دورية أكاديمية
Ferroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma
| العنوان: | Ferroptosis-related lncRNA signature predicts the prognosis and immune microenvironment of hepatocellular carcinoma |
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| المؤلفون: | Chongkai Fang, Silin Liu, Kunliang Feng, Chaoyuan Huang, Ying Zhang, Jinan Wang, Hongtong Lin, Junyan Wang, Chong Zhong |
| المصدر: | Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022) |
| بيانات النشر: | Nature Portfolio, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Medicine LCC:Science |
| مصطلحات موضوعية: | Medicine, Science |
| الوصف: | Abstract This study aimed to construct a ferroptosis-related lncRNA signature to probe the prognosis and immune infiltration of HCC patients. The Cancer Genome Atlas (TCGA) database was randomly divided into two parts, with two-thirds training and one-third testing sets. Univariate, multivariate, and least absolute selection operator (LASSO) Cox regression analyses were performed to establish a ferroptosis-related lncRNA signature. The prognostic signature was constructed by 6 ferroptosis-related lncRNAs (PCAT6, MKLN1-AS, POLH-AS1, LINC00942, AL031985.3, LINC00942) shows a promising clinical prediction value in patients with HCC. Patients with high-risk score indicated a poorer prognosis than patients with low-risk score were shown in the training set (p |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | https://doaj.org/toc/2045-2322Test |
| DOI: | 10.1038/s41598-022-10508-1 |
| الوصول الحر: | https://doaj.org/article/1fef080e5d7e4515b6be4bb6aee86260Test |
| رقم الانضمام: | edsdoj.1fef080e5d7e4515b6be4bb6aee86260 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-022-10508-1 |