دورية أكاديمية
Genome-wide association study identifies susceptibility loci for acute myeloid leukemia
| العنوان: | Genome-wide association study identifies susceptibility loci for acute myeloid leukemia |
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| المؤلفون: | Lin, Wei-Yu, Fordham, Sarah E, Hungate, Eric, Sunter, Nicola J, Elstob, Claire, Xu, Yaobo, Park, Catherine, Quante, Anne, Strauch, Konstantin, Gieger, Christian, Skol, Andrew, Rahman, Thahira, Sucheston-Campbell, Lara, Wang, Junke, Hahn, Theresa, Clay-Gilmour, Alyssa I, Jones, Gail L, Marr, Helen J, Jackson, Graham H, Menne, Tobias, Collin, Mathew, Ivey, Adam, Hills, Robert K, Burnett, Alan K, Russell, Nigel H, Fitzgibbon, Jude, Larson, Richard A, Le Beau, Michelle M, Stock, Wendy, Heidenreich, Olaf, Alharbi, Abrar, Allsup, David J, Houlston, Richard S, Norden, Jean, Dickinson, Anne M, Douglas, Elisabeth, Lendrem, Clare, Daly, Ann K, Palm, Louise, Piechocki, Kim, Jeffries, Sally, Bornhäuser, Martin, Röllig, Christoph, Altmann, Heidi, Ruhnke, Leo, Kunadt, Desiree, Wagenführ, Lisa, Cordell, Heather J, Darlay, Rebecca, Andersen, Mette K, Fontana, Maria C, Martinelli, Giovanni, Marconi, Giovani, Sanz, Miguel A, Cervera, José, Gómez-Seguí, Inés, Cluzeau, Thomas, Moreilhon, Chimène, Raynaud, Sophie, Sill, Heinz, Voso, Maria Teresa, Lo-Coco, Francesco, Dombret, Hervé, Cheok, Meyling, Preudhomme, Claude, Gale, Rosemary E, Linch, David, Gaal-Wesinger, Julia, Masszi, Andras, Nowak, Daniel, Hofmann, Wolf-Karsten, Gilkes, Amanda, Porkka, Kimmo, Milosevic Feenstra, Jelena D, Kralovics, Robert, Grimwade, David, Meggendorfer, Manja, Haferlach, Torsten, Krizsán, Szilvia, Bödör, Csaba, Stölzel, Friedrich, Onel, Kenan, Allan, James M |
| المساهمون: | Lin, W, Fordham, Se, Hungate, E, Sunter, Nj, Elstob, C, Xu, Y, Park, C, Quante, A, Strauch, K, Gieger, C, Skol, A, Rahman, T, Sucheston-Campbell, L, Wang, J, Hahn, T, Clay-Gilmour, Ai, Jones, Gl, Marr, Hj, Jackson, Gh, Menne, T, Collin, M, Ivey, A, Hills, Rk, Burnett, Ak, Russell, Nh, Fitzgibbon, J, Larson, Ra, Le Beau, Mm, Stock, W, Heidenreich, O, Alharbi, A, Allsup, Dj, Houlston, R, Norden, J, Dickinson, Am, Douglas, E, Lendrem, C, Daly, Ak, Palm, L, Piechocki, K, Jeffries, S, Bornhäuser, M, Röllig, C, Altmann, H, Ruhnke, L, Kunadt, D, Wagenführ, L, Cordell, Hj, Darlay, R, Andersen, Mk, Fontana, Mc, Martinelli, G, Marconi, G, Sanz, Ma, Cervera, J, Gómez-Seguí, I, Cluzeau, T, Moreilhon, C, Raynaud, S, Sill, H, Voso, Mt, Lo-Coco, F, Dombret, H, Cheok, M, Preudhomme, C, Gale, Re, Linch, D, Gaal-Wesinger, J, Masszi, A, Nowak, D, Hofmann, W, Gilkes, A, Porkka, K, Milosevic Feenstra, Jd, Kralovics, R, Grimwade, D, Meggendorfer, M, Haferlach, T, Krizsán, S, Bödör, C, Stölzel, F, Onel, K, Allan, Jm |
| بيانات النشر: | NATURE PORTFOLIO |
| سنة النشر: | 2021 |
| المجموعة: | Universitá degli Studi di Roma "Tor Vergata": ART - Archivio Istituzionale della Ricerca |
| مصطلحات موضوعية: | Aldehyde Reductase, Case-Control Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, HLA Antigens, Humans, Leukemia, Myeloid, Acute, Middle Aged, Reproducibility of Results, Whites, Polymorphism, Single Nucleotide, Settore MED/15 - MALATTIE DEL SANGUE |
| الوصف: | Acute myeloid leukemia (AML) is a hematological malignancy with an undefined heritable risk. Here we perform a meta-analysis of three genome-wide association studies, with replication in a fourth study, incorporating a total of 4018 AML cases and 10488 controls. We identify a genome-wide significant risk locus for AML at 11q13.2 (rs4930561; P = 2.15 x 10(-8); KMT5B). We also identify a genome-wide significant risk locus for the cytogenetically normal AML sub-group (N = 1287) at 6p21.32 (rs3916765; P = 1.51 x 10(-10); HLA). Our results inform on AML etiology and identify putative functional genes operating in histone methylation (KMT5B) and immune function (HLA).Genome wide association studies in cancer are used to understand the heritable genetic contribution to disease risk. Here, the authors perform a genome wide association study in European patients with acute myeloid leukemia and identify loci associated with risk of developing the disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/34716350; info:eu-repo/semantics/altIdentifier/wos/WOS:000712910500011; volume:12; issue:1; firstpage:6233; journal:NATURE COMMUNICATIONS; http://hdl.handle.net/2108/283234Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85118442520 |
| DOI: | 10.1038/s41467-021-26551-x |
| الإتاحة: | https://doi.org/10.1038/s41467-021-26551-xTest http://hdl.handle.net/2108/283234Test |
| رقم الانضمام: | edsbas.B9F64724 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-021-26551-x |
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