التفاصيل البيبلوغرافية
العنوان:
Prognostic and biological significance of the proangiogenic factor EGFL7 in acute myeloid leukemia
المؤلفون:
Matthew H. Burke , Selen A. Yilmaz , Hatice Gulcin Ozer , Nina C. Zitzer , Thomas H. Carter , Malith Karunasiri , Michael A. Caligiuri , Adrienne M. Dorrance , Betina McNeil , Changxian Shen , Dimitrios Papaioannou , Marius Bill , Gregory K. Behbehani , Jonathan E. Kolitz , Krzysztof Mrózek , Ramiro Garzon , Damian J Steiner , Eunice S. Wang , Clara D. Bloomfield , Deedra Nicolet , Bayard L. Powell , Guido Marcucci , Christopher C. Oakes , Carlo M. Croce
بيانات النشر:
National Academy of Sciences, 2017.
سنة النشر:
2017
مصطلحات موضوعية:
0301 basic medicine , Male , Angiogenesis , Endothelial Growth Factors , Mice , 0302 clinical medicine , Risk Factors , hemic and lymphatic diseases , Angiogenic Proteins , Aged, 80 and over , Multidisciplinary , biology , Age Factors , Myeloid leukemia , Middle Aged , Prognosis , Recombinant Proteins , Up-Regulation , Leukemia , Leukemia, Myeloid, Acute , PNAS Plus , 030220 oncology & carcinogenesis , EGFL7 , Female , Antibody , Adult , EGF Family of Proteins , Disease-Free Survival , 03 medical and health sciences , Young Adult , Cell Line, Tumor , microRNA , medicine , Animals , Humans , RNA, Messenger , Autocrine signalling , Antibodies, Blocking , neoplasms , Aged , Cell Proliferation , Cell growth , Calcium-Binding Proteins , Proteins , medicine.disease , MicroRNAs , 030104 developmental biology , Case-Control Studies , Immunology , biology.protein
الوصف:
Epithelial growth factor-like 7 (EGFL7) is a protein that is secreted by endothelial cells and plays an important role in angiogenesis. Although EGFL7 is aberrantly overexpressed in solid tumors, its role in leukemia has not been evaluated. Here, we report that levels of both EGFL7 mRNA and EGFL7 protein are increased in blasts of patients with acute myeloid leukemia (AML) compared with normal bone marrow cells. High EGFL7 mRNA expression associates with lower complete remission rates, and shorter event-free and overall survival in older (age ≥60 y) and younger (age
اللغة:
English
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca0479e2e22fd9980b6ab8e7d39ae7aTest https://europepmc.org/articles/PMC5468639Test /
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....0ca0479e2e22fd9980b6ab8e7d39ae7a
قاعدة البيانات:
OpenAIRE
