دورية أكاديمية
A systems immunology approach to investigate cytokine responses to viruses and bacteria and their association with disease
| العنوان: | A systems immunology approach to investigate cytokine responses to viruses and bacteria and their association with disease |
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| المؤلفون: | Lin, L, Curtin, JA, Regis, E, Hirsman, A, Howard, R, Tutino, M, Edwards, MR, Prosperi, M, Simpson, A, Rattray, M, Custovic, A, Johnston, SL |
| المصدر: | 14 ; 1 |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2022 |
| المجموعة: | Imperial College London: Spiral |
| الوصف: | Patterns of human immune responses to viruses and bacteria and how this impacts risk of infections or onset/exacerbation of chronic respiratory diseases are poorly understood. In a population-based birth cohort, we measured peripheral blood mononuclear cell responses (28 cytokines) to respiratory viruses and bacteria, Toll-like receptor ligands and phytohemagglutinin, in 307 children. Cytokine responses were highly variable with > 1000-fold differences between children. Machine learning revealed clear distinction between virus-associated and bacteria-associated stimuli. Cytokines clustered into three functional groups (anti-viral, pro-inflammatory and T-cell derived). To investigate mechanisms potentially explaining such variable responses, we investigated cytokine Quantitative Trait Loci (cQTLs) of IL-6 responses to bacteria and identified nine (eight novel) loci. Our integrative approach describing stimuli, cytokines and children as variables revealed robust immunologically and microbiologically plausible clustering, providing a framework for a greater understanding of host-responses to infection, including novel genetic associations with respiratory disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | Scientific Reports; http://hdl.handle.net/10044/1/103194Test |
| DOI: | 10.1038/s41598-022-16509-4 |
| الإتاحة: | https://doi.org/10.1038/s41598-022-16509-4Test http://hdl.handle.net/10044/1/103194Test |
| حقوق: | © The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0Test/. ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.4320F242 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-16509-4 |