دورية أكاديمية
Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma
| العنوان: | Cross-species chromatin interactions drive transcriptional rewiring in Epstein-Barr virus-positive gastric adenocarcinoma |
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| المساهمون: | Atsushi Okabe, Kie Kyon Huang, Keisuke Matsusaka, Masaki Fukuyo, Manjie Xing 3, Xuewen Ong, Takayuki Hoshii, Genki Usui, Motoaki Seki, Yasunobu Mano, Bahityar Rahmutulla, Teru Kanda, Takayoshi Suzuki, Sun Young Rha, Tetsuo Ushiku, Masashi Fukayama, Patrick Tan, Atsushi Kaneda, Rha, Sun Young |
| بيانات النشر: | Nature Pub. Co. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adenocarcinoma / genetics, Adenocarcinoma / virology, Carcinogenesis / genetics, Cell Line, Tumor, Chromatin / genetics, Epigenomics / methods, Epstein-Barr Virus Infections / genetics, Herpesvirus 4, Human / genetics, Humans, Stomach Neoplasms / genetics, Stomach Neoplasms / virology, Transcription, Genetic / genetics |
| الوصف: | Epstein-Barr virus (EBV) is associated with several human malignancies including 8-10% of gastric cancers (GCs). Genome-wide analysis of 3D chromatin topologies across GC lines, primary tissue and normal gastric samples revealed chromatin domains specific to EBV-positive GC, exhibiting heterochromatin-to-euchromatin transitions and long-range human-viral interactions with non-integrated EBV episomes. EBV infection in vitro suffices to remodel chromatin topology and function at EBV-interacting host genomic loci, converting H3K9me3+ heterochromatin to H3K4me1+/H3K27ac+ bivalency and unleashing latent enhancers to engage and activate nearby GC-related genes (for example TGFBR2 and MZT1). Higher-order epigenotypes of EBV-positive GC thus signify a novel oncogenic paradigm whereby non-integrative viral genomes can directly alter host epigenetic landscapes ('enhancer infestation'), facilitating proto-oncogene activation and tumorigenesis. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1061-4036 1546-1718 32719515 |
| العلاقة: | NATURE GENETICS; J02294; OAK-2021-01127; https://ir.ymlib.yonsei.ac.kr/handle/22282913/182524Test; https://www.nature.com/articles/s41588-020-0665-7Test; T202004853; NATURE GENETICS, Vol.52(9) : 919-930, 2020-09 |
| DOI: | 10.1038/s41588-020-0665-7 |
| الإتاحة: | https://doi.org/10.1038/s41588-020-0665-7Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/182524Test https://www.nature.com/articles/s41588-020-0665-7Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.517CCA12 |
| قاعدة البيانات: | BASE |
| تدمد: | 10614036 15461718 32719515 |
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| DOI: | 10.1038/s41588-020-0665-7 |