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High expression of tight junction protein 1 as a predictive biomarker for bladder cancer grade and staging

التفاصيل البيبلوغرافية
العنوان: High expression of tight junction protein 1 as a predictive biomarker for bladder cancer grade and staging
المؤلفون: Yi-Chen Lee, Kuo-Wang Tsai, Jia-Bin Liao, Wei-Ting Kuo, Yu-Chan Chang, Yi-Fang Yang
المصدر: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
بيانات النشر: Nature Portfolio, 2022.
سنة النشر: 2022
المجموعة: LCC:Medicine
LCC:Science
مصطلحات موضوعية: Medicine, Science
الوصف: Abstract Tight junction proteins 1–3 (TJP1–3) are components of tight junctions that can link transmembrane proteins to the actin cytoskeleton, and their incidence directly correlates to metastasis. However, the role of the TJP family in bladder cancer has not been adequately evaluated. In this study, we evaluated the genetic changes, mRNA and protein expressions of the target genes of the TJP family in bladder cancer patients using online database and immunohistochemistry, respectively. We found that TJP1 was amplified in bladder cancer tissue and that the protein expression levels were significantly associated with age (p = 0.03), grade (p = 0.007), and stage (p = 0.011). We also examined the correlation between TJP1 and other high-frequency mutation genes using TIMER. TJP1 mRNA levels were positively correlated with TTN and RYR3 mRNA levels in bladder cancer tissue. Taken together, TJP1 expression is associated with poor clinical outcomes in patients with bladder cancer and can be a useful predictive biomarker for bladder cancer staging.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2045-2322
العلاقة: https://doaj.org/toc/2045-2322Test
DOI: 10.1038/s41598-022-05631-y
الوصول الحر: https://doaj.org/article/a62538d7361942d5a10511c363979268Test
رقم الانضمام: edsdoj.62538d7361942d5a10511c363979268
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20452322
DOI:10.1038/s41598-022-05631-y