دورية أكاديمية
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
| العنوان: | E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium. |
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| المؤلفون: | Horne, HN, Oh, H, Sherman, ME, Palakal, M, Hewitt, SM, Schmidt, MK, Milne, RL, Hardisson, D, Benitez, J, Blomqvist, C, Bolla, MK, Brenner, H, Chang-Claude, J, Cora, R, Couch, FJ, Cuk, K, Devilee, P, Easton, DF, Eccles, DM, Eilber, U, Hartikainen, JM, Heikkilä, P, Holleczek, B, Hooning, MJ, Jones, M, Keeman, R, Mannermaa, A, Martens, JWM, Muranen, TA, Nevanlinna, H, Olson, JE, Orr, N, Perez, JIA, Pharoah, PDP, Ruddy, KJ, Saum, K-U, Schoemaker, MJ, Seynaeve, C, Sironen, R, Smit, VTHBM, Swerdlow, AJ, Tengström, M, Thomas, AS, Timmermans, AM, Tollenaar, RAEM, Troester, MA, van Asperen, CJ, van Deurzen, CHM, Van Leeuwen, FF, Van't Veer, LJ, García-Closas, M, Figueroa, JD |
| المساهمون: | Jones, Michael, Schoemaker, Minouk, Swerdlow, Anthony |
| بيانات النشر: | NATURE PORTFOLIO |
| سنة النشر: | 2018 |
| المجموعة: | The Institute of Cancer Research (ICR): Publications Repository |
| مصطلحات موضوعية: | Humans, Breast Neoplasms, Receptor, erbB-2, Cadherins, Receptors, Estrogen, Progesterone, Prognosis, Proportional Hazards Models, Odds Ratio, Risk Factors, Case-Control Studies, Gene Expression, Adult, Aged, Middle Aged, Female, Biomarkers, Tumor |
| الوصف: | E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry expression using tissue microarrays of 5,933 female invasive breast cancers from 12 studies from the Breast Cancer Consortium. H-scores were calculated and case-case odds ratios (OR) and 95% confidence intervals (CIs) were estimated using logistic regression. Survival analyses were performed using Cox regression models. All analyses were stratified by estrogen receptor (ER) status and histologic subtype. E-cadherin low cases (N = 1191, 20%) were more frequently of lobular histology, low grade, >2 cm, and HER2-negative. Loss of E-cadherin expression (score < 100) was associated with menopausal hormone use among ER-positive tumors (ever compared to never users, OR = 1.24, 95% CI = 0.97-1.59), which was stronger when we evaluated complete loss of E-cadherin (i.e. H-score = 0), OR = 1.57, 95% CI = 1.06-2.33. Breast cancer specific mortality was unrelated to E-cadherin expression in multivariable models. E-cadherin low expression is associated with lobular histology, tumor characteristics and menopausal hormone use, with no evidence of an association with breast cancer specific survival. These data support loss of E-cadherin expression as an important marker of tumor subtypes. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | Electronic; ?; application/pdf |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | Scientific reports, 2018, 8 (1), pp. 6574 - ?; https://repository.icr.ac.uk/handle/internal/1674Test |
| DOI: | 10.1038/s41598-018-23733-4 |
| الإتاحة: | https://doi.org/10.1038/s41598-018-23733-4Test https://repository.icr.ac.uk/handle/internal/1674Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.F8E57704 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/s41598-018-23733-4 |