B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells
| العنوان: | B cell receptor ligation induces display of V-region peptides on MHC class II molecules to T cells |
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| المؤلفون: | Ludvig A. Munthe, Karl Schenck, Geir Åge Løset, Ramakrishna Prabhu Gopalakrishnan, Peter C. Huszthy, Johanne T. Jacobsen, Ole Audun Werner Haabeth, Ranveig Braathen, Bjarne Bogen, Anders Aune Tveita |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America |
| بيانات النشر: | National Academy of Sciences, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | CD4-Positive T-Lymphocytes, T-Lymphocytes, Cell, B-cell receptor, Naive B cell, Betennelse og immunsystem: Normal biologisk utvikling og funksjon, Receptors, Antigen, B-Cell, VDP::Midical sciences: 700::Basic medical, dental and veterinary sciences: 710::Medical immunology: 716, VDP::Medisinske fag: 700::Basale medisinske, odontologiske og veterinærmedisinske fag: 710::Medisinsk immunologi: 716, Autoimmune Diseases, Mice, Immunology and Inflammation, Antigen, medicine, Animals, idiotype-driven T–B collaboration, BCR ligation by antigen, B cell, Inflammatory and Immune System: Normal biological development and functioning, B-Lymphocytes, Mice, Inbred BALB C, MHC class II, Multidisciplinary, biology, Chemistry, Neuropeptides, Histocompatibility Antigens Class II, breakpoint cluster region, Germinal center, Biological Sciences, V-gene modified mouse model, Antibodies, Anti-Idiotypic, Cell biology, Disease Models, Animal, M315-like BCR, medicine.anatomical_structure, PNAS Plus, Immunoglobulin G, biology.protein, idiotypic peptide: MHCII |
| الوصف: | Significance B and T lymphocytes collaborate during immune responses to antigens. B cells use membrane-bound antibody as part of their antigen receptor while T cells use a different receptor that recognizes antigen fragments bound to MHC molecules. We show here that T cells can recognize the variable parts of the B cell receptor when these are presented on MHC molecules. A prerequisite for such receptor cross-talk is that the B cell receptor binds antigen. The cross-talk results in collaboration between B and T cells and production of antibodies directed against the antigen. The findings have implications for basic immune regulation. The results may also help us understand the mechanism behind the development of SLE-like autoimmune diseases and B cell lymphomas. The B cell receptors (BCRs) for antigen express variable (V) regions that are enormously diverse, thus serving as markers on individual B cells. V region-derived idiotypic (Id) peptides can be displayed as pId:MHCII complexes on B cells for recognition by CD4+ T cells. It is not known if naive B cells spontaneously display pId:MHCII in vivo or if BCR ligation is required for expression, thereby enabling collaboration between Id+ B cells and Id-specific T cells. Here, using a mouse model, we show that naive B cells do not express readily detectable levels of pId:MHCII. However, BCR ligation by Ag dramatically increases physical display of pId:MHCII, leading to activation of Id-specific CD4+ T cells, extrafollicular T–B cell collaboration and some germinal center formation, and production of Id+ IgG. Besides having implications for immune regulation, the results may explain how persistent activation of self-reactive B cells induces the development of autoimmune diseases and B cell lymphomas. |
| اللغة: | English |
| تدمد: | 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f161c87049432abe13021930406bb703Test https://hdl.handle.net/10037/17157Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f161c87049432abe13021930406bb703 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00278424 |
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