دورية أكاديمية
Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel
| العنوان: | Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel |
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| المؤلفون: | Ahmed Dawood Mohammed, Zahraa Mohammed, Mary M. Roland, Ioulia Chatzistamou, Amy Jolly, Lillian M. Schoettmer, Mireya Arroyo, Khadija Kakar, Yuan Tian, Andrew Patterson, Mitzi Nagarkatti, Prakash Nagarkatti, Jason L. Kubinak |
| المصدر: | Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022) |
| بيانات النشر: | Nature Portfolio |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | Science |
| الوصف: | Mucosal antibodies maintain gut homeostasis, and may influence gut health through modulation of microbiota composition. Here the authors use a CD19-deficient mouse model with deficient B-cell immune responses to uncover an association between humoral immunodeficiency, dysbiosis, and perturbations to bile acid homeostasis in the gut in the context of glute-sensitive enteropathy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2041-1723 |
| العلاقة: | https://doi.org/10.1038/s41467-022-28126-wTest; https://doaj.org/toc/2041-1723Test; https://doaj.org/article/0bb27704fdb64e328106157fc1cce1e7Test |
| DOI: | 10.1038/s41467-022-28126-w |
| الإتاحة: | https://doi.org/10.1038/s41467-022-28126-wTest https://doaj.org/article/0bb27704fdb64e328106157fc1cce1e7Test |
| رقم الانضمام: | edsbas.2892E6B4 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20411723 |
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| DOI: | 10.1038/s41467-022-28126-w |