دورية أكاديمية
ATP-citrate lyase promotes axonal transport across species.
| العنوان: | ATP-citrate lyase promotes axonal transport across species. |
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| المؤلفون: | Even, Aviel, Morelli, Giovanni, Turchetto, Silvia, Shilian, Michal, Le Bail, Romain, Laguesse, Sophie, Krusy, Nathalie, Brisker, Ariel, Brandis, Alexander, Inbar, Shani, Chariot, Alain, Saudou, Frédéric, Dietrich, Paula, Dragatsis, Ioannis, Brone, Bert, Broix, Loïc, Rigo, Jean-Michel, Weil, Miguel, Nguyen, Laurent |
| المصدر: | Nature Communications, 12 (1), 5878 (2021) |
| بيانات النشر: | Nature Publishing Group, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | ATP Citrate (pro-S)-Lyase/genetics/metabolism, Acetyl Coenzyme A/metabolism, Acetylation, Acetyltransferases/genetics, Animals, Axonal Transport/genetics/physiology, Drosophila melanogaster, Dysautonomia, Familial/metabolism, Female, Fibroblasts/metabolism, Humans, Larva, Male, Mice, Microtubules/metabolism, Protein Processing, Post-Translational, Tubulin/metabolism, Human health sciences, Neurology, Sciences de la santé humaine, Neurologie |
| الوصف: | Microtubule (MT)-based transport is an evolutionary conserved process finely tuned by posttranslational modifications. Among them, α-tubulin acetylation, primarily catalyzed by a vesicular pool of α-tubulin N-acetyltransferase 1 (Atat1), promotes the recruitment and processivity of molecular motors along MT tracks. However, the mechanism that controls Atat1 activity remains poorly understood. Here, we show that ATP-citrate lyase (Acly) is enriched in vesicles and provide Acetyl-Coenzyme-A (Acetyl-CoA) to Atat1. In addition, we showed that Acly expression is reduced upon loss of Elongator activity, further connecting Elongator to Atat1 in a pathway regulating α-tubulin acetylation and MT-dependent transport in projection neurons, across species. Remarkably, comparable defects occur in fibroblasts from Familial Dysautonomia (FD) patients bearing an autosomal recessive mutation in the gene coding for the Elongator subunit ELP1. Our data may thus shine light on the pathophysiological mechanisms underlying FD. |
| نوع الوثيقة: | journal article http://purl.org/coar/resource_type/c_6501Test article peer reviewed |
| اللغة: | English |
| العلاقة: | urn:issn:2041-1723 |
| DOI: | 10.1038/s41467-021-25786-y |
| الوصول الحر: | https://orbi.uliege.be/handle/2268/264692Test |
| حقوق: | open access http://purl.org/coar/access_right/c_abf2Test info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsorb.264692 |
| قاعدة البيانات: | ORBi |
| DOI: | 10.1038/s41467-021-25786-y |
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