دورية أكاديمية

The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure

التفاصيل البيبلوغرافية
العنوان: The platelet receptor CLEC-2 blocks neutrophil mediated hepatic recovery in acetaminophen induced acute liver failure
المؤلفون: Abhishek Chauhan, Lozan Sheriff, Mohammed T. Hussain, Gwilym J. Webb, Daniel A. Patten, Emma L. Shepherd, Robert Shaw, Christopher J. Weston, Debashis Haldar, Samuel Bourke, Rajan Bhandari, Stephanie Watson, David H. Adams, Steve P. Watson, Patricia F. Lalor
المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
بيانات النشر: Nature Portfolio, 2020.
سنة النشر: 2020
المجموعة: LCC:Science
مصطلحات موضوعية: Science
الوصف: The molecular mechanisms that drive irreversible acute liver failure remain poorly characterized. Here, the authors show that the recently discovered platelet receptor CLEC-2 (C-type lectin-like receptor) perpetuates and worsens liver damage during acute liver injury by blocking restorative neutrophil driven inflammation.
نوع الوثيقة: article
وصف الملف: electronic resource
اللغة: English
تدمد: 2041-1723
العلاقة: https://doaj.org/toc/2041-1723Test
DOI: 10.1038/s41467-020-15584-3
الوصول الحر: https://doaj.org/article/a6f8dbdcb34b42c0a82ada447cf8eac9Test
رقم الانضمام: edsdoj.6f8dbdcb34b42c0a82ada447cf8eac9
قاعدة البيانات: Directory of Open Access Journals
الوصف
تدمد:20411723
DOI:10.1038/s41467-020-15584-3