Campbell, Ian, Campbell, Peter T., Cancel-Tassin, Geraldine, Cannon-Albright, Lisa, Campa, Daniele, Caporaso, Neil, Carvalho, Andre L., Chan, Andrew T., Chang-Claude, Jenny, Chanock, Stephen J., Chen, Chu, Christiani, David C., Claes, Kathleen B. M., Claessens, Frank, Clements, Judith, Collee, J. Margriet, Correa, Marcia Cruz, Couch, Fergus J., Cox, Angela, Cunningham, Julie M., Cybulski, Cezary, Czene, Kamila, Daly, Mary B., defazio, Anna, Devilee, Peter, Diez, Orland, Gago-Dominguez, Manuela, Donovan, Jenny L., Doerk, Thilo, Duell, Eric J., Dunning, Alison M., Dwek, Miriam, Eccles, Diana M., Edlund, Christopher K., Edwards, Digna R. Velez, Ellberg, Carolina, Evans, D. Gareth, Fasching, Peter A., Ferris, Robert L., Liloglou, Triantafillos, Figueiredo, Jane C., Fletcher, Olivia, Fortner, Renee T., Fostira, Florentia, Franceschi, Silvia, Friedman, Eitan, Gallinger, Steven J., Ganz, Patricia A., Garber, Judy, Garcia-Saenz, Jose A., Gayther, Simon A., Giles, Graham G., Godwin, Andrew K., Goldberg, Mark S., Goldgar, David E., Goode, Ellen L., Goodman, Marc T., Goodman, Gary, Grankvist, Kjell, Greene, Mark H., Gronberg, Henrik, Gronwald, Jacek, Guenel, Pascal, Hakansson, Niclas, Hall, Per, Hamann, Ute, Hamdy, Freddie C., Hamilton, Robert J., Hampe, Jochen, Haugen, Aage, Heitz, Florian, Herrero, Rolando, Hillemanns, Peter, Hoffmeister, Michael, Hogdall, Estrid, Hong, Yun-Chul, Hopper, John L., Houlston, Richard, Hulick, Peter J., Hunter, David J., Huntsman, David G., Idos, Gregory, Imyanitov, Evgeny N., Ingles, Sue Ann, Isaacs, Claudine, Jakubowska, Anna, James, Paul, Jenkins, Mark A., Johansson, Mattias, Johansson, Mikael, John, Esther M., Joshi, Amit D., Kaneva, Radka, Karlan, Beth Y., Kelemen, Linda E., Kuhl, Tabea, Khaw, Kay-Tee, Khusnutdinova, Elza, Kibel, Adam S., Kiemeney, Lambertus A., Kim, Jeri, Kjaer, Susanne K., Knight, Julia A., Kogevinas, Manolis, Kote-Jarai, Zsofia, Koutros, Stella, Kristensen, Vessela N., Kupryjanczyk, Jolanta, Lacko, Martin, Lam, Stephan, Lambrechts, Diether, Landi, Maria Teresa, Lazarus, Philip, Le, Nhu D., Lee, Eunjung, Lejbkowicz, Flavio, Lenz, Heinz-Josef, Leslie, Goska, Lessel, Davor, Lester, Jenny, Levine, Douglas A., Li, Li, Li, Christopher I., Lindblom, Annika, Lindor, Noralane M., Liu, Geoffrey, Loupakis, Fotios, Lubinski, Jan, Maehle, Lovise, Maier, Christiane, Mannermaa, Arto, Le Marchand, Loic, Margolin, Sara, May, Taymaa, McGuffog, Lesley, Meindl, Alfons, Middha, Pooja, Miller, Austin, Milne, Roger L., MacInnis, Robert J., Modugno, Francesmary, Montagna, Marco, Moreno, Victor, Moysich, Kirsten B., Mucci, Lorelei, Muir, Kenneth, Mulligan, Anna Marie, Nathanson, Katherine L., Neal, David E., Ness, Andrew R., Neuhausen, Susan L., Nevanlinna, Heli, Newcomb, Polly A., Newcomb, Lisa F., Nielsen, Finn Cilius, Nikitina-Zake, Liene, Nordestgaard, Borge G., Nussbaum, Robert L., Offit, Kenneth, Olah, Edith, Al Olama, Ali Amin, Olopade, Olufunmilayo I., Olshan, Andrew F., Olsson, Hakan, Osorio, Ana, Pandha, Hardev, Park, Jong Y., Pashayan, Nora, Parsons, Michael T., Pejovic, Tanja, Penney, Kathryn L., Peters, Wilbert H. M., Phelan, Catherine M., Phipps, Amanda I., Plaseska-Karanfilska, Dijana, Pring, Miranda, Prokofyeva, Darya, Radice, Paolo, Stefansson, Kari, Ramus, Susan J., Raskin, Leon, Rennert, Gad, Rennert, Hedy S., van Rensburg, Elizabeth J., Riggan, Marjorie J., Risch, Harvey A., Risch, Angela, Roobol, Monique J., Rosenstein, Barry S., Rossing, Mary Anne, De Ruyck, Kim, Saloustros, Emmanouil, Sandler, Dale P., Sawyer, Elinor J., Schabath, Matthew B., Schleutker, Johanna, Schmidt, Marjanka K., Setiawan, V. Wendy, Shen, Hongbing, Siegel, Erin M., Sieh, Weiva, Singer, Christian F., Slattery, Martha L., Sorensen, Karina Dalsgaard, Southey, Melissa C., Spurdle, Amanda B., Stanford, Janet L., Stevens, Victoria L., Stintzing, Sebastian, Stone, Jennifer, Sundfeldt, Karin, Sutphen, Rebecca, Swerdlow, Anthony J., Tajara, Eloiza H., Tangen, Catherine M., Tardon, Adonina, Taylor, Jack A., Teare, M. Dawn, Teixeira, Manuel R., Terry, Mary Beth, Terry, Kathryn L., Thibodeau, Stephen N., Thomassen, Mads, Bjorge, Line, Tischkowitz, Marc, Toland, Amanda E., Torres, Diana, Townsend, Paul A., Travis, Ruth C., Tung, Nadine, Tworoger, Shelley S., Ulrich, Cornelia M., Usmani, Nawaid, Vachon, Celine M., Van Nieuwenhuysen, Els, Vega, Ana, Aguado-Barrera, Miguel Elias, Wang, Qin, Webb, Penelope M., Weinberg, Clarice R., Weinstein, Stephanie, Weissler, Mark C., Weitzel, Jeffrey N., West, Catharine M. L., White, Emily, Whittemore, Alice S., Wichmann, H-Erich, Wiklund, Fredrik, Winqvist, Robert, Wolk, Alicja, Woll, Penella, Woods, Michael, Wu, Anna H., Wu, Xifeng, Yannoukakos, Drakoulis, Zheng, Wei, Zienolddiny, Shanbeh, Ziogas, Argyrios, Zorn, Kristin K., Lane, Jacqueline M., Saxena, Richa, Thomas, Duncan, Hung, Rayjean J., Diergaarde, Brenda, Mckay, James, Peters, Ulrike, Hsu, Li, Garcia-Closas, Montserrat, Eeles, Rosalind A., Chenevix-Trench, Georgia, Brennan, Paul J., Haiman, Christopher A., Simard, Jacques, Easton, Douglas F., Gruber, Stephen B., Pharoah, Paul D. P., Price, Alkes L., Pasaniuc, Bogdan, Amos, Christopher I., Kraft, Peter, Lindstrom, Sara |
| المساهمون: | Clinicum, Department of Oncology, University of Helsinki, Department of Pathology, Medicum, Department of Obstetrics and Gynecology, HUS Comprehensive Cancer Center |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2019 |
| المجموعة: | Helsingfors Universitet: HELDA – Helsingin yliopiston digitaalinen arkisto |
| مصطلحات موضوعية: | GENOME-WIDE ASSOCIATION, SUSCEPTIBILITY LOCI, BREAST-CANCER, RISK-FACTORS, LUNG-CANCER, PARTITIONING HERITABILITY, MENDELIAN RANDOMIZATION, GENETIC ARCHITECTURE, ANALYSES IDENTIFY, CELL-TYPES, 3111 Biomedicine, 1184 Genetics, developmental biology, physiology, 3122 Cancers |
| الوصف: | Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (r(g) = 0.57, p = 4.6 x 10(-8)), breast and ovarian cancer (r(g) = 0.24, p = 7 x 10(-5)), breast and lung cancer (r(g) = 0.18, p = 1.5 x 10(-6)) and breast and colorectal cancer (r(g) = 0.15, p = 1.1 x 10(-4)). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis. ; Peer reviewed |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Jiang , X , Finucane , H K , Schumacher , F R , Schmit , S L , Tyrer , J P , Han , Y , Michailidou , K , Lesseur , C , Kuchenbaecker , K B , Dennis , J , Conti , D V , Casey , G , Gaudet , M M , Huyghe , J R , Albanes , D , Aldrich , M C , Andrew , A S , Andrulis , I L , Anton-Culver , H , Antoniou , A C , Antonenkova , N N , Arnold , S M , Aronson , K J , Arun , B K , Bandera , E V , Barkardottir , R B , Barnes , D R , Batra , J , Beckmann , M W , Benitez , J , Benlloch , S , Berchuck , A , Berndt , S I , Bickeboeller , H , Bien , S A , Blomqvist , C , Boccia , S , Bogdanova , N V , Bojesen , S E , Bolla , M K , Brauch , H , Brenner , H , Brenton , J D , Brook , M N , Brunet , J , Brunnstrom , H , Buchanan , D D , Burwinkel , B , Butzow , R , Cadoni , G , Caldes , T , Caligo , M A , Campbell , I , Campbell , P T , Cancel-Tassin , G , Cannon-Albright , L , Campa , D , Caporaso , N , Carvalho , A L , Chan , A T , Chang-Claude , J , Chanock , S J , Chen , C , Christiani , D C , Claes , K B M , Claessens , F , Clements , J , Collee , J M , Correa , M C , Couch , F J , Cox , A , Cunningham , J M , Cybulski , C , Czene , K , Daly , M B , defazio , A , Devilee , P , Diez , O , Gago-Dominguez , M , Donovan , J L , Doerk , T , Duell , E J , Dunning , A M , Dwek , M , Eccles , D M , Edlund , C K , Edwards , D R V , Ellberg , C , Evans , D G , Fasching , P A , Ferris , R L , Liloglou , T , Figueiredo , J C , Fletcher , O , Fortner , R T , Fostira , F , Franceschi , S , Friedman , E , Gallinger , S J , Ganz , P A , Garber , J , Garcia-Saenz , J A , Gayther , S A , Giles , G G , Godwin , A K , Goldberg , M S , Goldgar , D E , Goode , E L , Goodman , M T , Goodman , G , Grankvist , K , Greene , M H , Gronberg , H , Gronwald , J , Guenel , P , Hakansson , N , Hall , P , Hamann , U , Hamdy , F C , Hamilton , R J , Hampe , J , Haugen , A , Heitz , F , Herrero , R , Hillemanns , P , Hoffmeister , M , Hogdall , E , Hong , Y-C , Hopper , J L , Houlston , R , Hulick , P J , Hunter , D J , Huntsman , D G , Idos , G , Imyanitov , E N , Ingles , S A , Isaacs , C , Jakubowska , A , James , P , Jenkins , M A , Johansson , M , Johansson , M , John , E M , Joshi , A D , Kaneva , R , Karlan , B Y , Kelemen , L E , Kuhl , T , Khaw , K-T , Khusnutdinova , E , Kibel , A S , Kiemeney , L A , Kim , J , Kjaer , S K , Knight , J A , Kogevinas , M , Kote-Jarai , Z , Koutros , S , Kristensen , V N , Kupryjanczyk , J , Lacko , M , Lam , S , Lambrechts , D , Landi , M T , Lazarus , P , Le , N D , Lee , E , Lejbkowicz , F , Lenz , H-J , Leslie , G , Lessel , D , Lester , J , Levine , D A , Li , L , Li , C I , Lindblom , A , Lindor , N M , Liu , G , Loupakis , F , Lubinski , J , Maehle , L , Maier , C , Mannermaa , A , Le Marchand , L , Margolin , S , May , T , McGuffog , L , Meindl , A , Middha , P , Miller , A , Milne , R L , MacInnis , R J , Modugno , F , Montagna , M , Moreno , V , Moysich , K B , Mucci , L , Muir , K , Mulligan , A M , Nathanson , K L , Neal , D E , Ness , A R , Neuhausen , S L , Nevanlinna , H , Newcomb , P A , Newcomb , L F , Nielsen , F C , Nikitina-Zake , L , Nordestgaard , B G , Nussbaum , R L , Offit , K , Olah , E , Al Olama , A A , Olopade , O I , Olshan , A F , Olsson , H , Osorio , A , Pandha , H , Park , J Y , Pashayan , N , Parsons , M T , Pejovic , T , Penney , K L , Peters , W H M , Phelan , C M , Phipps , A I , Plaseska-Karanfilska , D , Pring , M , Prokofyeva , D , Radice , P , Stefansson , K , Ramus , S J , Raskin , L , Rennert , G , Rennert , H S , van Rensburg , E J , Riggan , M J , Risch , H A , Risch , A , Roobol , M J , Rosenstein , B S , Rossing , M A , De Ruyck , K , Saloustros , E , Sandler , D P , Sawyer , E J , Schabath , M B , Schleutker , J , Schmidt , M K , Setiawan , V W , Shen , H , Siegel , E M , Sieh , W , Singer , C F , Slattery , M L , Sorensen , K D , Southey , M C , Spurdle , A B , Stanford , J L , Stevens , V L , Stintzing , S , Stone , J , Sundfeldt , K , Sutphen , R , Swerdlow , A J , Tajara , E H , Tangen , C M , Tardon , A , Taylor , J A , Teare , M D , Teixeira , M R , Terry , M B , Terry , K L , Thibodeau , S N , Thomassen , M , Bjorge , L , Tischkowitz , M , Toland , A E , Torres , D , Townsend , P A , Travis , R C , Tung , N , Tworoger , S S , Ulrich , C M , Usmani , N , Vachon , C M , Van Nieuwenhuysen , E , Vega , A , Aguado-Barrera , M E , Wang , Q , Webb , P M , Weinberg , C R , Weinstein , S , Weissler , M C , Weitzel , J N , West , C M L , White , E , Whittemore , A S , Wichmann , H-E , Wiklund , F , Winqvist , R , Wolk , A , Woll , P , Woods , M , Wu , A H , Wu , X , Yannoukakos , D , Zheng , W , Zienolddiny , S , Ziogas , A , Zorn , K K , Lane , J M , Saxena , R , Thomas , D , Hung , R J , Diergaarde , B , Mckay , J , Peters , U , Hsu , L , Garcia-Closas , M , Eeles , R A , Chenevix-Trench , G , Brennan , P J , Haiman , C A , Simard , J , Easton , D F , Gruber , S B , Pharoah , P D P , Price , A L , Pasaniuc , B , Amos , C I , Kraft , P & Lindstrom , S 2019 , ' Shared heritability and functional enrichment across six solid cancers ' , Nature Communications , vol. 10 , 431 . https://doi.org/10.1038/s41467-018-08054-4Test; 85060528251; 47d3853b-ca40-4786-bc36-d116e27381fa; http://hdl.handle.net/10138/300017Test; 000456696700007 |
| الإتاحة: | http://hdl.handle.net/10138/300017Test |
| حقوق: | cc_by ; openAccess ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.6B037BE1 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |