نتائج البحث

1

Chloride sensing by WNK1 regulates NLRP3 inflammasome activation and pyroptosis

المؤلفون: Emad S. Alnemri, Teresa Fernandes-Alnemri, Jian Xie, Victor L. J. Tybulewicz, Aura Enache, Robert Köchl, Lindsey Mayes-Hopfinger, Chou Long Huang

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Lipopolysaccharides, Male, Pyrrolidines, Inflammasomes, Neutrophils, Interleukin-1beta, General Physics and Astronomy, Inflammasome, 0302 clinical medicine, WNK Lysine-Deficient Protein Kinase 1, Conditional gene knockout, Multidisciplinary, integumentary system, Chemistry, Caspase 1, Pyroptosis, Imidazoles, Cell biology, 030220 oncology & carcinogenesis, Female, Intracellular, medicine.drug, Cell death, Science, Protein Serine-Threonine Kinases, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, Proinflammatory cytokine, 03 medical and health sciences, Chlorides, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Kinase activity, Monocytes and macrophages, Innate immune system, L-Lactate Dehydrogenase, Macrophages, General Chemistry, Immunity, Innate, Mice, Inbred C57BL, Tamoxifen, 030104 developmental biology, Potassium

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5f780841c38901b3d5be2b16ce4f2bdTest
https://doaj.org/article/e7b7e958ca504bdc89a48c00f18c7b6cTest

2

Restoration of the molecular clock is tumor suppressive in neuroblastoma

المؤلفون: Nagireddy Putluri, Eveline Barbieri, John Hicks, Karthik reddy kami reddy, Pavel Sumazin, Thomas P. Burris, Simone Di Giacomo, Baharan Fekry, Ling Tao, Bokai Zhu, Mario Capasso, Giorgio Milazzo, Giovanni Perini, Sanjeev A. Vasudevan, Myrthala Moreno-Smith, Kristin Eckel-Mahan, Mahmoud A. Mohammad, Roshan Borkar

المساهمون: Moreno-Smith M., Milazzo G., Tao L., Fekry B., Zhu B., Mohammad M.A., Di Giacomo S., Borkar R., Reddy K.R.K., Capasso M., Vasudevan S.A., Sumazin P., Hicks J., Putluri N., Perini G., Eckel-Mahan K., Burris T.P., Barbieri E., Moreno-Smith, M., Milazzo, G., Tao, L., Fekry, B., Zhu, B., Mohammad, M. A., Di Giacomo, S., Borkar, R., Reddy, K. R. K., Capasso, M., Vasudevan, S. A., Sumazin, P., Hicks, J., Putluri, N., Perini, G., Eckel-Mahan, K., Burris, T. P., Barbieri, E.

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Nature Communications
nature communications

مصطلحات موضوعية: 0301 basic medicine, General Physics and Astronomy, Stimulation, Antineoplastic Agent, Mice, Neuroblastoma, 0302 clinical medicine, MYCN, Promoter Regions, Genetic, Cancer, N-Myc Proto-Oncogene Protein, Multidisciplinary, Chemistry, ARNTL Transcription Factors, Nuclear Receptor Subfamily 1, Group F, Member 1, ARNTL Transcription Factor, 030220 oncology & carcinogenesis, Benzamides, Lipogenesis, Human, Agonist, Cell biology, tumor, medicine.drug_class, Cell Survival, Science, Repressor, Antineoplastic Agents, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Benzamide, Cell Line, Tumor, medicine, Oscillation (cell signaling), Animals, Humans, neoplasms, Activator (genetics), Animal, Lipogenesi, Promoter, General Chemistry, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Cancer research, RNA-seq

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6711e7910483d55e549b75273bcadacTest
https://doaj.org/article/36f78ce6f76041c49c8161f0733a70f4Test

3

Suppressor of cytokine signaling-1 mimetic peptides attenuate lymphocyte activation in the MRL/lpr mouse autoimmune model

المؤلفون: Laurence Morel, Teresa D Collins, Caleb Cornaby, Howard M. Johnson, Mohammed I. Haider, Antia E Veal, Zaynab Sidi Mohamed, Joseph Larkin, Amari Jones, Shiwangi Mishra, Tracoyia Roach, Jatin Sharma, Timothy B. Polk, Brandon Lam, Leilani Zeumer-Spataro

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

مصطلحات موضوعية: CD4-Positive T-Lymphocytes, 0301 basic medicine, Mice, Inbred MRL lpr, Lymphocyte, medicine.medical_treatment, Diseases, Pathogenesis, CD8-Positive T-Lymphocytes, T-Lymphocytes, Regulatory, 0302 clinical medicine, Biomimetics, Lupus Erythematosus, Systemic, Interferon gamma, Lymphocytes, B-Lymphocytes, Multidisciplinary, Molecular medicine, Chemistry, JAK-STAT signaling pathway, Forkhead Transcription Factors, STAT Transcription Factors, medicine.anatomical_structure, Cytokine, Cytokines, Medicine, medicine.drug, Cell biology, Science, Immunology, Spleen, Article, Autoimmune Diseases, Interferon-gamma, 03 medical and health sciences, Suppressor of Cytokine Signaling 1 Protein, Rheumatology, medicine, Animals, fas Receptor, Janus Kinases, Suppressor of cytokine signaling 1, Germinal center, 030104 developmental biology, Cancer research, Lymph Nodes, Peptides, CD8, 030215 immunology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c981d069951d9bd958d1d7c1600dfacTest
https://doaj.org/article/342a0706da1e4e82ad0f8fd96bbb0a38Test

4

STAT3 governs the HIF-1α response in IL-15 primed human NK cells

المؤلفون: Sonia Y. Velásquez, Holger A. Lindner, Jutta Schulte, Nina Kassner, Anna Coulibaly, Maria Vittoria Barbarossa

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Scientific Reports

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdf0cf122d5d40145123dfc033bfd789Test
https://doaj.org/article/241d538460a74c8eb2e876ba1dfab688Test

5

Compounds targeting OSBPL7 increase ABCA1-dependent cholesterol efflux preserving kidney function in two models of kidney disease

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Receptors, Steroid, THP-1 Cells, General Physics and Astronomy, 030204 cardiovascular system & hematology, Pharmacology, Kidney, chemistry.chemical_compound, 0302 clinical medicine, Diabetic Nephropathies, Organic Chemicals, Cells, Cultured, Mice, Knockout, Kidney diseases, Multidisciplinary, biology, Molecular Structure, Podocytes, Lipids, Proteinuria, Cholesterol, Nephrology, RNA Interference, lipids (amino acids, peptides, and proteins), Efflux, Oxysterol-binding protein, ATP Binding Cassette Transporter 1, Niacinamide, Mice, 129 Strain, Science, Article, General Biochemistry, Genetics and Molecular Biology, Nephropathy, 03 medical and health sciences, medicine, Animals, Humans, Drug discovery and development, Alport syndrome, business.industry, Kidney metabolism, Biological Transport, General Chemistry, medicine.disease, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, chemistry, ABCA1, biology.protein, business, Kidney disease

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::611e43c9d19f38f7c76f45238644438bTest
https://doaj.org/article/c5e4a9ac05ca4c609714e39b90c7084eTest

6

Regulation of Rac1 transcription by histone and DNA methylation in diabetic retinopathy

المؤلفون: Renu A. Kowluru, Rakesh Radhakrishnan, Ghulam Mohammad

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-10 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, DNA (Cytosine-5-)-Methyltransferase 1, rac1 GTP-Binding Protein, Transcription, Genetic, Science, Diseases, Models, Biological, Article, Histones, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, Transcription (biology), Histone methylation, Animals, Humans, Epigenetics, RNA, Messenger, Promoter Regions, Genetic, Multidisciplinary, Diabetic Retinopathy, biology, Chemistry, Retinal Vessels, Transfection, Methyltransferases, DNA Methylation, Cell biology, Mice, Inbred C57BL, Repressor Proteins, 030104 developmental biology, Histone, Glucose, Gene Expression Regulation, DNA methylation, Microvessels, biology.protein, DNMT1, 5-Methylcytosine, Medicine, Protein Processing, Post-Translational, 030217 neurology & neurosurgery, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::345355de19b46ada6e87985c9dfbfd23Test
https://doaj.org/article/ecd9541b00b64777b0106355a4ab418bTest

7

Collagen and elastic fibres in acute and chronic liver injury

المؤلفون: Andrew Hall, Prithi S. Bhathal, Alberto Quaglia, Tu Vinh Luong, Corina Cotoi, Jennifer Watkins

المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, Adult, Liver Cirrhosis, Male, Pathology, medicine.medical_specialty, Victoria blue, Cirrhosis, Science, Liver fibrosis, Article, Extracellular matrix, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Medical research, medicine, Humans, Liver diseases, Retrospective Studies, Multidisciplinary, biology, Chemistry, Liver Failure, Acute, medicine.disease, biology.organism_classification, Elastic Tissue, Immunohistochemistry, Elastin, Extracellular Matrix, Transplantation, Collagen, type I, alpha 1, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Hepatocyte, biology.protein, Hepatocytes, Medicine, Female, Collagen

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41398d334f36be95e1c8b85448f98e8eTest
https://doaj.org/article/66f92431e9684711a334667c8e4a59d0Test

8

Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels

المؤلفون: Roland H Stimson, Neil Henderson, Marc R. Dweck, Cécile Bénézech, Zoi Michalidou, Calum C. Bain, Stephen J. Jenkins, Prakash Ramachandran, Laura Denby, Lucy H. Jackson-Jones, Marlene Magalhaes, Jordan R. Portman, Pete Smith

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications
Magalhaes, M S, Smith, P, Portman, J, Jackson-Jones, L H, Bain, C C, Ramachandran, P, Michailidou, Z, Stimson, R H, Dweck, M R, Denby, L, Henderson, N C, Jenkins, S J & Benezech, C 2021, ' Role of Tim4 in the regulation of ABCA1+ adipose tissue macrophages and post-prandial cholesterol levels ', Nature Communications . https://doi.org/10.1038/s41467-021-24684-7Test

مصطلحات موضوعية: 0301 basic medicine, Vesicular Transport Proteins, General Physics and Astronomy, Adipose tissue, 030204 cardiovascular system & hematology, Mice, chemistry.chemical_compound, 0302 clinical medicine, High-density lipoprotein, Macrophage, education.field_of_study, Multidisciplinary, biology, digestive, oral, and skin physiology, Postprandial Period, Cholesterol, Adipose Tissue, lipids (amino acids, peptides, and proteins), Fat metabolism, ATP Binding Cassette Transporter 1, Transcriptional Activation, medicine.medical_specialty, Adipose tissue macrophages, Science, Population, Diet, High-Fat, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Internal medicine, medicine, Animals, Obesity, education, Monocytes and macrophages, Dyslipidaemias, Macrophages, Cholesterol, HDL, Membrane Proteins, Lipid metabolism, General Chemistry, Lipid Metabolism, 030104 developmental biology, Endocrinology, chemistry, ABCA1, biology.protein, Lysosomes

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11712ff8dd85c40f46ba080f7304e8b2Test
https://doaj.org/article/39a4cc25e8ac438eaf00455de7457431Test

9

Neutrophil-derived reactive oxygen species promote tumor colonization

المؤلفون: Rikard Holmdahl, Jianghong Zhong, Huqiao Luo, Qijing Li

المصدر: Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Communications Biology

مصطلحات موضوعية: 0301 basic medicine, Cell type, Neutrophils, QH301-705.5, Transgene, Interleukin-1beta, Mutant, Medicine (miscellaneous), Mice, Transgenic, Polymorphism, Single Nucleotide, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 0302 clinical medicine, Cell Line, Tumor, Neoplasms, Animals, Humans, Calgranulin A, Biology (General), Melanoma, Lung, Mice, Knockout, chemistry.chemical_classification, Reactive oxygen species, biology, Disease genetics, Macrophages, Wild type, NADPH Oxidases, Neutrophil cytosolic factor 1, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, 030104 developmental biology, chemistry, Cell culture, 030220 oncology & carcinogenesis, Cancer research, biology.protein, cardiovascular system, Antibody, Reactive Oxygen Species, General Agricultural and Biological Sciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4d865db73ab07b48c3268c7d373bcaTest
https://doaj.org/article/dcc015fbb2bc41d0aa67b18ff8fcbeacTest

10

Structure and mechanism of the human NHE1-CHP1 complex

المؤلفون: Xuejun C. Zhang, Annie Boucher, Dusik Kim, Yiwei Gao, Yanli Dong, Bin Li, Alina Ilie, John Orlowski, Yan Zhao

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Models, Molecular, Conformational change, Protein Conformation, Intracellular pH, Protein subunit, Science, General Physics and Astronomy, Heart failure, Plasma protein binding, Guanidines, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Protein structure, Membrane proteins, Humans, Sulfones, Binding site, Multidisciplinary, Binding Sites, Sodium-Hydrogen Exchanger 1, Cariporide, Calcium-Binding Proteins, Cryoelectron Microscopy, Biological Transport, General Chemistry, 030104 developmental biology, chemistry, Membrane protein, Multiprotein Complexes, Biophysics, Permeation and transport, Protein Multimerization, 030217 neurology & neurosurgery, Protein Binding

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc3fa43f261346f033edcd02f92efb23Test
https://doaj.org/article/3f4c24b1d2414fd2bb2b6bbd97155253Test

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