The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype
| العنوان: | The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype |
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| المؤلفون: | Frederic S Arendrup, Jens S. Andersen, Marta Montes, Anders H. Lund, Sarunas Tumas, Lea M. Harder, Anders Jacobsen Skanderup, Neha Rohatgi, Bettina Mentz, Michal Lubas |
| المصدر: | Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021) Nature Communications Montes, M, Lubas, M, Arendrup, F S, Mentz, B, Rohatgi, N, Tumas, S, Harder, L M, Skanderup, A J, Andersen, J S & Lund, A H 2021, ' The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype ', Nature Communications, vol. 12, no. 1, 2459 . https://doi.org/10.1038/s41467-021-22746-4Test Montes, M, Lubas, M, Arendrup, F S, Mentz, B, Rohatgi, N, Tumas, S, Harder, L M, Skanderup, A J, Andersen, J S & Lund, A H 2021, ' The long non-coding RNA MIR31HG regulates the senescence associated secretory phenotype ', Nature Communications, vol. 12, no. 1, 2459, pp. 1-17 . https://doi.org/10.1038/s41467-021-22746-4Test |
| بيانات النشر: | Nature Portfolio, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Translation, Aging, General Physics and Astronomy, 0302 clinical medicine, Transcription (biology), Neoplasms, Aging/genetics, Phosphorylation, Cellular Senescence, Multidisciplinary, Kinase, Cell Transformation, Neoplastic/genetics, Cyclin-Dependent Kinase Inhibitor p16/biosynthesis, Translation (biology), Neoplasms/genetics, Cell biology, Gene Expression Regulation, Neoplastic, Proto-Oncogene Proteins B-raf/metabolism, Cell Transformation, Neoplastic, Cellular Senescence/genetics, 030220 oncology & carcinogenesis, RNA, Long Noncoding, Proto-Oncogene Proteins B-raf, Senescence, Science, Repressor, Biology, Ribosomal Protein S6 Kinases, 90-kDa, Article, General Biochemistry, Genetics and Molecular Biology, Cell Line, Cell Proliferation/genetics, 03 medical and health sciences, Paracrine signalling, Humans, Secretion, RNA, Long Noncoding/genetics, Cyclin-Dependent Kinase Inhibitor p16, Cell Proliferation, fungi, Oncogenes, General Chemistry, Gene Expression Regulation, Neoplastic/genetics, 030104 developmental biology, Ribosomal Protein S6 Kinases, 90-kDa/metabolism, Long non-coding RNAs, Y-Box-Binding Protein 1, Y-Box-Binding Protein 1/metabolism |
| الوصف: | Oncogene-induced senescence provides a barrier against malignant transformation. However, it can also promote cancer through the secretion of a plethora of factors released by senescent cells, called the senescence associated secretory phenotype (SASP). We have previously shown that in proliferating cells, nuclear lncRNA MIR31HG inhibits p16/CDKN2A expression through interaction with polycomb repressor complexes and that during BRAF-induced senescence, MIR31HG is overexpressed and translocates to the cytoplasm. Here, we show that MIR31HG regulates the expression and secretion of a subset of SASP components during BRAF-induced senescence. The SASP secreted from senescent cells depleted for MIR31HG fails to induce paracrine invasion without affecting the growth inhibitory effect. Mechanistically, MIR31HG interacts with YBX1 facilitating its phosphorylation at serine 102 (p-YBX1S102) by the kinase RSK. p-YBX1S102 induces IL1A translation which activates the transcription of the other SASP mRNAs. Our results suggest a dual role for MIR31HG in senescence depending on its localization and points to the lncRNA as a potential therapeutic target in the treatment of senescence-related pathologies. Senescence-associated secretory phenotype (SASP) involves secretion of factors such as pro-inflammatory cytokines. Here the authors show that MIR31HG regulates the expression and secretion of a subset of SASP components that induce paracrine invasion, through interaction with YBX1 and induction of IL1A translation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::546e726c91808867332c4f90a83cb157Test https://doaj.org/article/8da6f54bfa9d4666b2534cafaba5a56aTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....546e726c91808867332c4f90a83cb157 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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