دورية أكاديمية
A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae
| العنوان: | A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae |
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| المؤلفون: | Ramirez, Jose Luis, de Almeida Oliveira, Giselle, Calvo, Eric, Dalli, Jesmond, Colas, Romain A., Serhan, Charles N., Ribeiro, Jose M., Barillas-Mury, Carolina |
| بيانات النشر: | Nature Pub. Group |
| سنة النشر: | 2015 |
| المجموعة: | Harvard University: DASH - Digital Access to Scholarship at Harvard |
| الوصف: | Exposure of Anopheles gambiae mosquitoes to Plasmodium infection enhances the ability of their immune system to respond to subsequent infections. However, the molecular mechanism that allows the insect innate immune system to ‘remember' a previous encounter with a pathogen has not been established. Challenged mosquitoes constitutively release a soluble haemocyte differentiation factor into their haemolymph that, when transferred into Naive mosquitoes, also induces priming. Here we show that this factor consists of a Lipoxin/Lipocalin complex. We demonstrate that innate immune priming in mosquitoes involves a persistent increase in expression of Evokin (a lipid carrier of the lipocalin family), and in their ability to convert arachidonic acid to lipoxins, predominantly Lipoxin A4. Plasmodium ookinete midgut invasion triggers immune priming by inducing the release of a mosquito lipoxin/lipocalin complex. ; Version of Record |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542143/pdfTest/; Nature Communications; Ramirez, Jose Luis, Giselle de Almeida Oliveira, Eric Calvo, Jesmond Dalli, Romain A. Colas, Charles N. Serhan, Jose M. Ribeiro, and Carolina Barillas-Mury. 2015. “A mosquito lipoxin/lipocalin complex mediates innate immune priming in Anopheles gambiae.” Nature Communications 6 (1): 7403. doi:10.1038/ncomms8403. http://dx.doi.org/10.1038/ncomms8403Test.; http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856976Test |
| DOI: | 10.1038/ncomms8403 |
| الإتاحة: | https://doi.org/10.1038/ncomms8403Test http://nrs.harvard.edu/urn-3:HUL.InstRepos:22856976Test |
| رقم الانضمام: | edsbas.EA9A3281 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/ncomms8403 |