دورية أكاديمية
Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis
| العنوان: | Single cell transcriptomic analyses implicate an immunosuppressive tumor microenvironment in pancreatic cancer liver metastasis |
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| المؤلفون: | Shu Zhang, Wen Fang, Siqi Zhou, Dongming Zhu, Ruidong Chen, Xin Gao, Zhuojin Li, Yao Fu, Yixuan Zhang, Fa Yang, Jing Zhao, Hao Wu, Pin Wang, Yonghua Shen, Shanshan Shen, Guifang Xu, Lei Wang, Chao Yan, Xiaoping Zou, Dijun Chen, Ying Lv |
| المصدر: | Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023) |
| بيانات النشر: | Nature Portfolio, 2023. |
| سنة النشر: | 2023 |
| المجموعة: | LCC:Science |
| مصطلحات موضوعية: | Science |
| الوصف: | Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly metastatic disease refractory to all targeted and immune therapies. However, our understanding of PDAC microenvironment especially the metastatic microenvironment is very limited partly due to the inaccessibility to metastatic tumor tissues. Here, we present the single-cell transcriptomic landscape of synchronously resected PDAC primary tumors and matched liver metastases. We perform comparative analysis on both cellular composition and functional phenotype between primary and metastatic tumors. Tumor cells exhibit distinct transcriptomic profile in liver metastasis with clearly defined evolutionary routes from cancer cells in primary tumor. We also identify specific subtypes of stromal and immune cells critical to the formation of the pro-tumor microenvironment in metastatic lesions, including RGS5+ cancer-associated fibroblasts, CCL18+ lipid-associated macrophages, S100A8+ neutrophils and FOXP3+ regulatory T cells. Cellular interactome analysis further reveals that the lack of tumor-immune cell interaction in metastatic tissues contributes to the formation of the immunosuppressive microenvironment. Our study provides a comprehensive characterization of the transcriptional landscape of PDAC liver metastasis. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2041-1723 35486627 |
| العلاقة: | https://doaj.org/toc/2041-1723Test |
| DOI: | 10.1038/s41467-023-40727-7 |
| الوصول الحر: | https://doaj.org/article/ee8e05608bfa45eb9d5a8a35486627bdTest |
| رقم الانضمام: | edsdoj.8e05608bfa45eb9d5a8a35486627bd |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20411723 35486627 |
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| DOI: | 10.1038/s41467-023-40727-7 |