Genetic variation in XRCC1, sun exposure, and risk of skin cancer
| العنوان: | Genetic variation in XRCC1, sun exposure, and risk of skin cancer |
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| المؤلفون: | Jiali Han, Graham A. Colditz, David J. Hunter, Susan E. Hankinson |
| المصدر: | British Journal of Cancer |
| بيانات النشر: | Nature Publishing Group, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Oncology, Adult, Cancer Research, medicine.medical_specialty, XRCC1, Skin Neoplasms, DNA Repair, Genotype, Sunburn, Biology, Polymerase Chain Reaction, Polymorphism, Single Nucleotide, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Basal cell carcinoma, Genetic Predisposition to Disease, Family history, 030304 developmental biology, Aged, Genetics, 0303 health sciences, Cocarcinogenesis, integumentary system, skin cancer, Melanoma, Haplotype, Case-control study, Genetic Variation, Genetics and Genomics, Middle Aged, medicine.disease, 3. Good health, DNA-Binding Proteins, X-ray Repair Cross Complementing Protein 1, Haplotypes, 030220 oncology & carcinogenesis, Case-Control Studies, Female, sunlight, Skin cancer |
| الوصف: | The XRCC1 gene is involved in the base excision repair pathway. We assessed the associations of polymorphisms and haplotypes in XRCC1 with skin cancer risk in a nested case–control study within the Nurses' Health Study (219 melanoma, 286 squamous cell carcinoma (SCC) and 300 basal cell carcinoma (BCC), and 873 controls). We genotyped four haplotype-tagging single-nucleotide polymorphisms (Arg194Trp, C26602T, Arg399Gln, and Gln632Gln). There was no significant difference in frequency distribution between cases and controls for any of the five inferred common haplotypes. We observed that the 399Gln allele was inversely associated with SCC risk. This inverse association was only seen among those who had five or more lifetime sunburns, those with a family history of skin cancer, and those in the highest tertile of cumulative sun exposure in a bathing suit, but not among those with low risk defined by these risk factors. We also observed a significant association of the carriage of 194Trp allele with increased SCC risk, which was modified by family history of skin cancer. These two polymorphisms were not associated with BCC or melanoma risk. Our data suggest that the Arg194Trp and Arg399Gln polymorphisms may be differently associated with skin cancer risk according to exposure dose and skin cancer type. |
| اللغة: | English |
| تدمد: | 1532-1827 0007-0920 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0f71d469c408108a1ac74d59a146e22Test http://europepmc.org/articles/PMC2409924Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0f71d469c408108a1ac74d59a146e22 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15321827 00070920 |
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