Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration
| العنوان: | Toll-like receptor 4 and MAIR-II/CLM-4/LMIR2 immunoreceptor regulate VLA-4-mediated inflammatory monocyte migration |
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| المؤلفون: | Kazumasa Kanemaru, Kazuko Shibuya, Akira Shibuya, Naoya Totsuka, Kouta Niizuma, Chigusa Nakahasi-Oda, Yun Gi Kim, Satoko Tahara-Hanaoka, Kei Nagai, Masayuki Miyasaka, Eiji Umemoto, Shin-ichiro Honda |
| المصدر: | Nature Communications |
| بيانات النشر: | Nature Pub. Group, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Lipopolysaccharides, Male, General Physics and Astronomy, Inflammatory monocyte, Biology, Integrin alpha4beta1, Peritonitis, General Biochemistry, Genetics and Molecular Biology, Article, Monocytes, Mice, Cell Movement, Cell Adhesion, Animals, Receptors, Immunologic, Receptor, Cecum, Ligation, Inflammation, Mice, Knockout, Toll-like receptor, Mice, Inbred BALB C, Multidisciplinary, Receptors, Polymeric Immunoglobulin, VLA-4, General Chemistry, Mice, Inbred C57BL, Toll-Like Receptor 4, Disease Models, Animal, Immunology, Myeloid Differentiation Factor 88, Female, Signal Transduction |
| الوصف: | Inflammatory monocytes play an important role in host defense against infections. However, the regulatory mechanisms of transmigration into infected tissue are not yet completely understood. Here we show that mice deficient in MAIR-II (also called CLM-4 or LMIR2) are more susceptible to caecal ligation and puncture (CLP)-induced peritonitis than wild-type (WT) mice. Adoptive transfer of inflammatory monocytes from WT mice, but not from MAIR-II, TLR4 or MyD88-deficient mice, significantly improves survival of MAIR-II-deficient mice after CLP. Migration of inflammatory monocytes into the peritoneal cavity after CLP, which is dependent on VLA-4, is impaired in above mutant and FcRγ chain-deficient mice. Lipopolysaccharide stimulation induces association of MAIR-II with FcRγ chain and Syk, leading to enhancement of VLA-4-mediated adhesion to VCAM-1. These results indicate that activation of MAIR-II/FcRγ chain by TLR4/MyD88-mediated signalling is essential for the transmigration of inflammatory monocytes from the blood to sites of infection mediated by VLA-4. Inflammatory monocytes play an important role in host defense against infections. Here the authors provide insights into the mechanism behind the recruitment of inflammatory monocytes to sites of infection by demonstrating the involvement of Toll-like receptor 4 and MAIR-II immunoreceptors in this process. |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eb59867eb56d43700cf7596d2d392e9Test http://europepmc.org/articles/PMC4143930Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....8eb59867eb56d43700cf7596d2d392e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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