دورية أكاديمية
Group-level stability but individual variability of neurocognitive status after awake resections of right frontal IDH-mutated glioma
| العنوان: | Group-level stability but individual variability of neurocognitive status after awake resections of right frontal IDH-mutated glioma |
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| المؤلفون: | Barberis, Marion, Poisson, Isabelle, Facque, Valentine, Letrange, Sophie, Prevost-Tarabon, Cécile, Houdart, Emmanuel, Froelich, Sébastien, Levy, Richard, Mandonnet, Emmanuel |
| المساهمون: | Service de neurochirurgie AP-HP Hôpital Lariboisière, Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Institut du Cerveau = Paris Brain Institute (ICM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Hôpital Lariboisière-Fernand-Widal APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP) |
| المصدر: | ISSN: 2045-2322. |
| بيانات النشر: | HAL CCSD Nature Publishing Group |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Adult, Brain Mapping / methods, Brain Neoplasms / genetics, Brain Neoplasms / pathology, Brain Neoplasms / surgery, Glioma / genetics, Glioma / pathology, Glioma / surgery, Humans, Retrospective Studies, Wakefulness, [SDV.CAN]Life Sciences [q-bio]/Cancer, [SDV.MHEP.CHI]Life Sciences [q-bio]/Human health and pathology/Surgery, [SDV.NEU.SC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Cognitive Sciences |
| الوصف: | International audience ; Awake surgery for low-grade gliomas is currently considered the best procedure to improve the extent of resection and guarantee a "worth living life" for patients, meaning avoiding not only motor but also cognitive deficits. However, tumors located in the right hemisphere, especially in the right frontal lobe, are still rarely operated on in awake condition; one of the reasons possibly being that there is little information in the literature describing the rates and nature of long-lasting neuropsychological deficits following resection of right frontal glioma. To investigate long-term cognitive deficits after awake surgery in right frontal IDH-mutated glioma. We retrospectively analyzed a consecutive series of awake surgical resections between 2012 and 2020 for right frontal IDH-mutated glioma. We studied the patients' subjective complaints and objective neuropsychological evaluations, both before and after surgery. Our results were then put in perspective with the literature. Twenty surgical cases (including 5 cases of redo surgery) in eighteen patients (medium age: 42.5 [range 26–58]) were included in the study. The median preoperative volume was 37 cc; WHO grading was II, III and IV in 70%, 20%, and 10% of cases, respectively. Preoperatively, few patients had related subjective cognitive or behavioral impairment, while evaluations revealed mild deficits in 45% of cases, most often concerning executive functions, attention, working memory and speed processing. Immediate postoperative evaluations showed severe deficits of executive functions in 75% of cases but also attentional deficits (65%), spatial neglect (60%) and behavioral disturbances (apathy, aprosodia/amimia, emotional sensitivity, anosognosia). Four months after surgery, although psychometric z-scores were unchanged at the group level, individual evaluations showed a slight decrease of performance in 9/20 cases for at least one of the following domains: executive functions, speed processing, attention, semantic cognition, ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/35413966; hal-04456881; https://hal.science/hal-04456881Test; https://hal.science/hal-04456881/documentTest; https://hal.science/hal-04456881/file/s41598-022-08702-2.pdfTest; PUBMED: 35413966; PUBMEDCENTRAL: PMC9005659 |
| DOI: | 10.1038/s41598-022-08702-2 |
| الإتاحة: | https://doi.org/10.1038/s41598-022-08702-2Test https://hal.science/hal-04456881Test https://hal.science/hal-04456881/documentTest https://hal.science/hal-04456881/file/s41598-022-08702-2.pdfTest |
| حقوق: | http://creativecommons.org/licenses/byTest/ ; info:eu-repo/semantics/OpenAccess |
| رقم الانضمام: | edsbas.1A52CCFA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-022-08702-2 |
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