Split-dose low-volume polyethylene glycol is non-inferior but less preferred compared with same-day bowel preparation for afternoon colonoscopy
| العنوان: | Split-dose low-volume polyethylene glycol is non-inferior but less preferred compared with same-day bowel preparation for afternoon colonoscopy |
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| المؤلفون: | Tajika, Masahiro, Tanaka, Tsutomu, Ishihara, Makoto, Hirayama, Yutaka, Onishi, Sachiyo, Mizuno, Nobumasa, Kuwahara, Takamichi, Okuno, Nozomi, Matsumoto, Shinpei, Toriyama, Kazuhiro, Obata, Masahiro, Kurita, Yusuke, Kondo, Shinya, Hara, Kazuo, Bhatia, Vikram, Ando, Masahiko, Niwa, Yasumasa |
| المصدر: | Nagoya Journal of Medical Science |
| بيانات النشر: | Nagoya University, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Original Paper, Cathartics, Patient Preference, Colonoscopy, split-dose, Middle Aged, Drug Administration Schedule, Polyethylene Glycols, Japan, afternoon colonoscopy, Patient Satisfaction, bowel preparation, Humans, Therapeutic Irrigation |
| الوصف: | Currently, the same-day polyethylene glycol-electrolyte lavage solution (PEG-ELS) regimen is particularly recommended for afternoon colonoscopy as an alternative to the split-dose regimen in western countries. However, in Japan, the split-dose regimen has never been used as a standard colonoscopy preparation regimen. The aim of this study was to compare the efficacy and tolerability of split-dose PEG containing ascorbic acid (ASC) with same-day single dose PEG-ASC in Japan.This was a single-blinded, non-inferiority, two-center, randomized, controlled study. In-hospital patients were randomized to the same-day regimen or the split regimen using a web-based registry system. The same-day group was instructed to take 5 mL of sodium picosulfate in the evening, and on the day of the colonoscopy, they took 1.5 L of PEG-ASC. The split group was instructed to take 1 L of PEG-ASC before the day of colonoscopy, followed by another 1 L of PEG-ASC on the day of colonoscopy. Bowel cleansing was evaluated by the Boston Bowel Preparation Scale.A total of 153 patients were randomized to either the same-day group (n=78, males 60.0%, mean age 62.7 years) or the split group (n=75, 61.3%, 61.9 years). The rates of successful bowel cleansing were 83.3% in the same-day group vs. 92.0% (83.4%–97.0%) in the split group, P=0.10). No serious adverse events occurred in the study population. However, more patients in the same-day group were willing to repeat the same preparation regimen (P |
| اللغة: | English |
| تدمد: | 2186-3326 0027-7622 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::305ac3cce526ed3b07f5ff9c98f49ee0Test http://europepmc.org/articles/PMC8648521Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........305ac3cce526ed3b07f5ff9c98f49ee0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21863326 00277622 |
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