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1دورية أكاديمية
المؤلفون: Luciana de Araújo Pimenta, Evandro L. Duarte, Gabriel S. Vignoli Muniz, Kerly Fernanda Mesquita Pasqualoto, Marcos Roberto de Mattos Fontes, M. Teresa Lamy, Sandra Coccuzzo Sampaio
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-17 (2021)
الوصف: The important pharmacological actions of Crotoxin (CTX) on macrophages, the main toxin in the venom of Crotalus durissus terrificus, and its important participation in the control of different pathophysiological processes, have been demonstrated. The biological activities performed by macrophages are related to signaling mediated by receptors expressed on the membrane surface of these cells or opening and closing of ion channels, generation of membrane curvature and pore formation. In the present work, the interaction of the CTX complex with the cell membrane of macrophages is studied, both using biological cells and synthetic lipid membranes to monitor structural alterations induced by the protein. Here we show that CTX can penetrate THP-1 cells and induce pores only in anionic lipid model membranes, suggesting that a possible access pathway for CTX to the cell is via lipids with anionic polar heads. Considering that the selectivity of the lipid composition varies in different tissues and organs of the human body, the thermostructural studies presented here are extremely important to open new investigations on the biological activities of CTX in different biological systems.
العلاقة: https://doi.org/10.1038/s41598-021-02552-0Test; https://doaj.org/toc/2045-2322Test; https://doaj.org/article/03e95d123a8a4cfc8d436f3c84350d12Test
الإتاحة: https://doi.org/10.1038/s41598-021-02552-0Test
https://doaj.org/article/03e95d123a8a4cfc8d436f3c84350d12Test -
2دورية أكاديمية
المؤلفون: Sant-Rayn Pasricha, Pei Jin Lim, Tiago L. Duarte, Carla Casu, Dorenda Oosterhuis, Katarzyna Mleczko-Sanecka, Maria Suciu, Ana Rita Da Silva, Kinda Al-Hourani, João Arezes, Kirsty McHugh, Sarah Gooding, Joe N. Frost, Katherine Wray, Ana Santos, Graça Porto, Emmanouela Repapi, Nicki Gray, Simon J. Draper, Neil Ashley, Elizabeth Soilleux, Peter Olinga, Martina U. Muckenthaler, Jim R. Hughes, Stefano Rivella, Thomas A. Milne, Andrew E. Armitage, Hal Drakesmith
المصدر: Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
مصطلحات موضوعية: Science
الوصف: Hepcidin controls systemic iron levels by inhibiting intestinal iron absorption and iron recycling. Here, Pasricha et al. demonstrate that the hepcidin-chromatin locus displays HDAC3-mediated reversible epigenetic modifications during both erythropoiesis and iron deficiency.
العلاقة: https://doi.org/10.1038/s41467-017-00500-zTest; https://doaj.org/toc/2041-1723Test; https://doaj.org/article/15032712babd4934b8cf9987f86cc0baTest
الإتاحة: https://doi.org/10.1038/s41467-017-00500-zTest
https://doaj.org/article/15032712babd4934b8cf9987f86cc0baTest